Flexible nerve microelectrode based on oxalis corniculata bionic structure and preparation method

Abstract

The invention relates to a flexible neural microelectrode based on an oxalis corniculata bionic structure and a preparation method. The structure comprises a flexible electrode substrate, enameled copper wires wrapped by a polyethylene insulating sheath, a PDMS packaging wrapping layer, a silicone sealant at electrode pads and a wire polymerization part, and the like, wherein the connection between the enameled copper wires and the flexible electrode pads is realized through conductive silver paste. Similar to a palm-shaped compound leaf structure composed of three small leaves, the flexible electrode substrate also adopts a similar inverted triangular leaf structure and can be used for synchronous neural signal recording of multi-brain-region cortex. According to the preparation method provided by the invention, the metal recording electrode points and the flexible electrode pads are respectively distributed on different sides of the bottom surface and the top surface through an MEMSpolymer film processing technology, so that vertical connection between the enameled copper wires and the flexible electrode pads is facilitated. The method is simple and easy to implement, the mechanical strength is good, rigid contact with brain tissues can be effectively avoided, and the neuroscience research and application requirements of long-term embedding and collecting of cerebral cortexelectric signals can be met.

Description

technical field [0001] The invention belongs to the neural microelectrode in the technical field of biomedical engineering, and relates to a flexible neural microelectrode based on the bionic structure of sorrel and a preparation method thereof. Background technique [0002] As one of the emerging flexible neural interfaces, flexible micro-cortical electrodes can collect high-resolution, high-signal-to-noise ratio, and wide-frequency range electrical signals (electrocorticogram, ECoG) on the surface of the cerebral cortex, including information about the activity of cortical neuron populations. , has shown great potential in EEG distribution recording, therapeutic stimulation and brain-computer interface systems. With the rapid development of micro-electromechanical systems (MEMS) technology, flexible micro-cortical electrodes can obtain ultra-small electrode points, and even record the activity of a single neuron on the surface of the cortex. However, most of the existing ...

AI Technical Summary

Problems solved by technology

In the third connection method, the rigid header on the needle seat is inserted vertically into the hole-shaped pad of the flexible electrode. Although the interface of the needle seat connector is vertically upward, the connection between the needle seat connector and the flexible electrode is rigid, which is not conducive to Long-term implantation of electrodes

Although this method also ensures that the Omnetics interface is vertically upward, there is also the problem of rigid connection between the Omnetics interface and the flexible electrode.

[0009] To sum up, most of the pad connection methods of flexible neural microelectrodes used for ECoG EEG signal acquisition reported in the literature currently have flat cables or flexible electrodes that need to be bent, or flexible electrode pads and rigid interfaces. The problem of direct integration and packaging limits the long-term implantation experiments of ECoG flexible neural microelectrodes in animals

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