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Synthesis method of fluorescent copper nanocluster

A synthetic method and reducing agent technology, applied in the field of biochemistry, can solve the problems of difficult synthesis and easy oxidation, and achieve the effects of good water solubility, high stability, and bright emission of fluorescence

Inactive Publication Date: 2016-04-20
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the synthesis of ultra-small sized copper nanoclusters is very difficult, and even the synthesized copper nanoclusters are easily oxidized in air, the preparation of ultra-small sized and highly stable copper nanoclusters is still a major challenge at present. , therefore, the synthesis of Cu nanoclusters is still at a preliminary stage compared with the synthetic methods of Au and Ag nanoclusters

Method used

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  • Synthesis method of fluorescent copper nanocluster
  • Synthesis method of fluorescent copper nanocluster
  • Synthesis method of fluorescent copper nanocluster

Examples

Experimental program
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Effect test

Embodiment 1～6

[0041] A kind of synthetic method of fluorescent copper nanocluster, described synthetic method is that 5mL concentration is the Cu(NO of 5mM 3 ) 2 The solution was stirred with 5 mL of bovine serum albumin solution with a concentration of 20 mg / mL at 25 °C for 10 min, then added hydroxylamine hydrochloride, adjusted the pH to 12 with NaOH, and stood at 25 °C for 24 h;

[0042] See Table 1 for the volume and concentration values ​​of hydroxylamine hydrochloride in Examples 1-6.

[0043] The volume and concentration of the hydroxylamine hydrochloride of table 1 embodiment 1~6

[0044]

Embodiment 7～13

[0046] A method for synthesizing fluorescent copper nanoclusters, the difference from Example 1 is that the reducing agent is L-ascorbic acid;

[0047] See Table 2 for the volume and concentration values ​​of L-ascorbic acid in Examples 7-13.

[0048] The volume and concentration of the L-ascorbic acid of table 2 embodiment 7~13

[0049]

Embodiment 14～21

[0051]A method for synthesizing fluorescent copper nanoclusters, the difference from Example 1 is that the reducing agent is D-glucose;

[0052] See Table 3 for the volume and concentration of D-glucose in Examples 14-21.

[0053] The volume and concentration of the D-glucose of table 3 embodiment 14~21

[0054]

[0055]

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Abstract

The invention relates to a synthesis method of a fluorescent copper nanocluster, belonging to the technical field of biochemistry. The synthesis method comprises the following steps: uniformly mixing a Cu<2+>-containing solution and a bovine serum albumin solution, adding a reducer, regulating the pH value to 10-13, and standing to react for 6-30 hours, wherein the mole ratio of the Cu<2+>, bovine serum albumin and reducer is 1:4:(1-320), and the reducer is at least one of hydroxylamine hydrochloride, L-ascorbic acid, D-glucose, sodium borohydride and sodium citrate. The synthetic fluorescent copper nanocluster has the advantages of bright emitted fluorescence, small size, high stability, favorable water solubility and the like.

Description

technical field [0001] The invention relates to a method for synthesizing fluorescent copper nanoclusters, belonging to the technical field of biochemistry. Background technique [0002] In recent years, ultrasmall fluorescent metal nanoclusters containing a few to tens of metal atoms, linking atoms and large-sized nanoparticles, have attracted extensive attention due to their size-dependent unique physical and chemical properties. Since the size of metal nanoclusters is similar to the Fermi wavelength of electrons, they exhibit discrete energy levels and molecular-like properties, such as size-tunable electronic transition states and strong fluorescence properties. Metal nanoclusters are considered as novel, potential, and practical nanomaterials with practical applications in many fields, such as: cell imaging, ion sensing, and catalysis. Compared with traditional fluorescent quantum dots, metal nanoclusters have many superior properties, such as: low toxicity, ultra-smal...

Claims

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Application Information

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IPC IPC(8): C09K11/58B82Y40/00
CPCC09K11/58B82Y40/00
Inventor 韩冰雁许杰侯绪芬相荣超李莹彭婷婷于明波
Owner DALIAN UNIV OF TECH
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