Implantable multimodal neuromodulation electrode based on photoelectric technology and manufacturing method thereof

Abstract

The invention discloses an implantable multimodal neuromodulation electrode based on a photoelectric technology and a manufacturing method thereof. The implantable multimodal neuromodulation electrode based on the photoelectric technology comprises a base, wherein the base is provided with an electric simulation contact and a light simulation contact; the light simulation contact comprises a light emitting diode; and the light emitting diode comprises an external n electrode, a middle light emitting layer and an internal p electrode. According to the implantable multimodal neuromodulation electrode provided by the invention, electric simulation, light simulation or electric and light combined simulation can be carried out on nerve tissues through adjusting the simulation modes according to different disease cases, so as to reach an optimized treatment effect. The preparation technique provided by the invention is simple, the precision is high, the repeatability is good, and moreover, the unit quantity can be increased through further reducing the size of the simulation unit, thereby improving the resolution, thus, the neuromodulation electrode and the manufacturing method thereof can be widely used for neuroscience research, developing more accurate and more reliable neuromodulation technology in clinical study, researching mechanisms of nervous system diseases such as Parkinson and epilepsy.

Description

technical field [0001] The invention relates to a neuromodulation electrode, in particular to a photoelectric technology-based multimodal implanted neuromodulation electrode and a manufacturing method. Background technique [0002] Neuromodulation refers to the application of stimulation (photostimulation or electrical stimulation) to specific parts of nerve tissue or functional nuclei, so as to achieve the purpose of treating or alleviating nerve-related diseases. It has been successfully applied to the central nervous system such as Parkinson's, epilepsy, and tremor. Disease relief and treatment. [0003] Most of the stimulation electrodes currently used clinically and reported in the literature can only perform a single electrical stimulation mode, and cannot achieve light stimulation or photoelectric combination stimulation. With the development of light-sensing gene regulation technology in recent years, it has been found that light stimulation can stimulate specific n...

AI Technical Summary

Problems solved by technology

These electrodes are basically at the experimental level at present, and cannot be tested in a free living body for a long time to achieve stable optogenetic regulation and electrophysiological recording

In addition, as a stimulating light source, optical fibers can only perform single-point light stimulation, and it is very difficult to achieve multi-point light stimulation and planar light stimulation.

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