A kind of assay method of stannous content in medicine

A determination method and technology for medicines, which are applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of inaccurate determination of stannous content, cumbersome steps and large errors, and achieve extended retention time, simple steps, and improved accurate determination. Effect

Active Publication Date: 2018-01-19
JIANGSU INST OF NUCLEAR MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is that the assay method of stannous content in the prior art is inaccurate, the error is big and the problems such as step is loaded down with trivial details, and then provides a kind of accurate, the assay method of stannous content in the medicine with simple steps

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  • A kind of assay method of stannous content in medicine
  • A kind of assay method of stannous content in medicine
  • A kind of assay method of stannous content in medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] The assay method of stannous content in the medicine described in this implementation comprises the steps:

[0069] (1) preparation of need testing solution: get need testing, add mobile phase A and mobile phase B solution solution mixed by elution ratio to dissolve and dilute, obtain the sample solution that stannous amount concentration is 0.01mg / mL, i.e. have to;

[0070] (2) Preparation of reference substance solution: get tin protochloride (SnCl 2 2H 2 (2) 100mg, accurately weighed, placed in a 10mL measuring bottle, added 0.05mol / L dilute hydrochloric acid to dissolve and diluted to the scale, to obtain a stannous chloride solution, and accurately measure 0.05mL of the stannous chloride solution and place it in 10mL In the measuring bottle, add the mobile phase A and mobile phase B solution mixed according to the elution ratio and dilute to the mark to obtain;

[0071] Chromatographic conditions and system suitability test: According to high performance liquid ...

Embodiment 2

[0074] The assay method of stannous content in the medicine described in this implementation comprises the steps:

[0075] (1) Preparation of need testing solution: get need testing, add mobile phase A and mobile phase B solution mixed by elution ratio to dissolve and dilute, obtain the sample solution that stannous amount concentration is 0.5mg / mL, obtain final product ;

[0076] (2) Preparation of reference substance solution: get tin protochloride (SnCl 2 2H 2(2) 100mg, accurately weighed, placed in a 10mL measuring bottle, added 0.03mol / L dilute hydrochloric acid to dissolve and diluted to the mark, to obtain a stannous chloride solution, and accurately measure 0.15mL of the stannous chloride solution and place it in 10mL In the measuring bottle, add the mobile phase A and mobile phase B solution mixed according to the elution ratio and dilute to the mark to obtain;

[0077] Chromatographic conditions and system suitability test: According to high performance liquid chr...

Embodiment 3

[0080] The assay method of stannous content in the medicine described in this implementation comprises the steps:

[0081] (1) preparation of need testing solution: get need testing, add mobile phase A and mobile phase B solution mixed by elution ratio to dissolve and dilute, obtain the sample solution that stannous amount concentration is 0.01mg / mL, obtain final product ;

[0082] (2) Preparation of reference substance solution: get tin protochloride (SnCl 2 2H 2 (2) 100mg, accurately weighed, placed in a 10mL measuring bottle, added 0.05mol / L dilute hydrochloric acid to dissolve and diluted to the mark, to obtain a tin protochloride solution, accurately measure 0.1 mL of the stannous chloride solution and place it in 10 mL In the measuring bottle, add the mobile phase A and mobile phase B solution mixed according to the elution ratio and dilute to the mark to obtain;

[0083] Chromatographic conditions and system suitability test: According to high performance liquid chro...

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Abstract

The invention provides a determination method of tin content in drugs. The determination method includes the following steps: (1) preparing a test solution; (2) preparing a reference solution; (3) performing chromatographic condition and system suitability test: adopting high performance liquid chromatography, taking octadecylsilane chemically bonded silica as a filling agent, phosphate solution 5-8g / L in concentration as a mobile phase A containing 2.8g / L-3.5g / L ion pair reagent and 0.7g / L-1.1g / L metal complexing agent and chromatographic pure methanol as a mobile phase B, performing elution according to the volume ratio of the mobile phase A to the mobile phase B being 78-92:22-8; controlling the flow velocity of the mobile phase to be 0.8mL / min-1.2mL / min; controlling the column temperature to be 20-30 DEG C; controlling detection wavelength to be 248nm-252nm; measuring and calculating results. By the determination method, the problem that the tin content determination method in the prior art is inaccurate, complicated in steps and the like is solved.

Description

technical field [0001] The invention belongs to the field of determination of metal element content, in particular to a method for determination of stannous content in medicines. Background technique [0002] Tin is a kind of bluish white luster metal element with low melting point, which is divalent or tetravalent in the compound and will not be oxidized by air. Tin is one of the indispensable trace elements in the human body. Its main physiological function is anti-tumor, and excessive tin intake in the human body will cause damage to the central nervous system. Among them, stannous chloride is often used as a reducing agent, such as radioactive technetium[ 99m Tc] labeled freeze-dried drugs generally include labeled ligands, reducing agents, auxiliary materials, etc., which are used to prepare radioactive technetium [ 99m Tc] labeled injection, when in use, freshly rinsed high technetium [ 99m Tc] acid salt injection is added to the freeze-dried product, +7-valent high...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 汪洋陈志明吴二明王刚黄荷云
Owner JIANGSU INST OF NUCLEAR MEDICINE
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