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Application and method for Shanhaidan Yitongshu injection percutaneous drug delivery transdermal absorption

A technology of Shanhaidan Yitongshu and Yitongshu injection, which is applied in the field of pharmaceutical preparations, can solve the problems of reducing patient treatment compliance, pain at the injection site, infection, broken needle and other treatment risks, so as to reduce medical risks, Improving treatment compliance and prolonging the effect of treatment

Inactive Publication Date: 2016-01-27
陕西医药控股集团山海丹药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yitongshu injection adopts intramuscular injection or acupoint injection, and there are treatment risks such as pain at the injection site, infection, broken needle, etc., and reduces the patient's treatment compliance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] In the embodiment of the present invention, the application and method of transdermal absorption of Shanhaidan Yitongshu injection through skin administration, adding a percutaneous penetration enhancer with a mass fraction of 0.2% to Yitongshu injection, and adjusting it with a pH regulator When the pH value reaches 6.3, the obtained solution is made into a transdermal drug delivery preparation, which enters the human body circulation through capillaries to produce drug effects.

Embodiment 2

[0011] In the embodiment of the present invention, the application and method of transdermal absorption of Shanhaidan Yitongshu injection through skin administration, adding a percutaneous penetration enhancer with a mass fraction of 0.25% to Yitongshu injection, and adjusting the pH value with a pH regulator When the pH value reaches 6.6, the obtained solution is made into a transdermal drug delivery preparation, which enters the human body circulation through capillaries to produce drug effects.

Embodiment 3

[0013] In the embodiment of the present invention, the application and method of transdermal absorption of Shanhaidan Yitongshu injection through skin administration, adding a percutaneous penetration enhancer with a mass fraction of 0.3% to Yitongshu injection, and adjusting it with a pH regulator When the pH value reaches 6.8, the obtained solution is made into a transdermal drug delivery preparation, which enters the human body circulation through capillaries to produce drug effects.

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PUM

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Abstract

The invention discloses an application and method for Shanhaidan Yitongshu injection percutaneous drug delivery transdermal absorption. A percutaneous penetration promoter with a mass fraction of 0.2-0.3% is added in Yitongshu injection, the pH value is adjusted to 6.3-6.8 by utilization of a pH adjusting agent,Z the obtained solution is prepared into a percutaneous drug delivery preparation, the preparation goes into human circulation through a capillary vessel and generates pharmacological effects, and the preparation is used for dispelling wind and cold, invigorating blood circulation and relieving pain. The Yitongshu injection percutaneous drug delivery mode is better than an intramuscular injection mode at aspects of drug absorption, drug effects and safety, thus the new treatment mode meets clinic safe, effective, convenient and economical treatment principles, and active social benefits are generated for lowering medical risks and raising treatment compliance.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to the application and method of Shanhaidan Yitongshu injection through skin administration and transdermal absorption. Background technique [0002] Yitongshu injection can significantly prolong the pain threshold time of mice induced by hot plate method, reduce the number of writhing reactions in mice induced by acetic acid, and relieve the pain symptoms of knee arthritis in rats induced by sodium urate. Expelling wind and cold to overcome dampness, promoting blood circulation and dispelling blood stasis to relieve pain. It is used for headaches caused by various reasons, toothache, neuralgia, rheumatism and fibromyalgia, pain caused by bone and joint, gastrointestinal, gallbladder, kidney diseases, cancer, etc. According to TCM syndrome differentiation and medication, it has a good effect especially on pain syndromes caused by cold pathogens and blood stasis....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K45/06A61P29/00
Inventor 翁晓伟李小兵
Owner 陕西医药控股集团山海丹药业股份有限公司
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