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Qi-regulating and heart-soothing tablet and preparation method thereof

A technology for shortness of breath and coronary heart disease, applied in the field of Liqi Shuxin tablets and its preparation, can solve the problems of low curative effect, unsatisfactory curative effect, slow disintegration, etc.

Inactive Publication Date: 2016-03-09
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of Liqi Shuxin Tablets on the market is not ideal due to the composition and process. The preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect.

Method used

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  • Qi-regulating and heart-soothing tablet and preparation method thereof
  • Qi-regulating and heart-soothing tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take Gastrodia elata 33g, Xiangshu 28.5g, Angelica 66g, Poria 57g, Cymbidium 57g, Curcuma 75g, Puhuang 20g, Bergamot 85g, tangerine peel 66.6g, Citrus aurantium 60g, green peel 88g, Citrus aurantium 60g, malt (fried) 120g, incense Citrine 111g, Salvia miltiorrhiza 20g, crushed into 60-mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 24Mpa, extraction temperature 23°C, separator pressure 10Mpa, separator temperature 38°C, separation time 1.8 hours, carbon dioxide flow rate per hour 20L to obtain an extract; take the extract and dry it under reduced pressure at 62°C to obtain a dry paste; add 80 g of citric acid to the dry paste, and pulverize it into a mixed dry paste powder with a particle size of 200-300 nm by using a high-energy nano-impact mill; take the mixed dry paste Powder, microcrystalline cellulose 35g, hypromellose 35g, croscarmellose sodium 35g, magnesium aluminum silicate 15g, sodium chloride 5g, mannitol 4g, malto...

specific Embodiment 2

[0039]Take Gastrodia elata 33g, Xiangshu 28.5g, Angelica 66g, Poria 57g, Cymbidium 57g, Curcuma 75g, Puhuang 20g, Bergamot 85g, tangerine peel 66.6g, Citrus aurantium 60g, green peel 88g, Citrus aurantium 60g, malt (fried) 120g, incense Citrine 111g, Salvia miltiorrhiza 20g, crushed into 60-mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 39Mpa, extraction temperature 43°C, separator pressure 19Mpa, separator temperature 59°C, separation time 3.7 hours, carbon dioxide flow rate per hour 36L to obtain an extract; take the extract and dry it under reduced pressure at 78°C to obtain a dry paste; add 120 g of citric acid to the dry paste, and pulverize it into a mixed dry paste powder with a particle size of 200-300 nm by using a high-energy nano-impact mill; take the mixed dry paste Powder, microcrystalline cellulose 45g, hydroxypropyl cellulose 45g, croscarmellose sodium 45g, magnesium aluminum silicate 25g, sodium chloride 15g, mannit...

Embodiment 3

[0041] Take Gastrodia elata 33g, Xiangshu 28.5g, Angelica 66g, Poria 57g, Cymbidium 57g, Curcuma 75g, Puhuang 20g, Bergamot 85g, tangerine peel 66.6g, Citrus aurantium 60g, green peel 88g, Citrus aurantium 60g, malt (fried) 120g, incense Citrine 111g, Salvia miltiorrhiza 20g, crushed into 60-mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 36Mpa, extraction temperature 33°C, separator pressure 15Mpa, separator temperature 49°C, separation time 2.8 hours, carbon dioxide flow rate per hour 28L to obtain an extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 100 g of citric acid to the dry paste, and pulverize it into a mixed dry paste powder with a particle size of 200-300nm using a high-energy nano-impact mill; take the mixed dry paste Powder, microcrystalline cellulose 40g, hydroxypropyl cellulose 40g, croscarmellose sodium 40g, magnesium aluminum silicate 20g, sodium chloride 10g, mannitol ...

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Abstract

The invention discloses a qi-regulating and heart-soothing tablet and a preparation method thereof. The preparation method of the qi-regulating and heart-soothing tablet is characterized by comprising the following steps of taking 33g of gastrodia tuer, 28.5g of elsholtzia ciliata, 66g of Chinese angelica, 57g of tuckahoe, 57g of nutgrass galingale rhizome, 75g of zedoary, 20g of cattail pollen, 85g of citrus medica sarcodactylis, 66.6g of dried orange peel, 60g of fructus aurantii immaturus, 88g of pericarpium citri reticulatae viride, 60g of fructus aurantii, 120g of fried malt, 111g of citrus medica and 20g of salvia miltiorrhiza; extracting by adopting a supercritical carbon dioxide extraction method; drying under reduced pressure; crushing the mixture into a nano dry paste by using a high-energy nano impact mill; adding functional auxiliary materials to prepare the qi-regulating and heart-soothing tablet. The disintegration time is remarkably shortened; the curative effect of the qi-regulating and heart-soothing tablet is significantly superior to that of a commercially available qi-regulating and heart-soothing tablet , and positive effects are obtained.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Qi-regulating Shuxin tablet and a preparation method thereof. Background technique [0002] Liqi Shuxin Tablet relieves liver stagnation, promotes qi stagnation, and relieves chest pain. For coronary heart disease, angina pectoris, arrhythmia, shortness of breath and abdominal distension, chest tightness and palpitations. The commercially available Liqi Shuxin Tablets have unsatisfactory curative effect due to formulation and technological reasons, and the preparations are prepared by traditional techniques, which have disadvantages such as delayed disintegration and low curative effect. SUMMARY OF THE INVENTION [0003] In order to overcome the above deficiencies, the present invention provides a Liqi Shuxin tablet with fast disintegration speed and high curative effect and a preparation method thereof. [0004] The embodiments of the invention are as follows: ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61P9/10A61P9/06
CPCA61K36/8988A61K9/2009A61K9/205A61K36/076A61K36/232A61K36/53A61K36/537A61K36/752A61K36/88A61K36/8905A61K36/8998A61K36/9066A61K2236/37A61K2236/51
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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