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Dihydroartemisinic acid synthesis technology

A technology of dihydroartemisinic acid and synthesis process, applied in the direction of ozone oxidation to prepare carboxylic acid, organic chemistry, etc., can solve the problems of low production efficiency, unsuitable for large-scale production, complicated production process, etc., to improve work efficiency and improve Single-pass conversion rate and product yield, the effect of overcoming many processes

Inactive Publication Date: 2016-06-01
QINGDAO SHOUTAI AGRI SCI & TECH CO LTD
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Problems solved by technology

In the current synthesis process of dihydroartemisinic acid, the technical process is not easy to implement, the resulting dihydroartemisinic acid product has low purity, the single-pass conversion rate of reactants is low, the production process is complicated, the production efficiency is low and the cost is high, so it is not necessary suitable for mass production

Method used

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Embodiment

[0012] The dihydroartemisinic acid synthesis technique of the present embodiment comprises the following steps:

[0013] (1) Artemisinic acid is dissolved in organic solvent;

[0014] (2) Add hydrazine hydrate and a catalytic amount of transition metal compound, and adjust the reaction temperature to 65°C;

[0015] (3) adding hydrogen peroxide dropwise to the reaction solution, so that the artemisinic acid is reduced to dihydroartemisinic acid by diimine produced in situ;

[0016] (4) After extraction and drying, dihydroartemisinic acid is obtained.

[0017] The synthesis process of dihydroartemisinic acid does not require cumbersome post-reaction treatment, the process is simple and feasible, and it is environmentally friendly and pollution-free, the process flow is easy to implement, and the industrial production of the product is realized.

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Abstract

The invention discloses a dihydroartemisinic acid synthesis technology. The technology comprises dissolving dihydroartemisinic acid in an organic solvent, adding hydrazine hydrate and a catalytic amount of a transition metal compound into the solution, adjusting a reaction temperature in a range of 65-100 DEG C, dropwisely adding hydrogen peroxide into the reaction solution so that the arteannuic acid is reduced into dihydroartemisinic acid through diimine produced in situ, and carrying out extraction and drying to obtain dihydroartemisinic acid. The technology has short synthesis reaction time and a high dihydroartemisinic acid yield.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a synthesis process of dihydroartemisinic acid. Background technique [0002] The synthesis process of 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone at least includes processes such as thermoregulation reaction, extraction, and drying. In the current synthesis process of dihydroartemisinic acid, the technical process is not easy to implement, the resulting dihydroartemisinic acid product has low purity, the single-pass conversion rate of reactants is low, the production process is complicated, the production efficiency is low and the cost is high, so it is not necessary Suitable for mass production. Contents of the invention [0003] In order to overcome the above-mentioned technical problems existing in the prior art field, the object of the present invention is to provide a dihydroartemisinic acid synthesis process. The present invention not only has...

Claims

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Application Information

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IPC IPC(8): C07C57/26C07C51/36
Inventor 张晶
Owner QINGDAO SHOUTAI AGRI SCI & TECH CO LTD
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