Implantable intracranial drug delivery cannula suitable for neurosciences research

Abstract

The invention discloses an implantable intracranial drug delivery cannula suitable for neurosciences research. The drug delivery cannula comprises a microprocessor, a reflective mirror, a fixing support, an inner cavity, a first drug delivery pipe, a seal sleeve, a second drug delivery pipe and an intracranial body; a drug delivery cannula outlet and a drug delivery hole formed in the drug delivery cannula outlet are formed in one end of the first drug delivery pipe, the inner cavity is formed in the first drug delivery pipe, light guiding fibers are arranged between the inner cavity and the inner side of the first drug delivery pipe, and the reflective mirror is arranged at one ends of the light guiding fibers; the microprocessor is arranged at the other end of the first drug delivery pipe, one side of the first drug delivery pipe is provided with the second drug delivery pipe and a drug delivery cannula inlet formed in one end of the second drug delivery pipe, and the drug delivery cannula inlet is sleeved with the seal sleeve. According to the implantable intracranial drug delivery cannula suitable for neurosciences research, a cannula material mets the requirement of medical implantation, fixity and leakproofness are good, and a cannula inner core is high in operability and intellectuality.

Description

Technical field [0001] The invention relates to the technical field of medical equipment, in particular to an implantable intracranial drug delivery cannula suitable for neuroscience research. Background technique [0002] At present, the technology of intracranial intubation applied to brain science research in China is still immature. Various universities or research institutions use self-made intracranial cannula for scientific research. However, self-made cannula has many disadvantages, such as: (1 ) The intubation material does not meet the requirements of medical implants: general industrial steel pipes are used as implant tubing materials, which cannot meet the physical and chemical stability requirements of medical and biological implants. It releases harmful metal or non-metal ions in the brain. Cause the nerve cells to work abnormally or pathologically necrosis, (2) Poor fixation: The self-made intracranial cannula does not have a fixed base structure. From a mechanical...

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Problems solved by technology

[0002] At present, the technology of intracranial intubation applied to brain science research in China is still immature. Every university or research institution uses self-made intracranial intubation for scientific research. However, self-made intubation has many shortcomings, for example: (1 ) The intubation material does not meet the requirements of medical implants: the use of general industrial steel pipes as implants cannot meet the physical and chemical stability requirements of medical and biological implants, and it releases harmful metal or non-metal ions in the brain. Causes abnormal work of nerve cells or necrosis of lesions. (2) Poor fixation: self-made intracranial cannula has no fixed base structure. From a mechanical point of view, the fixation between the cannula and the skull is relatively fragile. During chronic experiments, due to the deformation and aging of the fixing glue or dental cement, the cannula is easily displaced or directly falls off from the surface of the skull. (3) Poor airtightness: self-made cannula basically has no sealing cap structure, and cannot well seal the intracranial and The extracranial environment is strictly and effectively isolated. Microbes entering the brain and causing intracranial infection are serious shortcomings that are difficult to overcome by self-made cannula. (4) The inner core of the cannula is poorly operable: the filling inner core of the self-made cannula is only found by the experimenter. Metal tubes that are thinner than the inner diameter of the cannula not only have physical and chemical stability problems, leading to toxic reactions or degradation and rust, but also more difficult to satisfy, the diameter is difficult to meet the ideal requirements, resulting in after the cannula is implanted, The cerebrospinal fluid in the brain can exist in a large amount between the inner core and the cannula wall due to hair suction, and once the abundant protein and inorganic salts in the cerebrospinal fluid are precipitated, it is very easy to play the role of adhesive, sticking the cannula and the inner core. Taken together, it makes it difficult to take out the inner core. This phenomenon is more common in self-made intubation. (5) The intelligence is poor. During the administration process, the medical staff cannot understand the patient's intracranial situation. measures, for this purpose, we propose an implantable intracranial drug delivery cannula suitable for neuroscience research

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