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Nano-hydroxyapatite-pge2-plga-mss hybrid in-situ gel and its preparation method

A nano-hydroxyapatite, -pge2-plga-mss technology, applied in the digestive system, pharmaceutical formulations, medical preparations with inactive ingredients, etc. Induction ability, increased healing effect, increased stick time effect

Active Publication Date: 2018-11-27
白艳洁 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no report on the hybrid system of hydroxyapatite (HAP) and PGE2-PLGA-MSs

Method used

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  • Nano-hydroxyapatite-pge2-plga-mss hybrid in-situ gel and its preparation method
  • Nano-hydroxyapatite-pge2-plga-mss hybrid in-situ gel and its preparation method
  • Nano-hydroxyapatite-pge2-plga-mss hybrid in-situ gel and its preparation method

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Embodiment Construction

[0017] In a specific embodiment, the preparation and characterization process of the nano-hydroxyapatite-PGE2-PLGA-MSs hybrid insitu gel of the present invention is as follows:

[0018] 1. Preparation of nano-hydroxyapatite-PGE2-PLGA-MSs hybrid in situ gel

[0019] In the experiment, nano-hydroxyapatite and PGE2-PLGA-MSs were doped in a concentrated solution of Poloxamer 407, using the characteristics of reverse temperature-sensitive gelation (liquid fluid at low temperature, and the temperature was increased to 25℃ or more) It is a gel), which can be administered by low-viscosity injection at room temperature and locally transformed into a gel at the injection site to achieve the effect of prolonging the local residence time of the active ingredient in the periodontal.

[0020] Take the formula amount of Lutrol F127, sprinkle it in water in batches, stir slowly until it is evenly dispersed, put it in the refrigerator overnight, add nano-hydroxyapatite, ice bath, and use an ultrasoni...

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Abstract

The invention relates to the field of temperature-sensitive in-situ gel, in particular to nano-hydroxyapatite-PGE2-PLGA-MSs hybridized in-situ gel and a preparation method thereof. The nano-hydroxyapatite-PGE2-PLGA-MSs hybridized in-situ gel is prepared from, by weight, 0.3-1 part of nano-hydroxyapatite, 0.005-0.02 part of PGE2-PLGA-MSs, 0.5-5 parts of Lutrol F127 and 5-15 parts of water. The preparation method comprises the steps that a formula amount of Lutrol F127 is taken to be sprinkled into water by several times, stirring is performed until Lutrol F127 is dispersed to be uniform, the mixture is placed in a refrigerator to be refrigerated for 12-24 hours, nano-hydroxyapatite is added, ice-bath is performed, nano-hydroxyapatite is ultrasonically dispersed to be uniform by adopting a ultrasonic probe, PGE2-PLGA-MSs is added, the mixture is stirred to be uniform, standing is performed, and the nano-hydroxyapatite-PGE2-PLGA-MSs hybridized in-situ gel is formed and then preserved at normal temperature. The in-situ gel is administrated through injection in the low viscosity at the normal temperature, the in-situ gel is converted into gel at part of the injection portion, and therefore the effect of prolonging the residence time of active ingredients at the periodontal part is achieved.

Description

Technical field [0001] The invention relates to the field of temperature-sensitive in-situ gels, in particular to a nano-hydroxyapatite-PGE2-PLGA-MSs hybrid in-situ gel and a preparation method thereof. Background technique [0002] Pen-Chung Chen et al. doped Lidocaine, lactic acid-glycolic acid copolymer (PLGA) microspheres in Poloxamer 407 (English name: Poloxamer, trade name: Pluronic F127 or Lutrol F127) temperature sensitive type In-place gel, referred to as Lutrol F127 in-place gel. After injection to the sciatic nerve, the duration of sensory and motor block is significantly longer than that of lidocaine microspheres alone. This result can be attributed to the slow release and retention effect brought by the high viscosity of the gel. For periodontal injection administration, it is a more serious challenge to extend the local residence time of the preparation and thus exert a better therapeutic effect. [0003] At present, there is no report about the hybrid system of hyd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/5575A61K47/04A61K47/34A61P1/02
CPCA61K9/0019A61K9/0063A61K9/06A61K31/5575A61K47/02A61K47/34
Inventor 白艳洁徐晖白雪涛梁再赋
Owner 白艳洁