A method of extracting dibutyl phthalate from common buried rubber and applications of the dibutyl phthalate

A technology of dibutyl phthalate and ethyl acetate, which is applied in the application of anti-lung cancer drugs and the field of preparation of anti-lung cancer, can solve the problems of little research on small molecule pharmacodynamics and little research on small molecular compounds, and achieve practical High performance, stable properties, and low reagent consumption
CN105693518AActive Publication Date: 2016-06-22TIANJIN YAOYU BIOLOGICAL TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN YAOYU BIOLOGICAL TECH
Publication Date
2016-06-22

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Abstract

The invention provides a method for extracting dibutyl phthalate from triangular prisms, which comprises the following steps: take triangular prisms and add ethyl acetate to extract after superfine grinding, precipitate after centrifugation and add 95% ethanol for extraction, and centrifuge to extract dibutyl phthalate. Concentrate and dry the supernatant; add 80% methanol-water solution to sonicate to 15-50mg / ml, and 18 Reversed-phase silica gel chromatography column for liquid chromatography separation, using A pure water, B methanol binary mobile phase, the elution method is 20% methanol-water elution 5min, 40% methanol-water elution 7min, 80% methanol-water elution Water was eluted for 13 minutes, 100% methanol was eluted for 5 minutes, and the eluate was collected for 21-22 minutes according to the ultraviolet absorption spectrum, concentrated and vacuum freeze-dried to obtain dibutyl phthalate with a purity of more than 99%. The method has the advantages of stable separation method, high repeatability, large preparation amount, simple and time-saving operation.
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Description

technical field

[0001] The present invention relates to the technical field of traditional Chinese medicine extraction, in particular to a method for extracting dibutyl phthalate monomer compound from trigonum, and the application of the dibutyl phthalate in the preparation of anti-liver cancer and anti-lung cancer drugs . Background technique

[0002] Dibutyl phthalate is a small molecular compound usually obtained by organic synthesis. It is a colorless, transparent or slightly yellow oily liquid, and its molecular formula is C 16 h 22 o 4 , the molecular weight is 278.35, and its skeleton is composed of a structure similar to a four-membered ring. The structural formula is as follows:

[0003]

[0004] Today's applications of dibutyl phthalate mainly include the following aspects:

[0005] 1. Used as gas chromatography stationary liquid and solvent;

[0006] 2. Used as a plasticizer, mainly used as a plasticizer for nitrocellulose, cellulose acetate, polyvinyl chl...

Claims

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