Hand-held micro-raman based detection instrument and method of detection

A detection instrument and a hand-held technology, applied in the field of micro-Raman-based hand-held detection instruments and detection, can solve the problems of cost and inability to detect mecA variants, etc.

Active Publication Date: 2016-06-29
SERAPH BIOSCI +1
View PDF11 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although faster, this technique still takes hours and is sent to the lab
Additionally, commercially available molecular methods (used for screening) cannot detect the mecA variant of MRSA

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hand-held micro-raman based detection instrument and method of detection
  • Hand-held micro-raman based detection instrument and method of detection
  • Hand-held micro-raman based detection instrument and method of detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0041] The feasibility of using a laboratory Raman spectrometer to evaluate Raman spectra of various protein-based compounds comprising numerous pathogens was demonstrated through preliminary studies described in more detail below. For these studies, the following pathogens were evaluated in the absence of background interference:

[0042] ●MSSA-1S: Staphylococcus aureus subsp.aureus (Staphylococcus aureus subsp.aureus) ( 6538 TM );

[0043] ●MSSA-2S: Staphylococcus aureus subsp. aureus ( BAA1721 TM );

[0044] ●MRSA-1R: Staphylococcus aureus ( BAA1683 TM );

[0045] ●MRSA-2R: Staphylococcus aureus subsp. aureus ( 700787 TM );

[0046] ●Corynebacterium sp. ( 6931 TM );

[0047] ●Staphylococcus epidermidis ( 12228 TM );

[0048] ● Influenza virus APR8 / 34 (H1N1);

[0049] Influenza virus A / WSN / 32 (H1N1); and

[0050] • Influenza virus A / Udorn / 72 (H2N3).

[0051] For additional pathogens (e.g., Bacillus subtilis, E. coli K99, E. coli O111, E. coli O157, E...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 893,095, filed August 7, 2013. The entire disclosure of the above application is incorporated herein by reference. technical field [0003] The present disclosure relates to methods and devices for the rapid detection and identification of protein-based compounds including bacteria, viruses, drugs or tissue abnormalities, and more particularly to portable spectrometers based on Raman spectroscopy, It is suitable for inspecting mucosal surfaces (nostrils, mouth, ears) for protein-based compounds including MRSA or other pathogens, interrogating wound sites and / or inspecting potentially contaminated objects or surfaces. The device may be suitable for testing tissue samples, feces, urine, serum or secretions. Background technique [0004] This section provides background information related to the present disclosure which is not necessarily prior ar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01J3/44
CPCG01J3/44G01J3/0291G01J3/0264G01J3/0208G01J3/0272G01N21/65G01N2201/0221A61B5/6846A61B5/0075A61B5/445A61B5/6815A61B5/6819A61B5/682G01J2003/1213G01J3/18G01J3/2823G01J2003/2826C12Q1/04C12Q1/14G01J3/4406G01J3/4412G01N2333/11G01N2333/31G01N2333/34
Inventor 格雷戈里·威廉·奥纳查尔斯·尚利米歇尔·布鲁萨托里塔拉·图梅戴维·桑特
Owner SERAPH BIOSCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap