A capsule preparation for treating insomnia with reverse pharmacological functions

A reverse pharmacological and functional technology, applied in the field of drugs for the treatment of insomnia, can solve problems affecting normal work and achieve the effect of promoting sleep

Active Publication Date: 2018-06-29
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current drugs used to treat insomnia, usually due to the existence of side effects, people will still be in a drowsy state after getting up in the morning, which will inevitably affect people's normal work during the day

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] 1. Weigh the raw materials (grams) according to the following ratio:

[0011] (1) Diazepam 5, Flumazenil 25, Caffeine 30, Ethylcellulose 100, Starch 30, Polyvinylpyrrolidone 20 and Magnesium Stearate 3;

[0012] (2) Diazepam 4, Flumazenil 27, Caffeine 25, Ethylcellulose 125, Starch 25, Polyvinylpyrrolidone 22 and Magnesium Stearate 2;

[0013] (3) Diazepam 6, flumazenil 22, caffeine 35, ethyl cellulose 150, starch 35, polyvinylpyrrolidone 18 and magnesium stearate 4.

[0014] 2. Preparation method

[0015] Weigh the raw materials respectively according to the above proportions, mix diazepam and starch evenly, add distilled water to granulate, dry and mix with magnesium stearate for granulation, then mix flumazenil and caffeine with ethyl cellulose The microcapsules are prepared by emulsified solvent diffusion method, and then mixed with stabilized granules and packed into capsules to obtain a capsule preparation for treating insomnia with reverse pharmacological funct...

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PUM

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Abstract

The invention discloses a capsule preparation having a reverse pharmacological function and used for treating insomnia. The capsule preparation is prepared from, by weight, 4-6 parts of diazepam, 22-27 parts of flumazenil, 25-35 parts of caffeine, 100-150 parts of ethyl cellulose, 25-35 parts of starch, 18-22 parts of polyvinylpyrrolidone and 2-4 parts of magnesium stearate. The specific preparation process comprises the steps of uniformly mixing the diazepam and the starch, then adding distilled water to perform granulation, drying the mixture, then mixing the mixture and the magnesium stearate for size stabilization, using the ethyl cellulose as a capsule wall material for the flumazenil and the caffeine, adopting an emulsified solvent diffusion method to prepare micro-capsules, then mixing the micro-capsules with prepared diazepam granules, and charging the mixture into the capsules in a split mode to obtain the capsule preparation having the reverse pharmacological function and used for treating the insomnia. The capsule preparation can play the effect of promoting sleep at night and cannot affect the normal work of a user in the daytime.

Description

technical field [0001] The invention belongs to the technical field of drugs for treating insomnia, and in particular relates to a capsule preparation for treating insomnia with reverse pharmacological functions. Background technique [0002] Insomnia is mainly manifested as difficulty falling asleep or waking up early, often accompanied by not deep sleep and dreaminess. Insomnia is a common sleep disorder. Insomnia is often caused by mental and physical factors. Along with the continuous acceleration of modern social life rhythm, the incidence of insomnia is getting higher and higher, and insomnia has become a serious factor restricting the life of modern people. Current medicines for treating insomnia usually still cause people to be in a drowsy state after getting up in the morning due to the existence of side effects, which will inevitably affect people's normal work during the day. Contents of the invention [0003] The technical problem solved by the invention is ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38A61K31/5517A61P25/20A61K31/5513A61K31/522
CPCA61K9/1652A61K9/5047A61K31/522A61K31/5513A61K31/5517A61K2300/00
Inventor 董亭方裴素娟郗玉玲张卫国秦肖菲张永香王业民
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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