85 results about "Amino nitriles" patented technology

A process for preparing a polyamide by reacting at least one aminonitrile with water comprises:(1) reacting at least one aminonitrile with water at a temperature from 100 to 360° C. and a pressure from 0.1 to 35x106 Pa to obtain a reaction mixture,(2) further reacting the reaction mixture at a temperature from 150 to 400° C. and a pressure which is lower than the pressure in step 1, the temperature and the pressure being selected so as to obtain a first gas phase and a first liquid or a first solid phase or a mixture of first solid and first liquid phase, and the first gas phase is separated from the first liquid or the first solid phase or from the mixture of first liquid and first solid phase, and(3) admixing the first liquid or the first solid phase or the mixture of first liquid and first solid phase with a gaseous or liquid phase comprising water at a temperature from 150 to 360° C. and a pressure from 0.1 to 30x106 Pa to obtain a product mixture.

The invention provides a novel method for activating and regenerating acticarbon and a novel process for decoloring. The invention utilizes the functions of oxidation and dehydration of sulphuric acid and carries out polymerization on organic pigment and modification on surface functional groups of the acticarbon to restore the adsorptive capacity of the acticarbon. The invention is in particular suitable for the field of preparation of amino acid through hydrolysis of amino nitrile, solves the difficult problems of difficult treatment of waste acticarbon, serious environmental pollution in the transferring and recycling process, high energy consumption and material consumption and poor applying effect, can achieve online recycling and use, can greatly reduce the use amount of the acticarbon and reclaim products entrained in the acticarbon; and the provided method is simple, is wide in application surface, clean and environment-friendly and has good environmental protection benefit and economic benefit.

The invention discloses a synthesis process for preparing (S)-2-aminobutyramide by enzymatic method. The current preparation method has problems such as high cost, low yield, and large environmental hazards. The technical scheme adopted in the invention is: using 2-aminobutyronitrile as a starting material to prepare (S)-2-aminobutyramide in one step in a buffer solution system through enzyme catalysis. In the present invention, water is used as a solvent in the main process, without using a large amount of organic solvents harmful to the environment, the whole process cost is low, and it is beneficial to large-scale industrial preparation.

The invention provides a method for synthesizing quinazoline-4-(3H)-ketone and belongs to the field of organic synthesis. A reaction formula is expressed in a figure, wherein a reacting alkali is diethylamine, triethylamine, ammonium acetate, sodium (potassium) hydroxide and sodium (potassium) alkoxide; a reacting solvent is 1,4-dioxane, n-hexane, cyclohexane, tetrahydrofuran, benzene, toluene and dimethylbenzene; and the reaction implementation is conventional heating. According to the method, 2-amino-nitrile compound is taken as a raw material and is blended with aldehyde under the action of alkali, thereby synthesizing the quinazoline-4-(3H)-ketone in one step. The method has the advantages that the raw material is easily obtained, the process is simple, the reaction condition is mild, the reaction application scope is wide, the post-processing is simple and different substrates can be used for synthesizing the quinazoline-4-(3H)-ketone.

The present invention is no-waste liquid cyclic process for preparing aromatic amino nitrile compound. The cyclic process synthesizes aromatic amino nitrile compound R1-NH-R2-CN by using aromatic amine compound R1-NH2 and hydroxyl alkyl nitrile compound HO-R2-CN as materials and in several combined cyclic systems, and has no waste liquid drainage. The cyclic process has full utilization of materials, saving in resource, high product yield, zero waste liquid drainage and other advantages, and is suitable for use in chemical industry.

The invention provides an improved preparing method of cis-counterpoint substituted cyclohexyl amino nitrile maleate shown in the formula (I). The method includes the steps of adding 0.3-0.55 molar fold of maleic acid to an organic solvent solution of a cis/trans-counterpoint substituted cyclohexyl amino nitrile compound corresponding to the formula (I) for stirring and ultrasonic treatment, and conducting filtering to obtain the cis-counterpoint substituted cyclohexyl amino nitrile maleate shown in the formula (I). In the formula (I), R1 represents a C1-C10 alkyl group or alkyl oxygroup, a C1-C10 vinyl group or vinyl oxygroup, a C1-C10 alkynyl group or alkynyl oxygroup, a C1-C10 naphthenic group or naphthenic oxygroup and a C1-C10 heterocyclic alkyl group or heterocyclic alkyl oxygroup with one or two heteroatoms selected from O and N, and HX represents maleic acid.

The invention discloses a preparation method of amino-nitrile and an intermediate for preparing glufosinate-ammonium. The preparation method disclosed by the invention aims at solving the problem of low glufosinate-ammonium yield by using acetal in the existing methods. Different from the existing methods for preparing glufosinate-ammonium, the method disclosed by the invention comprises the following steps: firstly reacting acetal with acetylchloride to obtain an enol ether intermediate, reacting the enol ether intermediate with sodium cyanide to obtain amino-nitrile, and finally hydrolyzing the amino-nitrile to obtain the glufosinate-ammonium. The method has the advantages of higher reaction yield and capacity of remarkably reducing the production cost of the glufosinate-ammonium.

The invention relates to a positive electrode additive of a lithium battery. The additive is modified maleimide modified by a combination containing amino-nitrile, annular alkali and annular acid; and after needle test on the battery prepared from the positive electrode additive, a result shows that the stability of the obtained positive electrode active material of the battery is greatly improved, and the cycle lifetime of the battery is prolonged. The positive electrode additive has the advantages that the used additive forms a protection film on the surface of the positive electrode active material, the positive electrode active material can be prevented from splitting during internal short circuit, and the battery is safer; and meanwhile, the good safe protection film is formed on the surface of the positive electrode active material, the service lifetime of the lithium battery is greatly prolonged, the cycle lifetime of the battery is also prolonged, and the self-discharging performance of the lithium battery is also greatly improved.

The invention discloses a preparation method of glufosinate-ammonium acid. The preparation method comprises the following steps: mixing glufosinate-ammonium amino nitrile with an alkali liquid for hydrolysis, and an absorbing produced ammonia gas with water; and adding oxalic acid into obtained hydrolysate for salt forming reaction; cooling a reaction liquid, filtering to obtain a filtrate and solid oxalate, concentrating the filtrate, adding alcohol into a concentrated liquid so as to separate solid glufosinate-ammonium acid, filtering, washing, and drying, so as to obtain the glufosinate-ammonium acid. According to the preparation method, glufosinate-ammonium amino nitrile is hydrolyzed by virtue of sodium hydroxide or calcium hydroxide and reacts with oxalic acid, ammonia generated through hydrolysis is deaminized through a micro-negative pressure and is absorbed with water so as to generate ammonia water, sodium oxalate or calcium oxalate is directly separated due to small water solubility or insoluble property, ammonium chloride is not generated in the whole preparation process, and the waste water quantity is extremely low. Prepared oxalate can be utilized for preparing oxalic acid again for circular use. The purity of prepared glufosinate-ammonium acid can reach above 96.5%, and the yield of prepared glufosinate-ammonium acid is more than or equal to 80%.

The invention provides a high-throughput screening method of nitrile invertase, which comprises the following steps of: dissolving a sample to be tested in distilled water; adding a substrate namely an amino-nitrile compound, a hydroxy-nitrile compound or an amide compound into the mixture until the concentration of the substrate is 1 to 100 mM; performing a conversion reaction in a water bath at the temperature of between 10 and 50 DEG C for 10 to 120 minutes; taking the conversion liquid, adding Fe2<+> ion aqueous solution and Fe3<+> ion aqueous solution into the conversion liquid successively to perform a color reaction, wherein the quantity ratio of the added substrate to the Fe2<+> to the F3<+> is 1:1-3:1-3, the time interval for adding the two ions is 0 to 10 minutes; and judging the type of the contained nitrile invertase according to color changes of the solution. The complex color reaction-based high-throughput screening method of the nitrile invertase can better overcome the defects of the conventional screening method, can quickly identify whether the tested sample has the nitrile hydratase, amidase or nitrilase through simple color contrasts, has the advantages of simple and convenient operation, quick detection, economical efficiency, practicability and the like, and greatly facilitates the quick screening of the nitrile hydratase, the amidase or the nitrilase.

Provided is a selective hydrogenation process for producing aminonitriles by contacting the corresponding dinitriles with a hydrogen-containing fluid in the presence of a hydrogenation catalyst, a solvent and divalent sulfur and selenium compounds.

The present invention comprises the simultaneous ring opening and concomitant N-substitution of various N-tosyl aziridines with different aliphatic and aromatic nitrites in presence of catalytic amount of metal triflates to afford different N-substituted beta-amino nitrites in excellent yields and selectivities.

The invention discloses a preparation method of 2-aminobutanamide hydrochloride, which comprises the following steps that: ammonium chloride, ammonia (30 percent) and sodium cyanide are added into aqueous solvent, and propyl aldehyde is dripped in at 5 to 10DEG C to react for 4 to 10h and to be extracted; organic phase is combined and dried; hydrogen chloride gas is fed in at room temperature until the pH value is 3 to 4, filtered to prepare 2-amino nitrile hydrochloride; and the product is dissolved in isopropanol, the temperature goes up, the hydrogen chloride gas is fed in until the solution is saturated, reaction is carried out for 4 to 5h, the product is cooled to room temperature and filtered, thereby a target product is obtained. The preparation method of 2-aminobutanamide hydrochloride has the advantages of mild reaction conditions, high yield, few by-products and the like.

The invention relates to a process for preparing an ethylene amine mixture, which comprises hydrogenating an amino nitrile mixture comprising at least 30% by weight of aminoacetonitrile (AAN) and at least 5% by weight of iminodiacetonitrile (IDAN) in the presence of a catalyst. Ethylenediamine (EDA) and/or diethylenetriamine (DETA) and, if appropriate, further ethylene amines can be isolated from the ethylene amine mixtures obtained.

The invention discloses a method for preparing alpha-aminonitrile, which comprises the following steps: by using tertiary amine and benzoyl cyanide as reactants, carrying out visible light irradiationin an organic solvent under the condition of oxygen or inert gas, and reacting at room temperature to obtain alpha-aminonitrile. The invention also discloses alpha amino nitrile and an application thereof. Visible light irradiation is used for promoting tertiary amine and benzoyl nitrile to react to prepare alpha-amino nitrile, a photocatalyst and a metal catalyst do not need to be additionally added, even alkali does not need to be added in some reactions, the reaction activity is high, the reaction conditions are mild, the reaction time is short, and the target product yield is high. According to the method, benzoyl nitrile is used as a cyanation reagent, so that the toxicity is low, the cost is low, and the industrial production of alpha-aminonitrile is facilitated.

The invention relates to a clean production method for amino acids such as iminodiacetic acid. The method comprises the steps: carrying out alkaline hydrolysis on amino-nitrile by adopting cheap lime cream, and carrying out deamination, so as to obtain an iminodiacetic acid calcium salt crude product; suspending the obtained iminodiacetic acid calcium salt crude product into water or mother liquor, adding sulfuric acid or other inorganic acid into the water or mother liquor for acidification, and filtering out an inorganic calcium salt filter cake with low water solubility; and subjecting the filter liquor to cooling and crystallization, carrying out separation so as to obtain iminodiacetic acid solids, and applying the crystallization mother liquor to an acidification reaction of next batch mechanically. During the acidification by the sulfuric acid, gypsum can be converted into calcium carbonate and ammonium sulfate by further using a byproduct, i.e., ammonia water of an alkaline hydrolysis process and carbon dioxide in flue gas, so as to directly generate compound fertilizers; the calcium carbonate can also be separated, and ammonium sulfate crystals can also be concentrated; and the calcium carbonate can be sold as a byproduct or be subjected to heated decomposition so as to obtain a quicklime raw material which can be applied mechanically. According to the novel process, the complete utilization of resources can be realized, the reaction selectivity is higher, the production of colored byproducts is reduced, and a concentrating process for removing waste salts such as sodium sulfate and sodium chloride and a wastewater treatment link are avoided; and due to concentration, the use level of a decolorant can be greatly lowered, the energy saving and consumption lowering effects are remarkable, and the production cost is reduced remarkably.

Provided is a selective hydrogenation process for producing aminonitriles by contacting the corresponding dinitriles with a hydrogen-containing fluid in the presence of a hydrogenation catalyst, a solvent and a quaternary ammonium cyanate additive.

The invention relates to a method for preparing an aminonitrile organic matter by a gas phase method, a graded reaction mode is adopted in the method, the hot-spot temperature rise of the catalyst is reduced, the service life of the catalyst is prolonged, and the selectivity and conversion rate of the reaction are improved; in addition, the method adopts a purification mode combining refining and adsorption, so that the purity of the 6-aminonitrile organic matter product is also remarkably improved on the basis of saving energy consumption, and the influence of impurities on downstream products is reduced.

The invention provides a preparation method of an alpha-amino-nitrile compound taking pyrrolidine tertiary amine as a primer. The preparation method comprises the following step of green synthesis ofalpha-amino-nitrile through a one-pot process by taking potassium ferrocyanide as a cyaniding reagent and an iodine phenyl compound as a reaction accelerant under the condition of a compound solvent containing trifluoroethanol and a catalyst. The invention provides the safer cyaniding reagent and an efficient synthetic method of alpha-amino-nitrile with mild reaction conditions. The preparation method is simple in post treatment, mild in reaction condition and short in reaction time, and develops a simple and efficient synthetic route for cyaniding synthesis of pyrrolidine tertiary amine.

The invention discloses a method for synthesizing N-fatty acyl group amino acid. With fatty acid ester and amino-nitrile adopted as the raw materials, and with sodium methylate or sodium ethoxide adopted as the catalyst, the method comprises the following steps: heating under nitrogen protection; adjusting the pH value to be acid; after refrigeration, filtering the reaction liquid; carrying out reduced pressure distillation on the obtained solid; collecting the cut fraction, and placing in alkali liquor for hydrolysis, so as to obtain N-fatty acyl group amino acid salt; or collecting the cut fraction, and carrying out acidification to prepare N-fatty acyl group amino acid. According to the method, amino-nitrile and fatty acid ester are adopted as the raw materials to prepare high purity N-fatty acyl group amino acid, the raw materials are cheap, the equipment is simple, and waste water generated during the production process is less.

A process and intermediates for producing 3-amino nitrites. The process involves resolving an enantiomeric mixture of chiral 3-amino nitrites in the presence of a chiral acid in a solvent system to produce a chiral 3-amino nitrile salt. The process may further comprise a recrystalizing step, wherein an enantiomerically enriched 3-amino nitrile salt is produced. The process may further comprise a salt exchanging step, wherein another acid is added to the chiral 3-amino nitrile salt or the enantiomerically enriched 3-amino nitrile salt to produce another 3-amino nitrile salt.

The invention relates to a process for preparing an amino nitrile mixture comprising aminoacetonitrile (AAN) and from 5 to 70% by weight of iminodiacetonitrile (IDAN), which comprises heating crude AAN which is largely free of formaldehyde cyanohydrin (FACH-free) at a temperature of from 50 to 150° C.

An optically active amino acid is useful as food or feed, agrochemicals, chemical products for industrial use, intermediates for synthesis of cosmetics or medicines and the like and is also important as optical resolving agents or chiral building blocks for use in organic synthesis. Thus, the object is to provide an industrially practical method for producing the optically active amino acid simply and at low cost. The method comprises the step of reacting an aminonitrile composed of a mixture of a D-aminonitrile and an L-aminonitrile with a biocatalyst which is one derived from a newly isolated microorganism belonging to the genus Rhodococcus and has an activity of converting the two aminonitriles into a D-amino acid amide and an L-amino acid amide respectively, a biocatalyst which has an activity of racemizing the D-amino acid amide and the L-amino acid amide to each other, and a biocatalyst which has an activity of converting one of the D-amino acid amide and the L-amino acid amide into the corresponding D- or L-amino acid.

Provided is a 3-aminomethyl-3,5,5-trimethylcyclohexylamine preparation method. A feeding flow of 3-cyano-3,5,5-trimethylcyclohexylimine is reacted with NH3 and hydrogen in the presence of a hydrogenation catalyst; the method is characterized by: firstly adding a basic compound to the feeding flow of 3-cyano-3,5,5-trimethylcyclohexylimine, and then after a portion of 3-cyano-3,5,5-trimethylcyclohexylimine has reacted, adding an acidic compound to reaction materials for further hydrogenation reaction to prepare the product. The method ensures that the aminonitrile content in the product is low, thus effectively reducing the duration of the reaction and greatly reducing the consumption of the catalyst during the hydrogenation reaction process.