Dihydroartemisinic acid synthesis technology

A technology of dihydroartemisinic acid and synthesis process, applied in the direction of ozone oxidation to prepare carboxylic acid, organic chemistry, etc., can solve the problems of low production efficiency, unsuitable for large-scale production, complicated production process, etc., to improve work efficiency and improve Single-pass conversion rate and product yield, the effect of overcoming many processes

Inactive Publication Date: 2016-06-01
QINGDAO SHOUTAI AGRI SCI & TECH CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current synthesis process of dihydroartemisinic acid, the technical process is not easy to implement, the resulting dihydroartemisinic acid product has low purity, the single-pas

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0012] The dihydroartemisinic acid synthesis technique of the present embodiment comprises the following steps:

[0013] (1) Artemisinic acid is dissolved in organic solvent;

[0014] (2) Add hydrazine hydrate and a catalytic amount of transition metal compound, and adjust the reaction temperature to 65°C;

[0015] (3) adding hydrogen peroxide dropwise to the reaction solution, so that the artemisinic acid is reduced to dihydroartemisinic acid by diimine produced in situ;

[0016] (4) After extraction and drying, dihydroartemisinic acid is obtained.

[0017] The synthesis process of dihydroartemisinic acid does not require cumbersome post-reaction treatment, the process is simple and feasible, and it is environmentally friendly and pollution-free, the process flow is easy to implement, and the industrial production of the product is realized.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a dihydroartemisinic acid synthesis technology. The technology comprises dissolving dihydroartemisinic acid in an organic solvent, adding hydrazine hydrate and a catalytic amount of a transition metal compound into the solution, adjusting a reaction temperature in a range of 65-100 DEG C, dropwisely adding hydrogen peroxide into the reaction solution so that the arteannuic acid is reduced into dihydroartemisinic acid through diimine produced in situ, and carrying out extraction and drying to obtain dihydroartemisinic acid. The technology has short synthesis reaction time and a high dihydroartemisinic acid yield.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a synthesis process of dihydroartemisinic acid. Background technique [0002] The synthesis process of 2-hydroxy-2-methyl-1-phenyl-1-propyl ketone at least includes processes such as thermoregulation reaction, extraction, and drying. In the current synthesis process of dihydroartemisinic acid, the technical process is not easy to implement, the resulting dihydroartemisinic acid product has low purity, the single-pass conversion rate of reactants is low, the production process is complicated, the production efficiency is low and the cost is high, so it is not necessary Suitable for mass production. Contents of the invention [0003] In order to overcome the above-mentioned technical problems existing in the prior art field, the object of the present invention is to provide a dihydroartemisinic acid synthesis process. The present invention not only has...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C57/26C07C51/36
Inventor 张晶
Owner QINGDAO SHOUTAI AGRI SCI & TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap