54 results about "Neuroscience research" patented technology

Apparatus and methods in which very small volumes of material may be extracted, delivered, interrogated or stimulated via optical, electromagnetic or mechanical means, in vivo or in vitro, for site-specific detection, characterization, stimulation, diagnostics or therapy, comprising optical, fluidic, chemical, electromagnetic and biological techniques applied via a microprobe in a single intra-parenchymal tissue perforation procedure in the brain. The primary use of the device is in neuroscience research, clinical diagnostics and therapeutics applications in the brain, however, the device may also be beneficially applied to other organs and biological systems. Human clinical applications may include neurosurgical intra-operative monitoring, extra-operative chronic monitoring of devices introduced in an operation, and diagnostic monitoring combined with simultaneous neuroimaging.

The invention discloses a psychological assessment system. The system comprises at least one mobile terminal client, at least one brain wave testing instrument and a data server, wherein the mobile terminal client is used for collecting psychological assessment data of subjects and displaying a psychological assessment result to the subjects; the brain wave testing instrument is used for monitoring brain wave data of the subjects and transmitting the brain wave data to the mobile terminal client; the brain wave testing instruments and the mobile terminal clients are the same in number and are in one-to-one correspondence in a wireless manner; and the data server is used for obtaining the psychological assessment data and the brain wave data from the mobile terminal client, obtaining the psychological assessment result through statistical processing and analysis and transmitting the psychological assessment result to the mobile terminal client. The psychological assessment system disclosed by the invention can be applied to criminal investigation, neuroscience research, psychotherapy and so on and can be also applied to psychological investigation of population within a large range; the accuracy and effectiveness of the psychological assessment can be effectively enhanced; and information processing efficiency is increased.

The invention discloses a transcranial magnetic stimulation device controlled by near-infrared signals. The TMS stimulation system and the fNIRS signal acquisition system are described above. The present invention utilizes the near-infrared signals of the subjects themselves to set personalized transcranial magnetic stimulation parameters, avoiding excessive stimulation or insufficient stimulation. The present invention is simple and easy to operate, convenient to adjust the transcranial magnetic stimulation parameters according to the real-time near-infrared signal in the transcranial magnetic stimulation, meets the needs of personalized treatment, improves the stimulation curative effect of the transcranial magnetic stimulation, and expands the near-infrared signal The application range of detection provides a new method and practical tool for neuroscience research, detection and treatment.

The invention discloses a method for eliminating myoelectricity noise in an electroencephalogram signal based on a single channel. The method is characterized by comprising the steps that firstly, a single-channel electroencephalogram signal is decomposed into a plurality of intrinsic mode components through general average empirical mode decomposition; secondly, blind signal separation s conducted on the intrinsic mode components through multi-set canonical correlation analysis, and a plurality of canonical variables are obtained; finally, the canonical variables with the autocorrelation coefficient lower than a certain threshold value are judged to be myoelectricity noise, the myoelectricity noise variables are removed, and reconstruction is conducted to obtain the electroencephalogram signal with the myoelectricity noise removed. According to the method, the purpose of eliminating the myoelectricity noise in the electroencephalogram signal is effectively achieved from the brand new angle of the single channel, and compared with the traditional blind signal separation technology based on the multiple channels, the myoelectricity noise can be better eliminated. The method is suitable for portable and wearable single-channel and few-channel electroencephalogram devices, is also suitable for multi-channel electroencephalogram devices for clinical diagnosis and neuroscience researches, and significant importance is achieved in further researches of the true physiological activities of the human brain.

The invention belongs to the field of cell biology and relates to a method and reagent for the separation and culture of neurons. The method and the reagent are used for solving problems in the prior art, the current in-vitro hippocampal neuron separation and culture methods are improved, and the problem that the proliferation and activity of hippocampal neurons during primary culture can not be maintained is solved. According to the method and the reagent, a relatively mature in-vitro hippocampal neuron culture method is established, the number of obtained nerve cells is sufficient, the growth status is relatively good, and a large number of high-activity hippocampal nerve cells can be separated from mammalian hippocampal tissue, so that the requirements for the primary culture of the hippocampal cells are met, and the demands on experiments of cell biology during neuroscience research can be met.

The invention provides a super-lens microstructure generation method. The method includes the following steps of generating phase maps, calculating phase distribution and generating microstructures. The invention further relates to a micro biphoton microscopy system based on the super-lens. A super-surface lens is introduced into the field of biphoton microscopy, medium numerical aperture focusingis achieved under full field of view, the structure of a microscope is greatly simplified, the weight of the overall equipment is largely reduced, and lighter load animal experiments can be achieved.The reliability of in vivo biphoton microscopy experimental data is improved, and the method has high scientific value for micro biphoton, especially in vivo microscopic imaging; the influence of a backpack type micro microscope system on observed objects (such as mice) is further reduced. According to the system, from simulation design to processing to experiments, a super-surface lens is introduced into the biphoton microscopy imaging system, and a new generation of imaging equipment is provided for brain imaging of living animals. The progress in brain and Neuroscience research is promoted.

The invention belongs to the field of cell biology and relates to a method and reagent for the separation and culture of neurons. The method and the reagent are used for solving problems in the prior art, the current in-vitro hippocampal neuron separation and culture methods are improved, and the problem that the proliferation and activity of hippocampal neurons during primary culture can not be maintained is solved. According to the method and the reagent, a relatively mature in-vitro hippocampal neuron culture method is established, the number of obtained nerve cells is sufficient, the growth status is relatively good, and a large number of high-activity hippocampal nerve cells can be separated from mammalian hippocampal tissue, so that the requirements for the primary culture of the hippocampal cells are met, and the demands on experiments of cell biology during neuroscience research can be met.

The present invention discloses a brain function experimental task stimulation system with real-time feedback and task update functions. The system comprises a computing platform, for detecting and positioning a brain functional area in real time, monitoring image quality of brain function imaging in real time, and detecting and feed backing the current task response level of the brain; the computing platform is provided with a target brain area positioning module, a data quality monitoring module, a task level detection module and a feedback module; the computing platform is also provided with a data acquisition and real-time transmission module, wherein the original function magnetic resonance image is transmitted to the computing platform after acquisition and reconstruction by using a magnetic resonance scanner; and the computing platform is further provided with a task update module, for presenting new experimental task material by comparing and determining to trigger and control the brain function stimulator. According to the system disclosed by the present invention, efficiency of the statistical determination on the active level of the specific brain area is improved, the total time of brain function signal acquisition is shortened, and the system has great practical significance to improve the scanning efficiency of brain function activity and fast positioning of the functional area in clinical patients, and can be applied to the neurological research related to brain functional area detection.

Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) using a new technique, termed multiplexed sensitivity encoding with inherent phase correction, is proposed and implemented to effectively and reliably provide high-resolution segmented DWI and DTI, where shot-to-shot phase variations are inherently corrected, with high quality and SNR yet without relying on reference and navigator echoes. The performance and consistency of the new technique in enabling high-quality DWI and DTI are confirmed experimentally in healthy adult volunteers on 3 Tesla MRI systems. This newly developed technique should be broadly applicable in neuroscience investigations of brain structure and function.

The invention discloses a comprehensive magnetic resonance imaging device. According to the invention, the cerebral function imaging, the MRI perfusion weighted imaging and the magnetic resonance diffusion imaging are united, so that the assessment for the cerebral injury caused by motor neuron disease and Parkinson disease is assisted, a beneficial judging basis is supplied for illness state judgment, and the accuracy rate of disease judgment is increased; an ALS (amyotrophic lateral sclerosis) patient is accompanied with FTD (frontal temporal dementia), so that the detection means, such as cortex thickness, also is beneficial to the disease diagnose and research; functional magnetic resonance imaging (fMRI) and diffusion tensor imaging techniques have strong complementarity; the combination of the functional magnetic resonance imaging and diffusion tensor imaging techniques has a wide application prospect in neurosciences research; unique brain structure and function information can be supplied.

The invention discloses a novel carbon fiber nanocone electrode as well as a preparation method and application thereof, belonging to the field of electrochemistry and material science. The novel carbon fiber nanocone electrode comprises a carbon fiber, an electrode lead and a glass capillary tube, wherein the carbon fiber is connected with the electrode lead through a conductive adhesive; the front part, as long as 50-100 microns, of the carbon fiber is etched to be of a needle shape, and the tip end of the needle-shaped part has the diameter of 100nm-300nm; one end of the glass capillary tube is pulled to form a tip end with the diameter less than or equal to 1micron; the carbon fiber connected with the electrode lead penetrates into the pulled tip of the glass capillary tube, and is exposed out of the tip end of the glass capillary tube; the electrode lead is exposed out of the other end of the glass capillary tube, and the end is sealed by an AB adhesive. According to the invention, the problem that after a nano electrode is insulated, the tip end cannot be exposed easily is solved radically. The carbon fiber nanocone electrode provided by the invention has the advantages of low noise, high sensitivity and high temporal-spatial resolution, and can be applied to real-time detection on neurotransmitter in synaptic cleft in neuroscience research.

The invention belongs to the field of cell biology and relates to a hippocampal neuron separation and primary culture method and reagent. The existing hippocampal neuron separation and primary culture method is improved aiming at the problems of the prior art, and the problem that the proliferation property and the activity of primary culture of the hippocampal neuron cannot be kept is solved. A relatively mature method for culturing hippocampal neurons in vitro is established, the obtained nerve cells are sufficient, the growth condition is good, a number of hippocampal neurons with high activity can be separated from hippocampus of mammals, the requirement of primary hippocampus cell culture is met, and the requirement of cell biology experiments in neuroscience research is met.

The invention discloses an adeno-associated virus with a variant type capsid protein and application thereof. The adeno-associated virus with the variant type capsid protein AAV9-RB is obtained by inserting an amino acid sequence LADQDYTKTA between Q588 and A589 of capsid protein VP1 of wild type AAV9. The adeno-associated virus with the variant type capsid protein AAV9-RB is the first reported virus body that can not only effectively reverse infection from the axon terminal, but also cross the blood-brain barrier to target brain cells. The invention provides better technical support for neuroscience studies and brain disease treatments, with wide application value and prospect.

This invention relates to an interpolation encephalic medicine-feeding canula for nerve scientific research including an integral structure canula and a fixed base, an integral structural airproof cap and a canula filling core, in which, said base is a staged revolving body and screw thread is lathed on the outer wall of a tube part of the staged revolving body, said sealing cap and the core are like a capsule, a rod extending from the inside of the top of the capsule and screwed on the fixed base is set in the inside wall of the capsule as the filling core of the canula to form an integral structure and the outside diameter of the core is a bit smaller than that of the internal diameter, the length of the core is the same with that of the canula and medical stainless steel or polyurethane are materials of the components.

The invention discloses an electroencephalogram signal simulation generating device which mainly comprises an operation unit, a microcontroller unit, an electroencephalogram data input unit, an indication unit, a power supply unit, a signal conversion unit and a signal conditioning output unit. An output end of the operation unit is connected with the microcontroller unit, the microcontroller unitis connected with an input end of the signal conversion unit, the indication unit is connected with the microcontroller unit, the electroencephalogram data input unit is connected with the microcontroller unit, and an output end of the signal conversion unit is connected with an input end of the signal conditioning output unit. The electroencephalogram signal simulation generating device can be used for outputting continuous weak electroencephalogram signals via multiple independent channels; all the multiple independent channels are low in mutual crosstalk and noise; a plurality kinds of man-made noise can be added to the electroencephalogram signals, and requirements for some neuroscience research occasions can be met; electroencephalogram data files which need to be converted can be changed anytime, and operation parameters can be adjusted in real time according to experiment requirements so as to be adapted to different experimental paradigms.

The invention discloses an electrochemical detecting system, which comprises self-reference microelectrode arrays including a plurality of detection sties positioned at the parts to be detected. Reference signals and electrochemical response signals can be acquired simultaneously at the same detection site. An electrochemical surveymeter connected with the self-reference microelectrode arrays is to detect concentrations of chemical substance variation of a plurality of detection sties and output data. The electrochemical detecting system can resolve the problem of consecutively detecting rapid release of cerebral trace neurotransmitters for yonks for researches of neuroscience, and provide a novel research tool and means for researches of neuroscience.

The invention relates to a flexible neural microelectrode based on an oxalis corniculata bionic structure and a preparation method. The structure comprises a flexible electrode substrate, enameled copper wires wrapped by a polyethylene insulating sheath, a PDMS packaging wrapping layer, a silicone sealant at electrode pads and a wire polymerization part, and the like, wherein the connection between the enameled copper wires and the flexible electrode pads is realized through conductive silver paste. Similar to a palm-shaped compound leaf structure composed of three small leaves, the flexible electrode substrate also adopts a similar inverted triangular leaf structure and can be used for synchronous neural signal recording of multi-brain-region cortex. According to the preparation method provided by the invention, the metal recording electrode points and the flexible electrode pads are respectively distributed on different sides of the bottom surface and the top surface through an MEMSpolymer film processing technology, so that vertical connection between the enameled copper wires and the flexible electrode pads is facilitated. The method is simple and easy to implement, the mechanical strength is good, rigid contact with brain tissues can be effectively avoided, and the neuroscience research and application requirements of long-term embedding and collecting of cerebral cortexelectric signals can be met.