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Hydrochloric lorcaserin tablets and preparing method thereof

A technology of lorcaserin hydrochloride and tablets, which is applied in the fields of pill delivery, metabolic diseases, active ingredients of heterocyclic compounds, etc., and can solve problems such as cumbersome preparation process, unfavorable treatment of obese patients, easy to overdose, etc.

Inactive Publication Date: 2016-04-06
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] CN201510071244 discloses a sustained-release capsule of lorcaserin hydrochloride and a preparation method thereof. The sustained-release capsule only needs to be taken once a day, which improves patient compliance, but the preparation process is cumbersome, the process is complicated, and the industrialization is difficult; CN201310673081 Disclosed is a lorcaserin hydrochloride jelly and a preparation method thereof. Although the jelly has a good taste and can increase the compliance of taking it, sugar is added to the prescription composition, which is not conducive to the treatment of obese patients, and it is easy to eat too much, increasing the adverse reaction

Method used

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  • Hydrochloric lorcaserin tablets and preparing method thereof
  • Hydrochloric lorcaserin tablets and preparing method thereof
  • Hydrochloric lorcaserin tablets and preparing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028]

[0029] Preparation process: pass the main drug, microcrystalline cellulose, lactose, povidone and sodium carboxymethyl starch through an 80-mesh sieve, then weigh each material except the lubricant, and deliver the auxiliary materials in the same amount as the main drug in turn. Add and mix evenly; add lubricant and mix evenly, and use powder direct compression technology to compress the tablet, so that the tablet weight is 80-250mg, and the hardness is 20-120N.

Embodiment 2

[0031]

[0032] Preparation process: pass the main drug, microcrystalline cellulose, lactose, povidone and low-substituted hydroxypropyl cellulose through an 80-mesh sieve, then weigh each material except the lubricant, and mix the auxiliary materials with the main drug, etc. Add the amount and mix evenly; add lubricant and mix evenly, and use powder direct compression technology to compress the tablet, so that the tablet weight is 80-250mg, and the hardness is 20-120N.

Embodiment 3

[0034]

[0035] Preparation process: pass the main drug, microcrystalline cellulose, lactose, povidone and crospovidone through an 80-mesh sieve respectively, then weigh each material except the lubricant, and deliver the auxiliary materials in the same amount as the main drug in turn. Add and mix evenly; add lubricant and mix evenly, and use powder direct compression technology to compress the tablet, so that the tablet weight is 80-250mg, and the hardness is 20-120N. Example 4

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Abstract

The invention belongs to the technical field of medicines and particularly relates to hydrochloric lorcaserin tablets and a preparing method thereof. The hydrochloric lorcaserin tablets are prepared from hydrochloric lorcaserin, a thinning agent, a dry binding agent, a disintegrating agent and a lubricating agent. The preparing process of the hydrochloric lorcaserin tablets comprises the step that powder is directly compressed into tablets or the powder is granulated and then compressed into tablets in a dry method, and the production process is simple, controllable, high in operability, short in production cycle, low in production cost and low in industrialization difficulty. The prepared hydrochloric lorcaserin tablets are good in appearance, fast in effect taking and stable in curative effect, the content and the dissolution rate of the hydrochloric lorcaserin tablets are both qualified, and taking compliance of a patient is not affected.

Description

technical field [0001] The invention relates to a lorcaserin hydrochloride tablet for treating obesity and a preparation method thereof. The preparation process of the method is simple and controllable, and the prepared tablet has high dissolution rate, quick onset and stable curative effect, and belongs to the technical field of medicine. Background technique [0002] Obesity and its related metabolic diseases have become a major health issue of common concern all over the world. Increasing evidence shows that obesity has become an important risk factor for hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis, sleep apnea syndrome, respiratory diseases and certain tumors . It can be seen that obesity has become one of the most urgent public health problems to be solved today. [0003] Lorcaserin hydrochloride (trade name ) was developed by Arena Pharmaceuticals Inc. In June 2012, FDA approved lorcaserin for ov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/55A61P3/04
CPCA61K9/2009A61K9/2027A61K9/2054A61K9/2059A61K31/55
Inventor 邵阿丽张庭
Owner BEIJING VENTUREPHARM BIOTECH
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