Application of donkey-hide gelatins to preparation of medicament or healthcare product for treating respiratory injury caused by fine air particulate matters

A fine particulate matter and respiratory system technology, which is applied in the field of new medical applications of donkey-hide gelatin, can solve the problems of respiratory system damage protection and achieve the effect of preventing respiratory system damage

Inactive Publication Date: 2016-07-06
SHAN DONG DONG E E JIAO
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, whether donkey-hide gelatin has a protective effect on respiratory system damage caused by fine air particles has not been reported at home and abroad.

Method used

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  • Application of donkey-hide gelatins to preparation of medicament or healthcare product for treating respiratory injury caused by fine air particulate matters
  • Application of donkey-hide gelatins to preparation of medicament or healthcare product for treating respiratory injury caused by fine air particulate matters
  • Application of donkey-hide gelatins to preparation of medicament or healthcare product for treating respiratory injury caused by fine air particulate matters

Examples

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Effect test

experiment example 1

[0033] Experimental Example 1 Study on the Protective Effect of Ejiao on Rat Respiratory System Injury Induced by Air Fine Particles

[0034] 1. Experimental method

[0035] 1.1 Raising standards and grouping of experimental animals

[0036]The laboratory animal facility continues to maintain barrier environmental standards. The control range of the main environmental indicators: room temperature 20-26 ℃, daily temperature difference ≤ 4 ℃. The relative humidity is 40-70%. The minimum number of air changes is 15 times / hour, light illumination: dark = 12h: 12h. The animals are kept in polypropylene rat group breeding boxes, the cage specifications are: 545*395*200mm3, 3 to 5 rats per box, and the feeding space conforms to the minimum space required for experimental animals in the national standard GB14925-2010 of the People's Republic of China Provisions. All animals were kept and managed by trained and qualified personnel. Bedding and cages were changed once a week. Rat...

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Abstract

The invention discloses application of donkey-hide gelatins to preparation of a medicament or healthcare product for treating respiratory injury caused by fine air particulate matters, and belongs to the field of novel medicinal uses of donkey-hide gelatins. SD rats continuously inhale the fine air particulate matters for 8 weeks, and are given by gavage with different dosages of donkey-hide gelatin solutions for medicinal intervention at the same time of contamination, researches on an injury mechanism caused by toxicity and a protection mechanism of the donkey-hide gelatins for respiratory injury caused by the fine air particulate patterns are made from weights, organ coefficients and pulmonary functions in combination with the aspects of the hematology, blood biochemical index measurement, respiratory functions, histopathological examination, oxidative damage and the like, and experimental results show that the donkey-hide gelatins can be used for effectively reducing the content of malondialdehyde and the number of pulmonary alveolar phagocytes and increasing the content of glutathione peroxidase, have an exact improvement effect on rat pulmonary function and pulmonary pathological changes caused by the fine air particulate matters and can be applied to preparation of the medicament or healthcare product for treating respiratory injury caused by the fine air particulate matters.

Description

technical field [0001] The invention relates to new medical uses of donkey-hide gelatin, in particular to the use of donkey-hide gelatin in the preparation of medicines or health products for preventing respiratory system damage caused by air fine particles, and belongs to the field of new medical uses of donkey-hide gelatin. Background technique [0002] At present, the problem of air pollution in China is becoming more and more serious, and moderate and severe air pollution problems occur from time to time in many areas. Fine particulate matter (PM2.5) has become the main environmental pollution component that endangers human health in recent years. Due to the small aerodynamic particle size and large specific surface area of ​​PM2.5 fine particles, it is easy to carry a large amount of toxic and harmful substances such as industrial waste gas, volatile chemicals, and motor vehicle exhaust, and enter the human lungs through the respiratory tract through the filtering effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/36A61P11/00A23L33/10A23L2/38
CPCA23L2/38A61K35/36A23V2002/00A23V2200/314
Inventor 周祥山顾建军王爱平史兆松
Owner SHAN DONG DONG E E JIAO
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