13 results about "Cycleanine dimethobromide" patented technology

A method for extracting and analyzing triazole fungicides using a switchable polarity deep eutectic solvent relates to the field of drinking water and food detection, and includes the following operation steps: a. adding a hydrophobic deep eutectic solvent to a sample solution to obtain a mixed solution A; the deep eutectic solvent is prepared from a hydrogen bond acceptor and a hydrogen bond donor; the hydrogen bond acceptor is one of dipropylamine, triethylamine, N,N-dimethylcyclohexylamine, and N,N-dimethylbenzylamine; the hydrogen bond donor is hexafluoroisopropanol; the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor is (2 to 1):(1 to 5); the volume ratio of the deep eutectic solvent to the sample solution is (0.04 to 0.08):1. This method also avoids the large-scale use of traditional organic solvents, follows the standards of contemporary green analytical chemistry, is sensitive, simple, and environmentally friendly, and is suitable for the detection and analysis of triazole insecticides in drinking water and beverages.

The invention provides a method for preparing 2, 6-dimethylaniline by depolymerizing and aminating polyphenyl ether, which comprises the following steps: reacting polyphenyl ether, hydrogen and ammonia gas dispersed in an organic reaction medium under the action of a Pt-based catalyst at a first temperature for a first time to obtain 2, 6-dimethyl cyclohexylamine; adding a hydrogen trapping agent, and reacting at a second temperature for a second time under the action of a nitrogen atmosphere and a Pt-based catalyst to obtain 2, 6-dimethylaniline; wherein the Pt-based catalyst comprises a carrier and Pt loaded on the carrier, and the carrier is selected from at least one of metal oxide, SiO2 and activated carbon; and the particle size of Pt is 0.6 nm to 1.8 nm. The novel method for depolymerizing and aminating PPO into 2, 6-dimethylaniline through a two-step method not only provides a new thought for recovery and upgrading of PPO waste plastics, but also provides a new direction for synthesis of aromatic amines such as 2, 6-dimethylaniline with high added value.

The invention provides nano aerogel and a preparation method thereof, and relates to the technical field of material science and engineering.The nano aerogel comprises glue A and glue B. The glue A comprises polyether polyol (polypropylene glycol type), N, N-dimethyl cyclohexylamine, pentamethyldiethylenetriamine, dipropylene glycol, triethyl phosphate, diethylene glycol monomethyl ether, tris (2-chloropropyl) phosphate and phthalocyanine blue, and the glue B comprises polyether polyol (polypropylene glycol type), N, N-dimethyl cyclohexylamine, pentamethyldiethylenetriamine, dipropylene glycol, triethyl phosphate, diethylene glycol monomethyl ether, tris (2-chloropropyl) phosphate and phthalocyanine blue. The adhesive B comprises 4, 4 '-methylene bis (phenyl isocyanate) and a phenyl isocyanate prepolymer, and the adhesive A comprises the following components in parts by mass: 80 parts of polyether polyol (polypropylene glycol type), 1 part of N, N-dimethyl cyclohexylamine, 0.5 part of pentamethyldiethylenetriamine, 4 parts of dipropylene glycol, 5 parts of triethyl phosphate, 4 parts of diethylene glycol monomethyl ether, 5 parts of tris (2-chloropropyl) phosphate and 0.5 part of phthalocyanine blue. The prepared nano aerogel has an extremely low heat conductivity coefficient, can effectively prevent heat transfer, provides an excellent heat insulation effect for buildings, industrial equipment and the like, and reduces energy consumption.

The application discloses a synthesis method of 3-aminomethyl-3,5,5-trimethylcyclohexylamine. The method comprises the following steps: 1) taking 3-cyano-3,5,5-trimethylcyclohexylimine and hydrogen as raw materials, and performing imine hydrogenation reaction in a solvent in the presence of a first catalyst and a first cocatalyst to obtain 3-cyano-3,5,5-trimethylcyclohexylamine; 2) taking 3-cyano-3,5,5-trimethylcyclohexylamine and hydrogen as raw materials, and performing cyano hydrogenation reaction in an organic solvent in the presence of a second catalyst and a second cocatalyst to obtain a target product; the first catalyst contains one or both of nickel and cobalt; the first cocatalyst is a substance capable of reacting with hydrogen cyanide; the second catalyst contains iron; and the second cocatalyst is a Lewis acid catalyst. The synthesis method can obviously improve the yield and purity of the target product, the catalyst is more stable, the cost is lower, and the synthesis method is more environmentally friendly.

This invention relates to the field of pharmaceutical analysis technology, and provides a method for detecting N-methylcyclohexylamine hydrochloride in bromhexine hydrochloride. The method involves dissolving N-methylcyclohexylamine in an organic solvent as a reference solution, and dissolving bromhexine hydrochloride in an organic solvent containing an acid-binding agent as the test solvent, followed by headspace gas chromatography for detection. This method is simple, efficient, specific, sensitive, repeatable, and stable, and can be used for the quality control of bromhexine hydrochloride raw material, providing technical support for its production.

This invention discloses a method for synthesizing bromhexine hydrochloride, with the following specific steps: Step (1), using 2-amino-3,5-dibromobenzoic acid as a raw material, reacting it with trimethylacetyl chloride via an anhydride method under the action of an acid-binding agent to obtain compound 2-amino-3,5-dibromobenzoic acid anhydride; Step (2), the 2-amino-3,5-dibromobenzoic acid anhydride obtained in Step 1 undergoes nucleophilic addition with N-methylcyclohexylamine to obtain compound 5, bromhexine hydrochloride intermediate; Step (3), the above compound 5, bromhexine hydrochloride intermediate undergoes amide reduction and salt formation reaction to obtain bromhexine hydrochloride. This process provides a new route for preparing bromhexine hydrochloride, avoiding the heavily regulated chlorination process, reducing the release of toxic gases from strong halogen reagents such as thionyl chloride, significantly reducing safety risks and environmental protection investment, and the reaction itself is safe and fast, which is conducive to industrial production.

The application discloses a preparation method of N,N-dimethylcyclohexylamine with improved storage stability, which comprises the following steps: reacting cyclohexylamine, N,N-dimethylcyclohexylamine, formaldehyde and hydrogen under the action of a supported palladium-based catalyst; in the raw materials, the addition amount of N,N-dimethylcyclohexylamine is 1-5% of the mass of the cyclohexylamine, preferably 2-3%. The N,N-dimethylcyclohexylamine can be prepared at a high yield by the method, and the content of N-cyclohexylformamide impurities can be controlled to be below 10 ppm, and it is found that the low-temperature storage stability is significantly improved.

The embodiment of the invention provides a preparation method of N-(2-methylcyclohexyl)-2, 3, 4, 5, 6-pentafluorobenzamide, atomized liquid and an atomization device, pentafluorobenzoic acid and 2-methylcyclohexyl amine can be subjected to a synthetic reaction in an organic solvent under the action of an alkaline substance and a condensing agent to generate N-(2-methylcyclohexyl)-2, 3, 4, 5, 6-pentafluorobenzamide, and the atomized liquid is used for preparing N-(2-methylcyclohexyl)-2, 3, 4, 5, 6-pentafluorobenzamide. The method comprises the following steps: dissolving a target product crude product of N-(2-methylcyclohexyl)-2, 3, 4, 5, 6-pentafluorobenzamide into ethanol, filtering in a second mixed solution, dissolving in ethanol, decolorizing with activated carbon, carrying out hot filtration, adding water into a filtrate to precipitate a solid, filtering, and drying filter residues, thereby obtaining N-(2-methylcyclohexyl)-2, 3, 4, 5, 6-pentafluorobenzamide with the purity of greater than or equal to 99%, namely N-(2-methylcyclohexyl)-2, 3, 4, 5, 6-pentafluorobenzamide with the purity of greater than or equal to 99%. The method can effectively solve the problem that high-purity N-(2-methylcyclohexyl)-2, 3, 4, 5, 6-pentafluorobenzamide cannot be effectively synthesized in the prior art.

The invention discloses a synthesis method of bromhexine hydrochloride, particularly relates to the technical field of chemical drug synthesis, and relates to a synthesis method of bromhexine hydrochloride. The bromhexine hydrochloride is composed of an aniline derivative and N-methylcyclohexylamine; the bromhexine hydrochloride is prepared from the following raw materials in parts by weight: 3-5 parts of aniline derivative and 6 parts of N-methylcyclohexylamine. According to the Grignard reagent-coupling-salifying method disclosed by the invention, the key intermediate is directly synthesized through one-step coupling reaction, and then the target product can be obtained through salifying reaction, so that the reaction steps are relatively few, the treatment and conversion time of the intermediate is shortened, and the synthesis route is remarkably simplified.

Thermoresponsive, switchable-hydrophilicity amine solvents such as diisopropylamine (DIPA), N,N-dimethylcyclohexylamine (DMCHA), dipropylamine (DPA), N-ethylcyclohexylamine (ECHA), triethylamine (TEA), and tert-octylamine (TOA) are used to extract lithium from hypersaline brines. The solvent is mixed with hypersaline brines containing lithium and other alkali metal cations at an extraction temperature. The result is a multi-phase mixture including a light, organic extract phase above a heavy, aqueous raffinate phase. Water and salt partitions from the aqueous phase into the organic phase, and lithium is preferentially partitioned over other alkali metal cations, enabling ion-specific separation. The extract is separated from the raffinate and warmed to a disengagement temperature. At higher temperatures, phase disengagement occurs as the substantially all previously extracted ions and water demix from the organic phase, yielding an aqueous product water stream containing the extracted cations and enriched with lithium. The regenerated solvent can be recycled for use in treatment of additional feed brine.

The present application relates to a kind of preparation methods of 3-aminomethyl-3,5,5-trimethylcyclohexane.The preparation method includes: isophorone nitrile, ammonia and hydrogen peroxide occur in the presence of modified titanium silicon catalyst and generate intermediate 1, and the obtained intermediate 1 occurs in the presence of hydrogenation catalyst and hydrogenation reaction generates 3-aminomethyl-3,5,5-trimethylcyclohexylamine.The method described in the present application can be operated at lower reaction pressure, reaction step is simple, yield is high, product is easy to purify and separate, and is suitable for industrial production.

The invention relates to the technical field of polyurethane materials, in particular to a light polyurethane shoe material for sports shoes and a preparation process thereof, and the light polyurethane shoe material comprises the following components: 40-60 parts by weight of polyether polyol, 20-40 parts by weight of hexamethylene diisocyanate, 20-40 parts by weight of N, N-dimethylformamide, 1-5 parts by weight of a coupling agent, 1-5 parts by weight of an antioxidant, 1-5 parts The invention relates to a flame-retardant and flame-retardant material which is prepared from the following components in parts by weight: 0.5-1.5 parts of N, N-dimethyl cyclohexylamine, 5-15 parts of modified p-toluenesulfonhydrazide microcapsules, 1-3 parts of a nucleating agent, 0.5-2 parts of zinc dialkyl dithiophosphate, 0.5-2 parts of phenyl salicylate and 0.5-2 parts of polyoxyethylene sorbitan monooleate. The aryl halide can improve the thermal decomposition temperature of p-toluenesulfonyl hydrazide, so that the p-toluenesulfonyl hydrazide is not easy to decompose in advance under a high-temperature processing condition, and the foaming process can be accurately controlled. Due to the fact that the fatty acid can reduce the surface tension of the system, gas can form tiny bubble nucleuses in the system more easily, the number of bubble nucleation sites is increased, a more fine and uniform bubble structure can be generated, and the buffering performance and the overall quality of the shoe material are improved.

The invention discloses a low-silicon SAPO-34 molecular sieve as well as a synthesis method and application thereof. The chemical composition of the low-silicon SAPO-34 molecular sieve is mR < 1 >. NR < 2 >. (Si < x > Al < y > P < z >) O < 2 >, wherein R < 1 > and R < 2 > are template agents; m is equal to 0.01 to 0.15, n is equal to 0.0 to 0.10, x is equal to 0.01 to 0.07, y is equal to 0.35 to 0.50, z is equal to 0.35 to 0.50, and x + y + z is equal to 1; r1 is at least one of diethylamine, triethylamine, di-n-propylamine, diisopropylamine, n-butylamine, morpholine, cyclohexylamine, piperazine and tetraethylammonium hydroxide; r2 is at least one of polyamines such as N, N '-dimethylethylenediamine, N, N'-dimethyl-1, 3-propane diamine, N, N '-dimethyl-1, 4-butanediamine, N, N'-dimethyl-cyclohexylamine and the like; the method is simple in process, good in repeatability and suitable for large-scale industrial production.