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Alkalescent sodium chloride and dextrose injection medicinal composition

A technology of glucose sodium chloride and composition, which is applied in the direction of drug combination, active ingredient of alkali/alkaline earth metal chloride, drug delivery, etc., and can solve problems such as irritation, large gap, poor pH balance ability, etc.

Inactive Publication Date: 2016-06-08
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] It is precisely because the pH value of Glucose Sodium Potassium Chloride Injection is acidic, there are some problems in use. First, the body fluids of normal people are basically weakly alkaline, for example, the pH value of blood is 7.35-7.45, and the pH value of interstitial fluid is 7.0. ~7.5, the pH value of the cell fluid is 7.20~7.45, and the peritoneal dialysis fluid with a pH value of ≤7 has a large gap with the body fluid, which will cause greater irritation and damage to the body. It is often used, and children have poor ability to balance the PH value of body fluids, especially if they use a large amount of acidic glucose sodium chloride potassium injection, they are more likely to have problems.

Method used

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  • Alkalescent sodium chloride and dextrose injection medicinal composition
  • Alkalescent sodium chloride and dextrose injection medicinal composition
  • Alkalescent sodium chloride and dextrose injection medicinal composition

Examples

Experimental program
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Effect test

Embodiment 1

[0035]

[0036]Preparation method: Dissolve the prescribed amount of glucose, sodium chloride, and potassium chloride in 700ml of water for injection, adjust the pH to the required level with 0.1mol / L of PH regulator in the aqueous solution for injection, then add 0.1-1% medicinal charcoal and stir evenly. Leave it for 10-20 minutes, filter through a terminal of 0.22 μm, dilute to 1000 ml with the remaining water for injection, filter through a terminal of 0.22 μm, and then potting. Use nitrogen protection during preparation and potting. Sterilize at 115°C for 30 minutes. Use nitrogen protection during preparation and potting.

Embodiment 2

[0038]

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0041]

[0042]

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PUM

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Abstract

The invention relates to an alkalescent sodium chloride and dextrose injection medicinal composition. The alkalescent sodium chloride and dextrose injection medicinal composition contains glucose, sodium chloride, potassium chloride, tris(hydroxymethyl)aminoethane and water.

Description

technical field [0001] The invention relates to a weakly alkaline glucose sodium chloride injection composition, which contains glucose, sodium chloride, potassium chloride, trishydroxymethylaminomethane and water. Background technique [0002] Glucose is one of the main energy sources of the human body. Sodium and chlorine are important electrolytes in the body, which play a very important role in maintaining the normal volume and osmotic pressure of blood and extracellular fluid in the human body. Potassium is the main cation in cells, and the normal concentration and concentration difference of potassium ions inside and outside cells are closely related to some functions of cells, such as carbohydrate metabolism, glycogen storage and protein metabolism, excitability and conductivity etc. [0003] In clinical practice, in order to replenish body fluids, maintain body electrolyte balance and supply carbohydrates, glucose sodium chloride potassium injection is often used. ...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61K47/18A61P3/12A61P3/08A61K31/7004
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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