Hand-held micro-raman based detection instrument and method of detection

Abstract

A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 893,095, filed August 7, 2013. The entire disclosure of the above application is incorporated herein by reference. technical field [0003] The present disclosure relates to methods and devices for the rapid detection and identification of protein-based compounds including bacteria, viruses, drugs or tissue abnormalities, and more particularly to portable spectrometers based on Raman spectroscopy, It is suitable for inspecting mucosal surfaces (nostrils, mouth, ears) for protein-based compounds including MRSA or other pathogens, interrogating wound sites and / or inspecting potentially contaminated objects or surfaces. The device may be suitable for testing tissue samples, feces, urine, serum or secretions. Background technique [0004] This section provides background information related to the present disclosure which is not necessarily prior ar...

AI Technical Summary

Problems solved by technology

Although faster, this technique still takes hours and is sent to the lab

Additionally, commercially available molecular methods (used for screening) cannot detect the mecA variant of MRSA

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