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Interpenetrating network hydrogel based on alginic acid and oligopeptide and preparation method thereof

A technology of interpenetrating network, alginic acid

Inactive Publication Date: 2016-01-20
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no interpenetrating network gel based on alginic acid and short peptide has been reported, and the process conditions and functional properties still need to be further developed.

Method used

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  • Interpenetrating network hydrogel based on alginic acid and oligopeptide and preparation method thereof
  • Interpenetrating network hydrogel based on alginic acid and oligopeptide and preparation method thereof
  • Interpenetrating network hydrogel based on alginic acid and oligopeptide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Interpenetrating network hydrogel based on alginic acid / Fmoc-Y composition

[0021] First, preheat sodium alginate aqueous solution (15mg / mL) to 60°C, then add 15μL of Fmoc-Y DMSO solution (100mg / mL), heat together to obtain a uniform and transparent solution, and then add 100μLCaCl 2 Solution (0.2mol / L), shake rapidly to make initial gelation, then cool to room temperature and stand for 24h to prepare alginic acid / Fmoc-Y short peptide interpenetrating network hydrogel.

Embodiment 2

[0023] Encapsulation of rhodamine B by interpenetrating network hydrogel based on alginic acid / Fmoc-Y composition

[0024] First, preheat the mixed solution of sodium alginate (15 mg / mL) and rhodamine B (1 mg / mL) to 60 °C, then add 15 μL of Fmoc-Y DMSO solution (100 mg / mL), and heat together to obtain a uniform and transparent solution. Then add 100μLCaCl 2 Solution (0.2mol / L), shake rapidly to make initial gelation, then cool to room temperature and let it stand for 24h to prepare rhodamine B-embedded alginic acid / Fmoc-Y short peptide interpenetrating network hydrogel.

Embodiment 3

[0026] Embedding of 5-aminosalicylic acid in interpenetrating network hydrogel based on alginic acid / Fmoc-Y composition

[0027] First, preheat the mixed solution of sodium alginate (15mg / mL) and 5-aminosalicylic acid (1mg / mL) to 60°C, then add 15μL of Fmoc-Y DMSO solution (100mg / mL) and heat together to obtain a uniform and transparent solution, and then add 100 μLCaCl 2 solution (0.2mol / L), shake rapidly to make it initially gel, then cool to room temperature and stand for 24h to prepare alginic acid / Fmoc-Y short peptide interpenetrating network hydrogel embedded with 5-aminosalicylic acid .

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Abstract

The invention discloses an interpenetrating network hydrogel based on alginic acid and oligopeptide and a preparation method thereof. The interpenetrating network hydrogel is characterized in that two materials with different gelatinization mechanism properties are combined. A preparation process comprises the following two steps: (1) by utilizing temperature responsive properties of an oligopeptide gel behavior, mixing sodium alginate and the oligopeptide at a temperature higher than a critical gel temperature, and firstly, obtaining first network polysaccharide gel by adding multivalent metal ions; (2) cooling the first network polysaccharide gel to be lower than the critical gel temperature, wherein the oligopeptide is self-assembled between first networks through pi-pi accumulation effect and a hydrogen bond, and is further gelatinized to obtain a second network. The interpenetrating network hydrogel disclosed by the invention has a more dense network structure and higher mechanical strength and the content is not easy to leak; a multi-responsiveness function unit is convenient to design and the releasing of medicines is controlled by using different physical stimulations.

Description

technical field [0001] The invention relates to the field of polymer materials. Specifically relates to an interpenetrating network hydrogel based on alginic acid and short peptides and a preparation method thereof. Background technique [0002] As a material with high water absorption and high water retention, hydrogel is widely used in many fields such as daily chemical industry, agriculture, medicine, food and so on. However, there are still some problems in the embedding technology of hydrogel in the above fields. For example, when embedding hydrophilic small molecule substances, due to the small molecular weight and good water solubility, there are shortcomings such as low embedding efficiency and difficult release control. . Interpenetrating network (interpenetrating network, IPN) hydrogel has a denser network structure, its inclusions are not easy to leak, and it is convenient to design multiple responsive functional units to realize the control of drug release by u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/04C08J3/075C08J3/24
Inventor 李娟陈嘉慧刘又年孙晓毅
Owner CENT SOUTH UNIV
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