Method for preparing colloidal bismuth pectin and method for controlling adhesiveness of medicine composition of colloidal bismuth pectin

A technology of colloidal bismuth pectin and control methods, which is applied in the direction of drug combinations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of insufficient quality control, poor product controllability, and high production costs. problems, to achieve reasonable and controllable content and uniformity, reduce drying time, and reduce measurement errors

Active Publication Date: 2016-04-06
HUNAN WARRANT PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of the traditional production process of colloidal bismuth pectin is that the preparation process is complicated. It is necessary to prepare the pectin product first, and then react with the bismuth salt. It needs drying and sol steps of pectin. The process is complicated and requires equipment and manpower. Many, high production cost
Moreover, the current quality control method of colloidal bismuth pectin pharmaceutical preparations (capsules) is not rigorous enough for the quality control of indicators related to curative effect, resulting in the problem of poor controllability of products with poor curative effect. This application is hereby proposed.

Method used

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  • Method for preparing colloidal bismuth pectin and method for controlling adhesiveness of medicine composition of colloidal bismuth pectin
  • Method for preparing colloidal bismuth pectin and method for controlling adhesiveness of medicine composition of colloidal bismuth pectin
  • Method for preparing colloidal bismuth pectin and method for controlling adhesiveness of medicine composition of colloidal bismuth pectin

Examples

Experimental program
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Effect test

Embodiment 1

[0056] Preparation of colloidal bismuth pectin: (1) Add 166.67g of purified water into the reaction flask, add 29.22g of bismuth nitrate; add about 23.78g of 40% potassium hydroxide solution, adjust the pH to 6-8, and make it hydrolyze completely (i.e. re-test pH constant), filter to get filter cake bismuth hydroxide; then 40.56g of purified water and 17.89g of sorbitol are put into the beaker, after the sorbitol dissolves, filter cake bismuth hydroxide is added and stirred Finally, add about 50 g of 40% potassium hydroxide solution, stir to make it fully dissolve, and obtain a bismuth salt solution for subsequent use;

[0057] (2) Add the bismuth salt solution prepared in step (1) into the reaction bottle, stir, add 49ml of purified water, add pectin soft material at room temperature, after the addition is completed, heat up to about 40°C and stir, keep warm for 0.5 hours, and then add 105g of purified water, temperature controlled at 30-35°C and stirred for 1.5 hours; after ...

Embodiment 2

[0060] The preparation of colloidal bismuth pectin: (1) the preparation of bismuth salt solution: 166.67g purified water is joined in reaction flask, adds bismuth nitrate 29.22g; Add the 40% potassium hydroxide solution of 20g, adjust pH to 6, make it After the hydrolysis is complete (i.e. retest pH is constant), filter to get the filter cake bismuth hydroxide; then 40.56g of purified water and 17.89g of sorbitol are put into the beaker, and then the filter cake bismuth hydroxide is added after the sorbitol dissolves. After stirring, add 48g of 40% potassium hydroxide solution, stir to make it fully dissolved, and obtain a bismuth salt solution for subsequent use;

[0061] (2) Preparation of colloidal bismuth pectin: add the bismuth salt solution prepared above into the reaction bottle, stir, add 49ml of purified water, add pectin soft material at room temperature, after adding, heat up to 45°C and stir, and keep warm for 0.5 hours , then add 105g of purified water, and stir a...

Embodiment 3

[0064] The preparation of colloidal bismuth pectin: (1) the preparation of bismuth salt solution: 166.67g purified water is joined in reaction bottle, adds bismuth nitrate 29.22g; Add the 40% potassium hydroxide solution of 25g, adjust pH to 8, make it After the hydrolysis is complete (i.e. retest pH is constant), filter to get the filter cake bismuth hydroxide; then 40.56g of purified water and 17.89g of sorbitol are put into the beaker, and then the filter cake bismuth hydroxide is added after the sorbitol dissolves. After stirring, add 53 g of 40% potassium hydroxide solution, stir to make it fully dissolve, and obtain a bismuth salt solution for subsequent use;

[0065] (2) Preparation of colloidal bismuth pectin: add the bismuth salt solution prepared above into the reaction bottle, stir, add 49ml of purified water, add pectin soft material at room temperature, after adding, heat up to 45°C and stir, and keep warm for 0.5 hours , then add 105g of purified water, control t...

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Abstract

The invention relates to a method for preparing colloidal bismuth pectin and a method for controlling the adhesiveness of a medicine composition of colloidal bismuth pectin. The method for preparing colloidal bismuth pectin includes the steps that firstly, a bismuth salt solution is prepared; secondly, colloidal bismuth pectin is prepared; thirdly, colloidal bismuth pectin is purified. The method for controlling the adhesiveness of a dry suspension of the medicine composition of colloidal bismuth pectin includes the step of measuring and controlling one or more indexes including the intrinsic viscosity, bismuth ion content uniformity and galacturonic acid content. Colloidal bismuth pectin prepared through the method is reasonable in galacturonic acid content, bismuth ion content, bismuth ion content uniformity and other index contents, high in intrinsic viscosity, and good in clinical effect. The treatment effect of colloidal bismuth pectin is improved, the gastritis cure rate and the Hp eradication rate of colloidal bismuth pectin are greatly increased, and the gastric mucosa protection function of colloidal bismuth pectin is greatly improved.

Description

Technical field: [0001] The application relates to the preparation of colloidal bismuth pectin and a method for controlling the adhesion of the pharmaceutical composition. Background technique: [0002] Colloidal bismuth pectin is an indeterminate compound produced by pectin and bismuth. As a raw material drug, it belongs to gastric mucosal protective drugs. It is characterized in that its molecules are composed of D-galacturonate methyl ester, D-galacturonaldehyde Bismuth bismuth acid and potassium D-galacturonate structural fragments formed polymer compounds and new bismuth salt compounds formed by acid radicals of biomacromolecules. [0003] About the preparation method of colloidal bismuth pectin: the patent document whose application number is CN92114663.9 provides a preparation method of colloidal bismuth pectin medicine, including the preparation of bismuth salt solution, the preparation of pectin soft material, the preparation of colloidal bismuth pectin process of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/06A61K9/14A61K31/732A61P1/04A61P31/04G01N11/06G01N21/78G01N27/42
CPCA61K9/14A61K33/245A61K47/10C08B37/0045G01N11/06G01N21/78G01N27/42
Inventor 黄本东刘庆林张育红肖爱平
Owner HUNAN WARRANT PHARMA
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