Oxymatrine solid dispersion-supported floating sustained-release pellet for stomach and preparation method of oxymatrine solid dispersion-supported floating sustained-release pellet

Abstract

The invention relates to an oxymatrine solid dispersion-supported floating sustained-release pellet for the stomach and a preparation method of the oxymatrine solid dispersion-supported floating sustained-release pellet. The pellet is prepared from the following three parts: (1) an active component oxymatrine solid dispersion, (2) a sodium alginate matrix layer containing a bubble cavity, and (3) a chitosan sustained-release coating material layer, which can persistently float in gastric juice and slowly releases a medicine (oxymatrine). The preparation is applied to a sodium alginate-chitosan multi-unit gastric floating drug delivery system; a solid dispersion technology is combined; the oxymatrine pellet which is densely crosslinked inside, but has a bubble structure is prepared by crosslinking reaction; and the oxymatrine solid dispersion-supported floating sustained-release pellet has the characteristics of high bioavailability and high curative effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oxymatrine gastric floating drug delivery system and a preparation method thereof, in particular to a gastric floating slow-release pellet loaded with a solid dispersion of oxymatrine and a preparation method thereof. Background technique [0002] Oxymatrine is an alkaloid extracted from Ningxia's characteristic bulk medicinal herb Sophora sophora. As a commonly used clinical drug, it has good curative effects in the treatment of hepatitis B, hepatitis C, and leukopenia. Common dosage forms of oxymatrine include ordinary capsules, injections, etc., and there are reports in the literature that they are designed as oxymatrine slow-release preparations and osmotic pump preparations. and rectum) will be metabolized into matrine which is different from its pharmacological activity and therapeutic effect. Ordinary sustained-release preparations cannot achieve the sustained-...

AI Technical Summary

Problems solved by technology

Common dosage forms of oxymatrine include ordinary capsules, injections, etc., and there are reports in the literature that they are designed as oxymatrine slow-release preparations and osmotic pump preparations. and rectum) will be metabolized into matrine which is different from its pharmacological activity and therapeutic effect

Ordinary sustained-release preparations cannot achieve the sustained-release and long-acting effects of oxymatrine in the body

Therefore, oral administration of oxymatrine preparations will lead to a decrease in the bioavailability of oxymatrine

How to solve the problem that oxymatrine is easily degraded in the back of the intestinal tract, resulting in a decrease in bioavailability, is a difficult problem that pharmaceutical workers have been working on

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