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Bionic dynamic mouse stomach-duodenum digestive system simulation device and simulation experiment method

A duodenum and digestive system technology, which is applied in the field of bionic dynamic rat stomach-duodenal digestive system simulation device, can solve the problems of inconvenient disassembly and cleaning, complex structure, and inability to effectively verify the effectiveness and scientificity of the system , to achieve the effect of enhancing the authenticity of

Active Publication Date: 2016-06-22
XIAODONGYIJIAN SUZHOU INSTR & EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of them have the details of the shape and physiological structure of the real stomach or intestine (size, folds of the inner wall of the stomach, etc.), cannot reproduce the distribution of food in the real stomach and the order of digestion and emptying, and lack the knowledge of the stomach or intestinal wall. Efficient simulation of peristaltic contractions
In addition, these systems are complex in structure, high in cost, and inconvenient to disassemble and clean; due to ethical restrictions, it is impossible to easily obtain physiological parameters related to the human gastrointestinal tract, which makes it impossible to effectively verify the validity and scientific nature of the above systems

Method used

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  • Bionic dynamic mouse stomach-duodenum digestive system simulation device and simulation experiment method
  • Bionic dynamic mouse stomach-duodenum digestive system simulation device and simulation experiment method

Examples

Experimental program
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Effect test

Embodiment 1

[0087] The dynamic bionic mouse gastroduodenal digestive system device as shown in the figure is used to simulate the mixing, grinding and digestion process of raw rice particles in the rat stomach, and the pH, particle size distribution and digestion products of the stomach contents are detected— The concentration of maltose was compared with the results of in vivo live mouse experiments to verify the effectiveness of the device. The specific operation process is as follows:

[0088] (1) According to the device of the present invention, the device of the present invention is assembled completely;

[0089] (2) Adjust the room temperature in the insulation box: turn on the heating lamp and digital display thermostat in the insulation box, and turn off the heating lamp when the temperature in the insulation box is maintained at 37°C;

[0090] (3) Gastric juice filling: take a gastric juice tube, fill it with gastric juice, and then connect one end of the gastric juice tube to t...

Embodiment 2

[0100] The dynamic bionic rat stomach-duodenum digestive system device as shown in the figure was used to simulate the mixing, grinding, digestion and emptying process of wheat starch granules containing 10% pectin in the stomach and duodenum of rats. Detect the pH, maltose concentration, starch hydrolysis rate, gastric emptying rate, rheological properties and microstructure of gastric content, and compare with the results of in vivo live mouse experiments and related literature, so as to further verify the effectiveness of the device, and To investigate the effect of soluble dietary fiber pectin on the digestion and emptying of wheat starch in the gastrointestinal tract. The specific operation process is as follows:

[0101] (1) According to the device of the present invention, the device of the present invention is assembled completely;

[0102] (2) Adjust the room temperature in the insulation box: turn on the heating lamp and digital display thermostat in the insulation ...

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Abstract

The invention relates to a bionic dynamic mouse stomach-duodenum digestive system simulation device and simulation experiment method. The bionic dynamic mouse stomach-duodenum digestive system simulation device includes a stomach digestive system, a duodenum digestive system, a feeding-emptying device and a heat preservation box, the feeding-emptying device conveys gastric juice towards the stomach digestive system, and conveys bile and pancreatic juice towards the duodenum digestive system, and the stomach digestive system and the duodenum digestive system are communicated with each other. The bionic dynamic mouse stomach-duodenum digestive system simulation experiment method includes the steps of: (1) adjusting temperature in the heat preservation box; (2) filling gastric juice, pancreatic juice and bile; (3) preparing a food sample; (4) injecting gastric juice to a bionic mouse stomach model; (5) injecting the food sample to the bionic mouse stomach model; (6) simulating a digestion process; and (7) recording the digestion process according to periods of time. The bionic dynamic mouse stomach-duodenum digestive system simulation experiment method has a real simulation result, the digestion process is extremely similar to a digestion process of a living mouse, and thus the method has very good application value.

Description

technical field [0001] The invention relates to a bionic dynamic mouse gastroduodenal digestive system simulation device and a simulation experiment method. The digestive system simulation device can be used for mixing, mixing, Grinding, digestion and emptying process. Background technique [0002] At present, before any new functional food or drug is put into the market and trusted and accepted by consumers and patients, it must undergo strict experiments and evaluations in terms of nutritional value, toxicology, and pharmacology. To evaluate the release rate and utilization rate of its nutrients and effective active ingredients in the gastrointestinal tract, it is first necessary to understand their digestion and emptying process in the stomach, and understand their nutrient delivery process in the body, so as to improve the food and drug. Processing methods or construction of new functional foods can effectively improve the digestion and absorption of nutrients and the u...

Claims

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Application Information

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IPC IPC(8): G09B23/36G09B9/00
CPCG09B9/00G09B23/36
Inventor 陈晓东伍鹏陈利丁廖振锴
Owner XIAODONGYIJIAN SUZHOU INSTR & EQUIP CO LTD