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Controllable-phase strontium-doped calcium phosphate powder and preparing method thereof

A technology for strontium calcium phosphate and powder, which is applied in the field of controllable phase-doped strontium calcium phosphate powder and its preparation, can solve the problems of difficult control of two-phase components and proportions, appearance of impurity phases, and harsh sintering temperature control, and achieves Improves osteoinductive properties and bioactivity

Active Publication Date: 2016-02-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still relatively few studies on the effect of Sr doping on the phase composition of HA and β-TCP in BCP ceramics and the phase regulation process
The existing BCP ceramics obtained according to the stoichiometric ratio method or by controlling the degree of calcium deficiency of the precursor and the sintering temperature are difficult to control the two-phase composition and ratio, and even impurity phases appear, and the sintering temperature control is also relatively strict

Method used

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  • Controllable-phase strontium-doped calcium phosphate powder and preparing method thereof
  • Controllable-phase strontium-doped calcium phosphate powder and preparing method thereof
  • Controllable-phase strontium-doped calcium phosphate powder and preparing method thereof

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Effect test

Embodiment 1

[0027] (1) Prepare 0.5mol / LCa(NO 3 ) 2 4H 2 O solution, 0.5mol / LSr(NO 3 ) 2 solution and 0.25mol / L (NH 4 ) 3 PO 4 ·3H 2 O solution, as calcium source, strontium source and phosphorus source. According to the molar ratio of (Ca+Sr) / P=1.67, a certain amount of Ca(NO 3 ) 2 4H 2 O and Sr(NO 3 ) 2 After the solution is mixed, use concentrated ammonia water to adjust the pH of the solution to be greater than 11. After vigorously stirring at 30°C, add polyethylene glycol (molecular weight: 6000) dispersant, and stir for 30 minutes to obtain a mixed solution containing calcium source and strontium source.

[0028] (2) At the same time adjust with concentrated ammonia water (NH 4 ) 3 PO 4 ·3H 2 The pH value of the O solution is greater than 10 to obtain a solution containing a phosphorus source; after controlling the dropping rate to 4mL / min with a peristaltic pump, slowly drop the solution containing a phosphorus source into the mixed solution containing a calcium sour...

Embodiment 2

[0036] (1) Prepare 0.5mol / LCa(NO 3 ) 2 4H 2 O solution, 0.5mol / LSr(NO 3 ) 2 solution and 0.25mol / L (NH 4 ) 3 PO 4 ·3H 2 O solution, as calcium source, strontium source and phosphorus source. According to the molar ratio of (Ca+Sr) / P=1.67, a certain amount of Ca(NO 3 ) 2 4H 2 O and Sr(NO 3 ) 2 After the solution is mixed, use concentrated ammonia water to adjust the pH of the solution to be greater than 11. After vigorously stirring at 30°C, add polyethylene glycol (molecular weight: 6000) dispersant, and stir for 30 minutes to obtain a mixed solution containing calcium source and strontium source.

[0037] (2) At the same time adjust with concentrated ammonia water (NH 4 ) 3 PO 4 ·3H 2 The pH value of the O solution is greater than 10 to obtain a solution containing a phosphorus source; after controlling the dropping rate to 4mL / min with a peristaltic pump, slowly drop the solution containing a phosphorus source into the mixed solution containing a calcium sour...

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Abstract

The invention belongs to the technical field of biomedical materials and discloses controllable-phase strontium-doped calcium phosphate powder and a preparing method thereof. The preparing method comprises the steps of adding a (NH4)3PO4.3H2O solution to a Ca(NO3)2.4H2O and (NH4)3PO4.3H2O mixing solution dropwise for reaction according to the molar ratio of (Ca+Sr) / P=1.67, conducting centrifugal washing and drying on the reaction product, and conducting grinding to obtain strontium-doped calcium phosphate precursor powder; conducting heat preservation sintering on the strontium-doped calcium phosphate precursor powder at 900-1200 DEG C, and obtaining the controllable-phase strontium-doped calcium phosphate powder after cooling. Strontium-doped calcium phosphate biphase powder with different HA and beta-TCP proportions can be prepared in a controllable mode by adjusting the strontium doping amount, and higher biological activity and broader application prospects are realized compared with traditional calcium phosphate powder.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a controllable substance phase-doped strontium calcium phosphate powder and a preparation method thereof. Background technique [0002] Calcium phosphate biphasic ceramics (BCP) have the high strength, high bioactivity, stability of HA (hydroxyapatite) and the absorption and degradation characteristics of β-TCP. They are an important class of bone repair materials and have been widely studied and applied. At present, the BCP preparation methods mainly include: ①preparation of calcium-deficient apatite by wet method, and then sintering; ②solid-state reaction method; ③direct mechanical mixing of pure HA and pure β-TCP in a certain proportion. The mechanical mixing method is not easy to obtain nano-sized HA and β-TCP powder, and the uniformity of the dual-phase powder is not good enough; the solid-state reaction method has disadvantages such as low efficienc...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/12A61L27/54
CPCA61L27/047A61L27/12A61L27/54
Inventor 邓春林何丽泳
Owner SOUTH CHINA UNIV OF TECH
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