Solid dispersion for treating peptic ulcers

A solid dispersion, peptic ulcer technology, applied in the digestive system, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc. problem, to achieve the effect of improving anti-ulcer activity and improving bioavailability

Inactive Publication Date: 2016-01-20
CHENGDU HENGLING TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The current medicines for treating the above diseases are mostly chemical me

Method used

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  • Solid dispersion for treating peptic ulcers
  • Solid dispersion for treating peptic ulcers
  • Solid dispersion for treating peptic ulcers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 pharmaceutical composition of the present invention

[0033] Atractylodes macrocephala 10g, Poria cocos 10g, red bean 10g, astragalus 7.5g, capillary 7.5g, dandelion 7.5g, bitter almond 5g, bellflower 5g, patchouli 5g, dried ginger 2.5g, ginseng 2.5g; after drying, crush to 400 mesh , after mixing uniformly, the raw material medicine powder is obtained.

[0034] Take raw drug powder: polyethylene glycol-6000=1:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

Embodiment 2

[0035] The preparation of embodiment 2 pharmaceutical composition of the present invention

[0036] 180g Atractylodes macrocephala, 220g Poria cocos, 220g red bean, 170g astragalus, 170g capillary, 170g dandelion, 120g bitter almond, 120g platycodon, 120g patchouli, 60g dried ginger, 60g ginseng; after drying, crush to 400 mesh, mix well, That is, the raw material medicine powder is obtained.

[0037] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

Embodiment 3

[0038]The preparation of embodiment 3 pharmaceutical composition of the present invention

[0039] 220g of Atractylodes macrocephala, 180g of poria cocos, 180g of red bean, 130g of astragalus, 130g of capillary, 130g of dandelion, 80g of bitter almond, 80g of bellflower, 80g of patchouli, 40g of dried ginger, 40g of ginseng; after drying, crush to 350 mesh, mix well, That is, the raw material medicine powder is obtained.

[0040] Take raw drug powder: polyethylene glycol-6000=3:1w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, pulverize to obtain Solid dispersion.

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Abstract

The invention provides a solid dispersion for treating peptic ulcers. The solid dispersion is prepared from raw medicine powder and polyethylene glycol-6000 which are matched in the proportion of 1-3:1-3 w/w. The raw medicine powder is prepared by smashing raw medicine to 300-500 meshes, wherein the raw medicine is prepared from, by weight, 7-13 parts of rhizoma atractylodis macrocephalae, 7-13 parts of poria cocos, 7-13 parts of phaseolus calcaratus, 5-10 parts of astragalus membranaceus, 5-10 parts of capillary artemisia, 5-10 parts of dandelion, 3-7 parts of semen armeniacae amarae, 3-7 parts of platycodon grandiflorum, 3-7 parts of platycodon grandiflorum, 2-3 parts of dried ginger and 2-3 parts of ginseng. The solid dispersion is prepared from raw medicine powder, the bioavailability of medicine is improved, and anti-ulcer activity is improved remarkably.

Description

technical field [0001] The invention relates to a solid dispersion for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as fullness after meals, pantothenic acid, belching, and irregular abdominal pain. Multiple verrucous, enl...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/14A61P1/04
Inventor 李智叶英安静
Owner CHENGDU HENGLING TECH CO LTD
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