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Application of Epishionol in preparing drugs for treating lung cancer

A drug and lung cancer technology, applied in the application field of Epishionol in the preparation of drugs for the treatment of lung cancer, can solve problems such as damage to normal tissues and cells, and achieve the effect of strong cytotoxicity and outstanding substantive characteristics.

Inactive Publication Date: 2016-03-23
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application.

Method used

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  • Application of Epishionol in preparing drugs for treating lung cancer
  • Application of Epishionol in preparing drugs for treating lung cancer
  • Application of Epishionol in preparing drugs for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of compound Epishionol tablet involved in the present invention:

[0016] Take 5 grams of the compound Epishionol, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0017] Embodiment 2: the preparation of the compound Epishionol capsule involved in the present invention:

[0018] Get 5 grams of compound Epishionol, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0019] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0020] Experimental example: the inhibitory effect of Epishionol on the proliferation of lung cancer cells cultured in vitro and the effect on normal human cells

[0021] Lung cancer cells in logarithmic growth phase (non-small cell lung cancer cell A549, large cell lung cancer cell NCI-H460, lung squamous cell carcinoma cell HTB-8 and human lung squamous cell carcinoma cell QG-5) and human normal liver cell L02 were inoculated in On a 96-well culture plate, the inoculum volume per well was 3000-4000 / 100uL and 6000 / 100uL respectively; 15 mL of venous blood from healthy blood donors was aseptically collected, anticoagulated with heparin, and mononuclear cells were separated by Ficoll density gradient centrifugation. Prepare a single cell suspension with RPMI1640 containing 10% fetal bovine serum, adjust the cell concentration to 2×105 cells / mL, inoculate in a 96-well culture plate, 100 uL per well. After 24 hours of cell culture on each of the above-mentioned culture plates, th...

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PUM

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Abstract

The invention discloses the application of Epishionol in preparing drugs for treating lung cancer and belongs to the technical field of novel application of drugs. The compound has high anti-lung-cancer activity and can be used for preparing drugs for treating lung cancer. Epishionol can remarkably restrain in-vitro cultured non-small cell lung cancer cells A549, large cell lung cancer cells NCI-H460, lung squamous carcinoma cells HTB-8 and human lung epidermoid carcinoma cells QG-5, and has a small restraining effect on human normal hepatic cells LO2 and peripheral blood lymphocytes, and remarkable selectivity is realized. The application of Epishionol in preparing drugs for treating lung cancer is disclosed for the first time, a novel framework type is adopted, and the lung cancer cell inhibitory activity of Epishionol is surprisingly high.

Description

technical field [0001] The present invention relates to a new application of compound Epishionol, in particular to the application of Epishionol in the preparation of drugs for treating lung cancer. Background technique [0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application. It has become the direction and urgent task of current anticancer drug research to find highly efficient and low toxic drugs for treating tumors. Finding high-efficiency, low-toxic anticancer drugs has been considered an effective way. [0003] The present invention has confirmed by experiments that Epishionol has significant inhibitory effect on non-small cell lung cancer cell A549, large cell lung cancer cell NCI-H460, lung squamous cell carcinoma cell HTB-8 and human lung squamous cell carcinoma cell QG-5 cultured in v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P35/00A61P11/00
CPCA61K31/56A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD