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A kind of fenbendazole dry emulsion and preparation method thereof

A technology of fenbendazole dry emulsion and fenbendazole, which is applied in the field of medicine, can solve problems such as inconvenient use and poor storage stability, and achieve the effects of convenient portability, high quality stability, and simple preparation process

Inactive Publication Date: 2018-09-18
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of fenbendazole dry emulsion and preparation method thereof, to solve the problems of inconvenient use and poor storage stability of existing similar products

Method used

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  • A kind of fenbendazole dry emulsion and preparation method thereof
  • A kind of fenbendazole dry emulsion and preparation method thereof
  • A kind of fenbendazole dry emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Preparation of the pharmaceutical composition of the present invention

[0019] Take 5 g of fenbendazole, 18825 g of poloxamer, 0.15 g of sodium lauryl sulfate, 20.25 g of sorbitol, 10 g of PEG-6000, 0.5 g of simethicone, and 15 ml of distilled water. The preparation method is to first dissolve sorbitol, poloxamer 188, PEG-6000, sodium lauryl sulfate in boiling water, add simethicone and stir evenly, then add fenbendazole, and put it in a tank mixer Stir in the medium until it becomes granular, take it out, dry it, and pulverize it until it completely passes through a No. 9 sieve (75 μm) to obtain the fenbendazole dry emulsion.

Embodiment 2

[0020] Embodiment 2 Preparation of the pharmaceutical composition of the present invention

[0021] Take 10 g of fenbendazole, 18825 g of poloxamer, 0.15 g of sodium lauryl sulfate, 20.25 g of sorbitol, 10 g of PEG-6000, 0.5 g of simethicone, and 15 ml of distilled water. The preparation method is to first dissolve sorbitol, poloxamer 188, PEG-6000, sodium lauryl sulfate in boiling water, add simethicone and stir evenly, then add fenbendazole, and put it in a tank mixer Stir in the medium until it becomes granular, take it out, dry it, and pulverize it until it completely passes through a No. 9 sieve (75 μm) to obtain the fenbendazole dry emulsion.

Embodiment 3

[0022] Embodiment 3 Preparation of the pharmaceutical composition of the present invention

[0023] Take 20 g of fenbendazole, 18825 g of poloxamer, 0.15 g of sodium lauryl sulfate, 20.25 g of sorbitol, 10 g of PEG-6000, 0.5 g of simethicone, and 15 ml of distilled water. The preparation method is to first dissolve sorbitol, poloxamer 188, PEG-6000, sodium lauryl sulfate in boiling water, add simethicone and stir evenly, then add fenbendazole, and put it in a tank mixer Stir in the medium until it becomes granular, take it out, dry it, and pulverize it until it completely passes through a No. 9 sieve (75 μm) to obtain the fenbendazole dry emulsion.

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PUM

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Abstract

The invention discloses a fenbendazole dry emulsion. The fenbendazole dry emulsion is prepared from, by weight, 5-30 parts of fenbendazole, 20-25 parts of emulgator, 10-25 parts of suspending agent, 20-25 parts of colloid protection agent, 0.05-0.25 part of surface active agent and 0.05-1 part of oil phase. It is indicated through a quality evaluation experiment that the fenbendazole dry emulsion is low in settling velocity, good in physical stability, simple in preparation process, high in bath-to-batch quality stability and convenient to use and carry, the quality requirement of suspensions is met, and good application prospects are achieved.

Description

technical field [0001] The invention relates to a fenbendazole dry emulsion and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Fenbendazole is a benzimidazole anthelmintic widely used clinically. It not only has a high anthelmintic activity against gastrointestinal nematode adults and larvae, but also has a good effect on Dictyocaulus, Fasciola and tapeworms. It has a strong effect of killing insect eggs, and has been widely used in the prevention and treatment of gastrointestinal parasites in sheep, cattle, horses, pigs, dogs, cats and wild animals such as deer, ostriches, camels and other animals. [0003] Fenbendazole is white or off-white powder, odorless, tasteless, slightly soluble in methanol, insoluble in water, soluble in glacial acetic acid. Because fenbendazole has the physical and chemical properties of being insoluble in water and general organic solvents, its clinically commonly used dosage forms are mainly tabl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4184A61K9/14A61K47/10A61K47/26A61K47/20A61P33/10A61P33/00
CPCA61K9/145A61K9/146A61K31/4184
Inventor 杨海涵房春林吴学渊唐华侨李超
Owner CHENGDU QIANKUN VETERINARY PHARMA