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A kind of naringin controlled-release capsule and its preparation method

A technology of glycoside controlled-release capsules and naringin, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., and can solve the problems of slow onset of action, large fluctuations in blood drug concentration, and frequent doses of ordinary sustained-release tablets. and other problems, to achieve the effect of simple technical method, less frequency of taking medicine, and easy access to excipients

Active Publication Date: 2019-03-01
广州中天康顺生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The capsule solves technical problems such as large fluctuations in blood drug concentration, frequent doses, and slow onset of action of ordinary sustained-release tablets caused by the short half-life of ordinary tablets.

Method used

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  • A kind of naringin controlled-release capsule and its preparation method
  • A kind of naringin controlled-release capsule and its preparation method
  • A kind of naringin controlled-release capsule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] Mix the first four of the above materials evenly, granulate with 10% corn starch slurry, dry, add lubricant micropowder silica gel and magnesium stearate after granulation, and press the content of 120 mg of naringin per tablet into tablets.

[0021]

[0022] Mix the first four of the above materials evenly, granulate with 95% ethanol, dry, add lubricant micropowder silica gel and magnesium stearate after granulation, and press 120 mg of naringin per tablet into tablets. The aforementioned two tablets are packed into capsules at a ratio of 1:2. After release measurement, the results show that the release amount of the control capsule is 20% to 30% of the labeled amount in 10 minutes, and the release amount of the released tablet is 35% of the labeled amount in 2 hours, 4 hours, 8 hours, and 12 hours. ~45%, 55~65%, 75~85%, 95% or more, to achieve the purpose of controlled release.

Embodiment 2

[0024]

[0025] Mix the first four of the above-mentioned materials evenly, granulate with 10% corn starch slurry, dry, add lubricant micropowder silica gel and magnesium stearate after granulation, and compress into tablets according to the content of 120 mg of naringin per tablet.

[0026]

[0027] Mix the first four of the above materials evenly, granulate with 95% ethanol, dry, add lubricant micropowder silica gel and magnesium stearate after granulation, and compress into tablets according to the content of 120 mg of naringin per tablet. The aforementioned two tablets are packed into capsules at a ratio of 1:2. After release measurement, the results show that the release amount of the control capsule is 20% to 30% of the labeled amount in 10 minutes, and the release amount of the released tablet is 35% of the labeled amount in 2 hours, 4 hours, 8 hours, and 12 hours. ~45%, 55~65%, 75~85%, 95% or more, to achieve the purpose of controlled release.

Embodiment 3

[0029]

[0030] Mix the first four of the above-mentioned materials evenly, granulate with 10% corn starch slurry, dry, add lubricant micropowder silica gel and magnesium stearate after granulation, and compress into tablets according to the content of 120 mg of naringin per tablet.

[0031]

[0032] Mix the first four of the above materials evenly, granulate with 95% ethanol, dry, add lubricant micropowder silica gel and magnesium stearate after granulation, and press 120 mg per tablet into tablets.

[0033] The aforementioned two tablets are packed into capsules at a ratio of 1:2. After release measurement, the results show that the release amount of the control capsule is 20% to 30% of the labeled amount in 10 minutes, and the release amount of the released tablet is 35% of the labeled amount in 2 hours, 4 hours, 8 hours, and 12 hours. ~45%, 55~65%, 75~85%, 95% or more, to achieve the purpose of controlled release.

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Abstract

The invention discloses a naringin controlled release capsule and a preparation method thereof. Substances contained in the capsule are composed of one part of a quick release drug core and two parts of a slow release drug core; the quick release drug core is mainly prepared from naringin and a quick disintegration agent, and the slow release drug core is prepared from naringin and a hydrophilic gel slow release framework material; each part of the quick release drug core or the slow release drug core contains 1 / 3 the total mass of the naringin. The two types of drug cores are encapsulated according to the ratio of 1: 2, and the capsule is obtained. Compared with the prior art, the capsule is quick in effect onset, the blood concentration is maintained to be effective, stable and durable, and the side effect can be lowered; the production method is simple and applicable to large-scale industrial production.

Description

technical field [0001] The invention relates to a naringin sustained and controlled release capsule and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Naringin is a dihydroflavonoid, mainly found in the peel and pulp of grapefruit, tangerine, and orange of Rutaceae plants. Naringin is also the main active ingredient of Chinese herbal medicine Rhizoma Drynariae, Citrus aurantium, Citrus aurantium, and Tangerine. Naringin has the effects of antitussive, anti-respiratory tract inflammation and inhibition of mucin hypersecretion. Naringin can be used to treat acute and chronic bronchitis. However, the half-life of naringin in the body is short, and patients need to take medication frequently. Such frequent doses are cumbersome to the patient, reduce the compliance of the patient, and easily cause fluctuations in blood drug concentration, which affects the curative effect of the naringin drug. Although slow-release tec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38A61K31/7048A61P11/00
CPCA61K9/0002A61K9/4808A61K31/7048A61K47/36A61K47/38
Inventor 吴忠张昊
Owner 广州中天康顺生物医药有限公司
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