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Medicine composition for treating age-related macular degeneration and pharmaceutical purpose of medicine composition

A kind of senile macula and composition technology, applied in the field of traditional Chinese medicine, can solve problems such as normal tissue damage, achieve the effects of improving vision, reducing bleeding, and less incidence of adverse reactions

Inactive Publication Date: 2016-03-09
王亚鹤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, common treatment methods include: laser therapy, transpupillary diathermy, photodynamic therapy, intravitreal injection of anti-VEGF drugs, etc., but it will inevitably cause certain damage to normal tissues, and there are certain limitations.

Method used

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  • Medicine composition for treating age-related macular degeneration and pharmaceutical purpose of medicine composition
  • Medicine composition for treating age-related macular degeneration and pharmaceutical purpose of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of Chinese medicine extract

[0013] Weigh 2.8kg of kudzu root, 2.8kg of rhododendron, 1.5kg of suona flower, 1.2kg of spinach seed, 1.2kg of poria cocos, 1.2kg of earthworm, 2.8kg of astragalus, 0.5kg of yellow daphne flower and 1.0kg of seaweed, combine, crush, and add water to diffuse the medicine Noodle 2cm, soak for 1-1.2h, take out the medicinal materials, put them in a multi-functional extraction tank, add water and decoct twice, add 10 times the amount of purified water for the first time, boil and decoct for 2 hours, take the decoction, filter For the second time, add 8 times the amount of purified water to the medicinal materials, boil and decoct on low heat for 1.5 hours, take the two decoctions and combine them, filter, concentrate to contain 1.2g crude drug per ml, stir evenly, and refrigerate at 5°C After 24 hours, the refrigerated solution was filtered, heated and concentrated to a thick paste, dried, and pulverized to obtain...

Embodiment 2

[0014] Embodiment 2: the preparation of Chinese medicine tablet

[0015]

[0016] Preparation method: take the dry powder of traditional Chinese medicine extract (prepared according to the formula process of Example 1) of the prescribed amount, pass through 100 mesh to dry, then add dextrin and sucrose that crossed 80 mesh sieve, mix evenly, add an appropriate amount of 75% The ethanol solution is used as a binder, and the wet granulation method is adopted, that is, the wet granules are made through a 32-mesh sieve, and the wet granules are fully dried at 45-60°C, and the granules are sized. The dry granules are added with talcum powder, mixed evenly, and compressed by a tablet machine. Get Chinese medicine tablets.

Embodiment 3

[0017] Example 3: Experimental study on the curative effect of traditional Chinese medicine on wet age-related macular degeneration

[0018] After diagnosis, 41 patients with wet age-related macular degeneration (58 eyes), 21 males and 20 females, aged 55 to 82 years, with an average (65.9±5.5) years old, were randomly divided into two groups, 21 cases (29 eyes), and 20 cases (29 eyes) in the control group. There was no significant difference in gender, age, course of disease and condition between the two groups of patients, and they were comparable. After the test started, the patients in the control group took vitamin E pills 0.1g, 2 times / d; vitamin C tablets 0.2g, 3 times / d; zinc gluconate tablets 70mg, 3 times / d. The patients in the test group took orally the traditional Chinese medicine prescription of the present invention, and the prescription consisted of: 28g of Pueraria chinensis root, 28g of Rhododendron 28g, 15g of Suona flower, 12g of spinach seed, 12g of Poria ...

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Abstract

The invention discloses a medicine composition for treating age-related macular degeneration and a pharmaceutical purpose of the medicine composition. The medicine composition is prepared from the following traditional Chinese medicinal materials in parts by mass through water decoction extraction: 25 to 33 parts of oriental grape roots, 25 to 33 parts of rhododendron pulchrum, 11 to 20 parts ofIncarvillea arguta, 9 to 15 parts of spinach seeds, 9 to 15 parts of Poria , 9 to 15 parts of earthworm, 25 to 33 parts of Radix Astragali seu Hedysari, 3 to 6 parts of folium et flos wikstroemiae chamaedaphnis and 7 to 13 parts of varech. The medicine composition provided by the invention has good effects in aspects of improving the eyesight, reducing the bleeding and stabilizing the exudation; the pathological change development can be controlled; the adverse reaction occurrence rate in the observation process is reduced; the effectiveness and the safety are better; the medicine composition is particularly suitable for being used for treating wet age-related macular degeneration.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating age-related macular degeneration and its pharmaceutical application. Background technique [0002] Age-related macular degeneration is a geriatric disease whose incidence increases with age. Clinically, it can be divided into dry and wet age-related macular degeneration. Wet age-related macular degeneration is a fundus lesion that seriously threatens the visual function of the elderly, and the formation of choroidal neovascularization is one of the main factors causing blindness. At present, common treatment methods include: laser therapy, transpupillary diathermy, photodynamic therapy, intravitreal injection of anti-VEGF drugs, etc., but they inevitably cause certain damage to normal tissues and have certain limitations. Contents of the invention [0003] In view of the deficiencies of Western medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P27/02A61K35/62
CPCA61K36/87A61K9/2059A61K35/62A61K36/03A61K36/076A61K36/185A61K36/45A61K36/481A61K36/83A61K2236/331
Inventor 王亚鹤
Owner 王亚鹤
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