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Method for synthesizing N-fatty acyl group amino acid

A fatty acyl amino acid, fatty acid ester technology, applied in chemical instruments and methods, preparation of organic compounds, preparation of carboxylic acid nitriles, etc., can solve the problems of product purity that is difficult to meet industrial needs, complicated operation, etc.

Inactive Publication Date: 2016-02-24
上海利盛生化有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the technology is complicated to operate, and a large amount of acid produced in the acid chloride method needs to be treated, and the purity of the obtained product is also difficult to meet industrial needs.

Method used

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  • Method for synthesizing N-fatty acyl group amino acid
  • Method for synthesizing N-fatty acyl group amino acid
  • Method for synthesizing N-fatty acyl group amino acid

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0019] Example group 1

[0020] This embodiment is implemented in the following ways:

[0021] Step 1) Add 429g (2mol) methyl laurate into a four-necked flask, start stirring, and further add 140g (2mol) aminopropionitrile and 28% sodium methoxide / methanol solution.

[0022] Step 2) Using nitrogen to replace air, the reaction temperature is very slow below 70°C, and the color of the material is darker than 120°C, so the reaction temperature is controlled between 70 and 120°C.

[0023] The effects of catalyst dosage and reaction temperature on the experimental results were obtained through experimental comparison, as shown in Table 1. The optimum reaction temperature was 90°C, and the catalyst addition amount was 5.0% (molar ratio).

[0024] Table 1

[0025]

[0026] Example group 2

[0027] In the present embodiment, concentrated sulfuric acid is added to the reaction solution of the above-mentioned embodiment 3, and the reaction solution is cooled to 0° C. after being ...

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Abstract

The invention discloses a method for synthesizing N-fatty acyl group amino acid. With fatty acid ester and amino-nitrile adopted as the raw materials, and with sodium methylate or sodium ethoxide adopted as the catalyst, the method comprises the following steps: heating under nitrogen protection; adjusting the pH value to be acid; after refrigeration, filtering the reaction liquid; carrying out reduced pressure distillation on the obtained solid; collecting the cut fraction, and placing in alkali liquor for hydrolysis, so as to obtain N-fatty acyl group amino acid salt; or collecting the cut fraction, and carrying out acidification to prepare N-fatty acyl group amino acid. According to the method, amino-nitrile and fatty acid ester are adopted as the raw materials to prepare high purity N-fatty acyl group amino acid, the raw materials are cheap, the equipment is simple, and waste water generated during the production process is less.

Description

technical field [0001] The invention relates to a technology in the field of daily necessities, in particular to a method for synthesizing N-fatty acyl amino acids. Background technique [0002] N-fatty acyl amino acids and their salts are widely used as an excellent surfactant with bacteriostatic effect and low irritation. The currently widely used method for synthesizing N-fatty acyl amino acids in industry is the Schotten-Baumann reaction. First, fatty acid chlorides are prepared by reacting fatty acids with phosphorus trichloride, and then the amino acid salts and fatty acid chlorides are reacted in an alkaline environment. The production of a large amount of acid gas and acid water in the reaction process pollutes the environment, and the treatment cost of by-products greatly increases the product cost. [0003] After searching the prior art, it is found that Chinese Patent Document No. CN103408449A, published (announcement) date 2013.11.27, discloses a preparation met...

Claims

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Application Information

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IPC IPC(8): C07C233/47C07C231/12
CPCC07C231/12C07C253/30
Inventor 李洪楚艳冰李新华
Owner 上海利盛生化有限公司
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