Cis-para-substituted cyclohexylamino nitrile salt and preparation method therefor

Abstract

Provided are a cis-para-substituted cyclohexylamino nitrile salt as shown in formula (I) and a preparation method therefor, a use of said salt as a preparation intermediate for a pesticide such as spirotetramat, and a method for using said salt as an intermediate to prepare a pesticide such as spirotetramat. In formula (I), a para-substituent R is a C1-10 alkyl group or alkoxy group, a C1-10 alkenyl group or alkenyloxy group, a C1-10 alkynyl group or alkynyloxy group, a C1-10 cycloalkyl group or cycloalkoxy group, or a C1-10 heterocycloalkyl group or heterocycloalkoxy group containing 1-2 atoms selected from O and N, and HX is hydroxyacetic acid or maleic acid.

Description

technical field

[0001] The invention relates to a cis-para-substituted cyclohexylamino nitrile salt and a preparation method thereof, the use of the salt as an intermediate for preparing pesticides, and a method for preparing pesticides using the salt as an intermediate. Background technique

[0002] Chinese patent CN103270020B discloses cis-amino-4-alkoxycyclohexanecarbonitrile salt represented by the following formula:

[0003]

[0004] Wherein HX is hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, p-toluenesulfonic acid or methanesulfonic acid, R 1 is an alkoxy group.

[0005] However, the inventors of the present application have found that the three inorganic acids of hydrochloric acid, sulfuric acid and phosphoric acid used in CN103270020B are not selective, and cannot be selectively formed by the salt formation of these acids with amino-4-alkoxycyclohexanecarbonitrile The cis-isomer compound is separated by crystallization; acetic acid...

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