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Formula of liver-protecting oral liquid and preparation method of liver-protecting oral liquid

A technology for oral liquid and liver protection, which is applied to the formulation of liver protection oral liquid and the field of preparation thereof, can solve problems such as being vulnerable to trauma, and achieve the effects of reducing liver damage, good curative effect, and small toxic and side effects.

Inactive Publication Date: 2016-04-13
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The liver is an extremely important organ of the human body, responsible for complex body functions, but it is also extremely vulnerable to trauma

Method used

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  • Formula of liver-protecting oral liquid and preparation method of liver-protecting oral liquid
  • Formula of liver-protecting oral liquid and preparation method of liver-protecting oral liquid
  • Formula of liver-protecting oral liquid and preparation method of liver-protecting oral liquid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The invention discloses a preparation method of liver-protecting oral liquid, which is prepared by using the above formula, and the process is as follows:

[0020] Ingredients: Puhuang 5g, Turmeric 5g, Cardamom 5g, Salvia miltiorrhiza 5g, Rhubarb 5g, Capillary 5g, Eupatorium 5g;

[0021] Use water extraction and alcohol precipitation method: heat to boiling according to the prescribed amount, then simmer for 1-1.5 hours, filter out the filtrate, decoct the medicinal residue twice, combine the filtrate and heat to concentrate the filtrate, 2500 rpm, suction filtration for 20 minutes , slowly add 95% ethanol to the filtrate until the alcohol concentration is 60%, and filter to obtain liver-protecting oral liquid.

Embodiment 2

[0023] Experimental purpose and method: To preliminarily evaluate the effect of Hugan Oral Liquid on liver function, 50 young (2-month-old) male rats were randomly divided into 5 groups by establishing an animal model: A sham operation group, B operation group and C low dose In the gavage group, D medium-dose gavage group, and E high-dose gavage group, alanine aminotransferase (ALT), aspartate aminotransferase (AST), liver regeneration rate, malondialdehyde (MDA), proliferating cell nuclear antigen (PCNA) ), liver protein (SOD) levels were analyzed.

[0024] Experimental results: if Figure 1-4 , as shown in Table 1:

[0025] 1. Determination of the content of alanine aminotransferase (ALT) and aspartate aminotransferase (AST)

[0026] The contents of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were determined by automatic biochemical analyzer. The results are shown in Table 1, 24 hours after 70% hepatectomy, the levels of alanine aminotrans...

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Abstract

The invention relates to the field of health foods and medicines, and discloses a formula of liver-protecting oral liquid and a preparation method of the liver-protecting oral liquid. The liver-protecting oral liquid is prepared from pollen typhae, radix curcumae, amomum kravanh, radix salviae miltiorrhizae, radix et rhizoma rhei, capillary artemisia and herba lycopi through reasonable composition, wherein amomum kravanh, radix curcumae and pollen typhae contain alpinetin, and have the effects of effectively protecting liver and reducing liver injury; the liver-protecting oral liquid is prepared based on the combination of previous experiments and clinical applications, and the complete verification of the modern medical science, and in combination with the improvement on the traditional empirical formulae, and has the characteristics of good curative effects and small toxic and side effects; and through the animal experiment, the scientific basis is established for the clinic application of the liver-protecting oral liquid.

Description

technical field [0001] The invention relates to the field of health-care food and medicine, in particular to a formula of liver-protecting oral liquid and a preparation method thereof. Background technique [0002] The liver is an extremely important organ of the human body, responsible for complex body functions, but it is also extremely vulnerable to trauma. Hepatic trauma is most common in abdominal injuries, whether closed or open. At the same time, due to the needs of treatment and the development of living donor liver transplantation, the extensive application of liver lobectomy and segmental resection has gradually increased the proportion of liver trauma caused by surgery. [0003] The liver is also a unique organ with powerful regenerative capabilities. The process of liver regeneration has attracted the attention of researchers for decades. People use it as a standard model of organ regeneration. The study of liver regeneration will not only contribute to the f...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/16A61P29/00
CPCA61K9/0095A61K36/282A61K36/53A61K36/537A61K36/708A61K36/88A61K36/9064A61K36/9066A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 唐博何松青聂容荣王振冉唐芳李扬李铂
Owner GUILIN MEDICAL UNIVERSITY