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Production method of Relinqing preparation

A production method, the technology of Relinqing, is applied in the fields of pill delivery, pharmaceutical formula, and medical preparations containing active ingredients, etc., and can solve problems such as difficult detection of Polygonum cephalosporin and unsatisfactory clinical curative effect of Relinqing, and achieve the goal of medicine Significant effect, easy to measure, and improve the effect of drug efficacy

Inactive Publication Date: 2016-03-30
GUIZHOU HONGKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor found in the research process that gallic acid, the active ingredient of Polygonum cephalum, is not easy to detect in the Relinqing made by the existing extraction process.
The clinical curative effect of Relinqing is not ideal enough

Method used

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  • Production method of Relinqing preparation
  • Production method of Relinqing preparation
  • Production method of Relinqing preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Take Polygonum cephalum, cut into sections, add 10 times the amount of 65% ethanol to reflux and extract 4 times, each time for 1.5 hours, combine the filtrate, filter, and recover the ethanol from the filtrate under reduced pressure. When concentrated to 60-70 ° C, the relative density is 1.10- The thick paste of 1.20 is vacuum-dried to obtain a dry paste, dried, and pulverized into powder; another microcrystalline cellulose, starch and magnesium stearate are mixed to obtain a mixture, and 5% of the mixture is added to the mixture The water is stirred into a paste, used as an adhesive, the adhesive is mixed with the powder, 75% ethanol is added in an amount 0.3 times the amount of the mixed powder, granulated, and packed into capsules to obtain capsules.

[0071] Usage and dosage: take orally, 3-4 capsules at a time, 3 times a day.

[0072] Specification: 0.35g / grain.

[0073] Storage: sealed.

Embodiment 2

[0075] Take Polygonum cephalum, cut into sections, add 10 times the amount of 65% ethanol to reflux and extract 4 times, each time for 1.5 hours, combine the filtrate, filter, and recover the ethanol from the filtrate under reduced pressure. When concentrated to 60-70 ° C, the relative density is 1.10- The thick paste of 1.20 is vacuum-dried to obtain a dry paste, dried, and pulverized into powder; another microcrystalline cellulose and starch are mixed to obtain a mixture, and 5% of the water of the mixture is added to the mixture and stirred to form a paste , as a binder, the binder is mixed with the powder, 75% ethanol is added to 0.3 times the amount of the mixed powder, granulated, dried, and compressed to obtain a tablet.

[0076] Usage and dosage: take orally, 3-4 tablets at a time, 3 times a day.

[0077] Specification: 0.35g / piece.

[0078] Storage: sealed.

Embodiment 3

[0080] Take Polygonum cephalum, cut into sections, add 10 times the amount of 65% ethanol to reflux and extract 4 times, each time for 1.5 hours, combine the filtrate, filter, and recover the ethanol from the filtrate under reduced pressure. When concentrated to 60-70 ° C, the relative density is 1.10- 1.20 thick paste, add 50% sucrose powder, granulate, and dry to obtain granules.

[0081] Usage and dosage: take orally, 5-10g each time, 3 times a day.

[0082] Specifications: 5g / bag.

[0083] Storage: sealed.

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Abstract

The invention discloses a production method of a Relinqing preparation. The Relinqing preparation is prepared from Polygonum capitatum and auxiliary materials. According to properties of various medicinal materials in a formula of the Relinqing preparation as well as roles of the medicinal materials in the formula, the specific production method and parameters of the Relinqing preparation are improved, so that gallic acid used as an effective ingredient of the Polygonum capitatum can be detected easily, and the content of the measured gallic acid is high. Thus, the preparation is more refined and has the more significant efficacy and the good clinical effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method of Relinqing preparation. Background technique [0002] Extraction of traditional Chinese medicine is a commonly used method in traditional Chinese medicine pharmacy. The chemical composition of traditional Chinese medicine is extremely complex, and it is necessary to extract the active ingredients of traditional Chinese medicine that are effective for the human body from the complex mixture. to improve efficacy. [0003] Relinqing is mainly made from Polygonum cephalum. It has the functions of clearing away heat and purging fire, promoting fire and treating stranguria. For hot shower embolism. [0004] In the prior art, Relinqing is made in this way: take Polygonum cephalum, cut into sections, add water to boil twice, each time for 1.5 hours, combine the decoction, let it stand, filter, the filtrate is concentrated into a thick pas...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P13/00
CPCA61K36/704A61K9/1623A61K9/1652A61K9/2059A61K9/2068A61K2236/333A61K2236/39A61K2236/51
Inventor 龙凤荣王瑶李珂孙敏
Owner GUIZHOU HONGKANG PHARMA
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