23 results about "Amino nitriles" patented technology

The invention provides a catalyst for one-step preparation of diamine from lactam and a preparation method and application of the catalyst. A catalyst carrier is sequentially subjected to sensitization treatment operation in the step S1, activation treatment operation in the step S2 so as to enable the catalyst carrier to load active metal, complexing treatment operation in the step S3, reduction treatment operation in the step S4 and acid treatment operation in the step S5; the catalyst can be coupled with an ammoniation reaction for preparing diamine from lactam and an aminonitrile hydrogenation reaction, so that the diamine is produced through one-step reaction of lactam, and the production process is greatly simplified.

The invention relates to a method for converting an N-formyl-protected amine into the corresponding deprotected amine, characterized in that the N-formyl-protected amine is deprotected by decomposing the formyl into carbon dioxide and hydrogen in the presence of water and a dehydrogenation catalyst and at a temperature in the range of 10 DEG C to 300 DEG C. The process can be used to effectively deprotect an N-formyl-protected amino alcohol intermediate in a process for preparing an amino alcohol by reductive hydrolysis of a nitrile functional group starting from an N-formyl-protected amino nitrile followed by deprotection of the N-formyl-protected amino alcohol intermediate.

The invention relates to the technical field of ink, and particularly discloses ink-jet ink with good weather resistance and a preparation method of the ink-jet ink. The ink-jet ink with good weather resistance comprises the following raw material components: 3.2-4.0 wt% of a modified dye; 2.8 to 3.4 wt% of waterproof nano particles; 8.0 to 10.0 wt% of a water-based epoxy resin emulsion; 4.5 to 5.0 wt% of a humectant; 2.5-3.0 wt% of a color fixing auxiliary agent; 2.5 to 3.0 wt% of a pH conditioning agent; 2.2 to 2.8 wt% of a thickening agent; the solvent is the balance; the preparation method of the modified dye comprises the following steps: blending the dye and an aromatic aminonitrile modifier, reacting, separating out solid, and post-treating, the preparation method comprises the following steps: blending the raw materials, and uniformly stirring. The ink-jet ink has good weather resistance and color fixing capacity, the light fading rate is smaller than or equal to 22%, the washing residual rate is larger than 90%, and the color fixing rate is not lower than 85%.

The present invention belongs to the field of sodium ion batteries, and discloses a sodium ion battery electrolyte, including a sodium salt and a solvent, and also including an additive, wherein the additive has the following general formula I; wherein at least two of the three substituents R are amino groups and nitrile groups. Since the thiazolyl group and the amino group have weak alkalinity, they have the effect of reducing the HF content under high voltage, reducing the precipitation of metal ions in the positive electrode, and enhancing the stability of the interface film between the positive electrode and the electrolyte. The nitrile group can complex the ions of the positive electrode of the sodium ion battery to form an interface film on the surface of the positive electrode. The interface film can effectively inhibit the decomposition of the electrolyte and reduce the precipitation of metal ions, thereby improving the cycle performance of the high voltage system. In addition, the present invention also discloses a sodium ion battery.

The present invention belongs to the technical field of preparation of metal hydrides, and specifically relates to a palladium-based hydride and a preparation method and application thereof. The present invention generates hydrogen through a cross-coupling reaction between a hydrogenating agent, iminonitrile, and a phenyl alcohol organic solvent. This combined hydrogenation mechanism not only ensures a high exposure density of active metal palladium sites, but also a high hydrogen content can effectively induce crystal expansion of Pd crystals, and enhance the electronic interaction between neighboring atoms, optimize the crystal structure and electronic configuration of the palladium-based hydride catalyst, and is conducive to improving the activity and stability of the palladium-based hydride catalyst, greatly improving its specific activity, effectively reducing the use of metal palladium, and effectively reducing the use cost. It exhibits relatively excellent electrocatalytic activity for EOR under alkaline conditions and has considerable energy application potential.

Positron emission tomography and magnetic resonance imaging are among the most widely used modalities, requiring isotopic labeling of bioactive molecules to generate the desired imaging probes. This method was applied to a wide range of aliphatic carboxylic acids, including complex and functionalized drug molecules, amino acids and short peptides. For non-stabilized radicals derived from benzylic and non-benzylic carboxylic acids, a copper co-catalyst was introduced to obtain the labeled nitriles, whereas metal-free conditions were applied to nitrogen-stabilized radical derived from a-amino acids and peptides to form the radiolabeled a-amino nitriles. These radiolabeled nitriles were then easily converted back to radiolabeled carboxylic acids.

The invention provides a synthesis method of an alpha-aminonitrile compound, and relates to the technical field of organic synthesis. The synthesis method provided by the invention comprises the following step: in an acidic solvent environment, under the action of a photocatalyst and a reducing agent, reacting a fatty amine compound I, a fatty aldehyde / ketone compound II and a cyano donor under illumination to generate the alpha-aminonitrile compound III. The raw materials are easy to obtain, the reaction conditions are mild, the compatibility of functional groups is good, the application range of substrates is wide, and the pollution to the environment is small.

The application relates to an industrialized preparation method and application of high-purity alpha-amino nitrile. The application belongs to the technical field of fine chemical synthesis. The purpose of the application is to solve the technical problems of low yield and purity, high cost and unsuitability for industrialized production of the existing alpha-amino nitrile synthesis method. The method of the application is as follows: taking imine as a substrate, alpha-amino nitrile is synthesized by reacting with acetone cyanohydrin under the action of an ionic liquid. The method of the application synthesizes a nucleophilic addition cyanyl product of a carbon-nitrogen double bond in one step at room temperature. By selecting the ionic liquid and reasonably controlling the proportioning of various substances, the reaction process is greatly accelerated, the high-efficiency synthesis of alpha-amino nitrile is realized, the purity of alpha-amino nitrile is remarkably improved, the substrate adaptability is good, and the method can be widely applied to the synthesis in the fields of medicines and the like in the industry and the academia.

The invention discloses an electrolyte additive for a lithium or sodium ion battery and an application thereof, belonging to the technical field of lithium batteries; the electrolyte additive comprises g-C3N4 and a film-forming additive, and the g-C3N4 and the film-forming additive are coupled to form a negative electrode solid electrolyte interface film through intermolecular hydrogen bonding; the film-forming additive comprises one or more organic substances containing a carbonyl bond, an ether bond, a hydroxyl group, a carboxyl group, an amino group, a nitrile group, a thiol group, a sulfonic acid group, a hydrocarbon oxygen carbonyl group, a haloformyl group, a carbamoyl group, a formyl group, an amide group, and a halogen; in terms of mass fractions, the content of g-C3N4 accounts for 0.001%-5% of the total electrolyte mass, and the content of the film-forming additive accounts for 0.01%-30% of the total electrolyte mass. The present invention uses g-C3N4 with strong nucleophilic ability and a film-forming additive for coupling. During the electrochemical reaction, a negative electrode solid electrolyte interface film rich in nitrogen and with good conductivity is formed. The film can inhibit the generation of lithium / sodium dendrites, achieve uniform deposition of lithium / sodium, and improve the rate and cycle performance of the battery.

The present application relates to a cis-para-substituted cyclohexylaminonitrile salt represented by formula (I), a preparation method therefor and use thereof as an intermediate for preparing a pesticide, and a method for preparing the pesticide by using same as an intermediate. In the formula, R is C1-10 alkyl or C1-10alkyloxy, C2-10 alkenyl or C2-10 alkenyloxy, C2-10 alkynyl or C2-10 alkynyloxy, C3-10 cycloalkyl or C3-10 cycloalkyloxy, C3-10 heterocycloalkyl or C3-10 heterocycloalkyloxy containing 1-2 heteroatoms selected from O and N.

Positron emission tomography and magnetic resonance imaging are among the most widely used modalities, requiring isotopic labeling of bioactive molecules to generate the desired imaging probes. This method was applied to a wide range of aliphatic carboxylic acids, including complex and functionalized drug molecules, amino acids and short peptides. For non-stabilized radicals derived from benzylic and non-benzylic carboxylic acids, a copper co-catalyst was introduced to obtain the labeled nitriles, whereas metal-free conditions were applied to nitrogen-stabilized radical derived from a-amino acids and peptides to form the radiolabeled a-amino nitriles. These radiolabeled nitriles were then easily converted back to radiolabeled carboxylic acids.

The invention provides a novel preparation method of a trifluoromethylthio-oxime carbonate bifunctional reagent. The trifluoromethylthio-oxime carbonate bifunctional reagent is used for preparing a trifluoromethylthio-oxime carbonate bifunctional reagent; the bifunctional reagent and olefin are utilized for the first time, and three different strategies are developed to synthesize the trifluoromethylthio-containing amine compound: direct o-trifluoromethylthio amination of olefin, 1, 4-trifluoromethylthio amination of olefin formed by series connection of two different electrical olefins, and 1, 4-trifluoromethylthio amination of olefin combined with migration reaction of free radical 1, 4-cyano, so that the trifluoromethylthio-containing amine compound is synthesized. And carrying out 2, 3, 5-trifluoromethylthiolation and amination. In addition, a halogen atom extraction strategy is further utilized, and trifluoromethylthiolation halogenation of olefin is achieved. The invention also provides amino-acid ester and amino-nitrile compounds containing SCF3 structural fragments, which cannot be obtained previously and have structural diversity, and the compounds are expected to provide more candidate molecules for developing trifluoromethylthio-containing drugs.

This invention provides a method for synthesizing milobalin benzylsulfonic acid, comprising the following steps: a chiral enone undergoes a condensation reaction with cyanoacetate in the presence of ammonium acetate to obtain an unsaturated cyano ester; next, the unsaturated cyano ester undergoes a condensation reaction with nitromethane to obtain a nitro ester; the nitro ester is then deesterified at high temperature to obtain a chiral nitro nitrile, which is then reduced to a chiral amino nitrile; subsequently, the chiral amino nitrile is hydrolyzed to obtain the free base of milobalin; finally, the free base of milobalin is salted with benzylsulfonic acid to obtain milobalin benzylsulfonic acid. This invention stereospecifically constructs a chiral cyclobutane quaternary carbon center to obtain a chiral nitro ester with a single stereoconfiguration, avoiding the chiral isomer waste generated by chiral isomer resolution, eliminating the need for chiral column separation or chiral resolution, significantly reducing production costs, and simultaneously avoiding the environmental pollution caused by residual heavy metal titanium in the product and solid waste heavy metal titanium.

The present invention discloses a method for photocatalytic synthesis of tetracyclic quinazolinones under metal-free conditions. The synthesis process of this method is as follows: In a glass reaction vessel, different types of substrates N-acyl-N-(2-bromobenzyl)amino nitriles are added in proportion, with N,N-diisopropylethylamine as an additive and 2,4,5,6-tetrakis(diphenylamino)isophthalonitrile (4-DPAIPN) as a catalyst. Using acetonitrile as a solvent, under a nitrogen atmosphere, the reaction is irradiated with two blue LEDs (450 - 460 nm) at 68 oC for 8 hours. After the crude product is separated and purified by column chromatography, tetracyclic quinazolinone derivatives are obtained. The present invention uses cheap and readily available 2-bromobenzylamine as a raw material, avoiding the use of precious metal catalysts, toxic reagents, and expensive raw materials. In addition, this reaction is simple to operate, has mild conditions, and excellent separation yields.

The invention relates to the technical field of sulfydryl nitrile feeding, and discloses sulfydryl nitrile solid feeding equipment which comprises a feeding hopper, supporting racks are symmetrically arranged on the two sides of the feeding hopper, and a conveying mechanism is jointly arranged on the sides, close to each other, of the two supporting racks. The conveying mechanism is used for conveying bagged sulfanilonitrile materials to the interior of the feeding hopper; according to the sulfydryl nitrile solid feeding equipment, automatic transmission of bagged sulfydryl nitrile materials is achieved through the arrangement of the conveying mechanism, packaging bags are scratched through the bag breaking conveying mechanism, the sulfydryl nitrile materials are discharged from the bottom, solid powder flying dust is reduced, meanwhile, materials in the packaging bags are promoted to be thoroughly discharged through the discharging promoting mechanism, and the discharging efficiency is improved. And then the materials are filtered and guided in through the guiding and filtering mechanism, the hardened materials are crushed through the crushing mechanism and then fed, and therefore the multiple functions of automatic feeding, dust raising reducing, filtering and crushing are achieved.

The invention belongs to the technical field of fine chemical engineering, and particularly relates to a method for synthesizing 1, 1, 3, 3-tetramethylguanidine, which comprises the following steps: step 1, adding dimethylamine into a reaction flask, starting stirring, then controlling the temperature at 20-50 DEG C, introducing chlorine gas into the reaction liquid while adding hydrocyanic acid for 1-4 hours, reacting to generate dimethylamino nitrile and dimethylamine hydrochloride, and then adding the dimethylamine hydrochloride into the reaction flask to obtain dimethylamine hydrochloride; the method comprises the following steps: 1, preparing a reaction solution, 2, heating the reaction solution to carry out a condensation reaction so as to generate tetramethylguanidine hydrochloride, and 3, adding liquid caustic soda into the reaction solution to carry out alkalization so as to generate tetramethylguanidine, and sequentially carrying out dimethylamine recovery, solvent extraction, solvent concentration and rectification on the reaction solution so as to finally obtain tetramethylguanidine. The method is simple in technological process, mild in reaction condition, free of high-temperature and high-pressure operation, low in production risk and beneficial to large-scale production.

This invention belongs to the field of synthetic technology of β-aminonitriles and their derivatives, specifically relating to a method for synthesizing nitrogen-alkylated unsaturated polycyclic β-aminonitriles. Under inert gas protection, this invention uses inexpensive industrial-grade nitrile compounds and primary alcohols as raw materials, adding a base and an organorruthenium catalyst, and employs a one-pot method to achieve the ring-cloning reaction of the nitrile compounds, the dehydrogenation coupling reaction of the primary alcohol, and the reduction reaction of the carbon-nitrogen double bond to synthesize nitrogen-alkylated unsaturated polycyclic (five-membered ring, six-membered ring) β-aminonitriles. The reaction system is simple, the operation is convenient, the reaction conditions are mild, and the reaction substrates have good applicability. The obtained nitrogen-alkylated unsaturated polycyclic β-aminonitriles exhibit high yield and high chemoselectivity. Furthermore, this invention overcomes the shortcomings of limited substrate range, expensive raw materials and reagents, complex reaction systems, and lengthy synthetic steps, resulting in high economic efficiency, environmental friendliness, and simple post-reaction processing.

The application provides an electrolyte and a battery. The electrolyte comprises an electrolyte salt, a solvent, and at least one additive A as shown in formula (I): wherein at least one pair of R1 and R4 and R2 and R3 contains an amino group, and the other pair contains at least one of an amino group, a nitrile group and an isocyanate group. The electrolyte can make the battery have good cycle performance and storage performance.

The invention relates to an industrial preparation method and application of high-purity alpha-aminonitrile. The invention belongs to the technical field of fine chemical synthesis. The invention aims to solve the technical problems that the existing alpha-aminonitrile synthesis method is low in yield and purity, high in cost and not suitable for industrial production. According to the method disclosed by the invention, imine is taken as a substrate and reacts with acetone cyanohydrin under the action of ionic liquid to synthesize alpha-aminonitrile. According to the method disclosed by the invention, the nucleophilic addition cyanidation product of carbon-nitrogen double bonds is synthesized in one step at room temperature. The method has the advantages that the reaction process is greatly accelerated by selecting the ionic liquid and synergistically reasonably controlling the ratio of the substances, the efficient synthesis of the alpha-aminonitrile is realized, the purity of the alpha-aminonitrile is obviously improved, the substrate adaptability is good, and the method can be widely applied to the synthesis of the fields such as medicines in the industrial circle and the academic circle.

The application belongs to the technical field of organic synthesis, and particularly relates to an amino nitrile compound with a remote chiral center and a preparation method and application thereof. The nickel-hydrogen catalytic asymmetric hydrogenation reaction provided by the application is realized through non-covalent pi-pi interaction between a cyano group in an olefin substrate and a chiral bisoxazoline ligand. The method not only realizes efficient and high-selectivity conversion of various olefin substrates and amine electrophilic reagents, but also is compatible with secondary alkyl amine electrophilic reagents, amide electrophilic reagents and benzisoxazole electrophilic reagents, thereby providing a reliable way for synthesizing chiral amino nitrile compounds (formula I) with a remote (beta-, gamma- and delta-) stereogenic center and various structures.

The invention provides an electrolyte and a battery. The electrolyte comprises an electrolyte salt, a solvent and at least one additive A as shown in a formula (I): # imgabs0 #, at least one pair of R1 and R4 and at least one pair of R2 and R3 contains amino groups, and the other pair of R1 and R4 and R2 and R3 contains at least one of amino groups, nitrile groups and isocyanate groups. The electrolyte enables the battery to have good cycle performance and storage performance.

The invention provides an (S)-aminonitrile hydrochloride compound and a preparation method thereof, and belongs to the technical field of medicine synthesis and preparation, the preparation method comprises the following steps: under inert conditions, S1, mixing a compound 1, 4-dimethylaminopyridine, pyridine and a reaction solvent, and adding paratoluensulfonyl chloride for reaction to obtain a compound 2; s2, mixing the compound 2 with a reaction solvent, and adding sodium cyanide for reaction to obtain a compound 3; s3, putting a magnesium rod into a reaction bottle, and dropwise adding a methanol solution of the compound 3 at room temperature for reaction to obtain a compound 4; and S4, mixing the compound 4 with an HCl organic solvent for reaction to obtain a target compound 5, namely the (S)-aminonitrile hydrochloride compound. The (S)-aminonitrile hydrochloride compound and the preparation method thereof provided by the invention have the advantages of high conversion rate, high yield, short steps, simple operation and low cost, and are suitable for industrial production.