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Method for preparing traditional-Chinese-medicine oral liquid for treating child hyperactivity

A technology of traditional Chinese medicine oral liquid and children's ADHD, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc. There are no effective removal methods for clarity and protein, etc., to achieve the effect of retaining the active ingredients of the drug, reducing secondary pollution, and retaining the active ingredients

Inactive Publication Date: 2016-07-06
LIAONING ORIENTAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with the advancement of technology and the development of society, there are some defects in this variety in practice, which are difficult to control clinical quality, unstable content, gradually darker color, serious loss of active ingredients, incomplete removal of tannin, affecting Clarity (the clarity of traditional Chinese medicine oral liquid has always been a thorny issue that plagues the development of modern Chinese medicine, and is the main factor affecting the quality of traditional Chinese medicine oral liquid
The molecular weight of some impurities is mostly macromolecules with a molecular weight of 20,000 or more, while the active ingredients are mostly small molecular substances. It is difficult to effectively remove protein, tannin and other macromolecular impurities in the liquid medicine by ordinary filtration methods.) Proteins cannot be effectively removed method, the traditional alcohol precipitation consumes a large amount of organic solvents, which seriously affects the quality of the product
Therefore, it has seriously hindered the sales and development of products, greatly restricted people's demand for medication, and is difficult to adapt to the requirements of modernization and internationalization of traditional Chinese medicine preparations

Method used

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Effect test

preparation example Construction

[0030] A kind of preparation method of the traditional Chinese medicine oral liquid that is used for the treatment of ADHD in children, the preparation technology that it adopts comprises the following steps:

[0031] (1) Taking medicine: take 16 kg of Rehmannia glutinosa, 12 kg of Ligustrum lucidum, 9 kg of Chinese yam, 2 kg of Schisandra chinensis, 16 kg of keel, 4 kg of polygala, 9 kg of Shichangpu, 2 kg of Zhimu, 4 kg of Cortex Phellodendri, and Moutan bark 8 kg, Alisma 9 kg, Poria cocos 9 kg; (2) Decoction: first break the keel of the above weight to 2.5cm 3 The following fragments, then put the fragmented keel into the extraction tank, add 8-12 times the amount of water, heat and decoct for 1.5-2.5 hours, then put the eleven traditional Chinese medicines of the above weight into the extraction tank together, and then Add water 8-10 times the mass of the total medicinal materials into the extraction tank, heat and decoct the extraction tank for 1.5-2.5 hours for the first...

Embodiment 1

[0035] Take 16kg of keel and break it to 2.5cm 3 The following fragments, then put the fragmented keel into the extraction tank, add 160 kg of water, decoct for 1 hour, and then put it into the extraction together with 16 kg of Rehmannia glutinosa and 68 kg of other eleven traditional Chinese medicines such as Ligustrum lucidum. In the tank, add 700 kg of water to the extraction tank, heat and decoct the extraction tank for the first time for 2 hours, take out the decoction, add 600 kg of water to the extraction tank for the second heating and decocting, After decocting for 1.8 hours, the decoction was taken out, and the secondary decoction was filtered through a 200-mesh sieve and combined. The combined decoction liquid is first filtered with a ceramic membrane with a pore size of 500nm to obtain the primary filtrate, the primary filtrate is fine-filtered with a ceramic membrane with a pore size of 100nm, the fine filtrate is ultrafiltered with a 5nm ultrafiltration membrane,...

Embodiment 2

[0037] Take 16kg of keel and break it to 2.5cm 3 The following fragments, then put the fragmented keel into the extraction tank, add 190 kg of water, decoct for 1.5 hours, and then put it into the extraction together with 16 kg of Rehmannia glutinosa and 68 kg of other eleven traditional Chinese medicines such as Ligustrum lucidum. In the tank, add 700 kg of water to the extraction tank, heat and decoct the extraction tank for the first time for 1.5 hours, take out the decoction liquid, and then add 600 kg of water to the extraction tank for the second heating and decocting, After decocting for 1.5 hours, take out the decoction, filter the secondary decoction through a 200-mesh sieve and combine. First filter the combined decoction liquid with a ceramic membrane with a pore size of 500nm to obtain the primary filtrate, then fine-filter the primary filtrate with a ceramic membrane with a pore size of 200nm, and then use a 5nm ultrafiltration membrane to ultrafiltrate the fine f...

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Abstract

The invention belongs to the technical field of traditional-Chinese-medicine oral liquid preparation, and particularly relates to a method for preparing traditional-Chinese-medicine oral liquid for treating child hyperactivity.The traditional-Chinese-medicine oral liquid comprises 8-11 parts of prepared rehmannia roots, 3-6 parts of glossy privet fruits, 3-5 parts of rhizoma dioscoreae, 1-3 parts of the fruits of Chinese magnoliavine, 6-9 parts of dragon bone, 2-5 parts of polygala roots, 3-5 parts of rhizoma acori graminei, 1-3 parts of rhizoma anemarrhenae, 2-5 parts of golden cypress, 2-4 parts of moutan bark, 2-5 parts of rhizoma alismatis and 2-5 parts of poria cocos.The preparing technology includes the following steps of decoction, ceramic membrane primary filtration, ceramic membrane secondary filtration refinement, ceramic ultrafiltration membrane ultrafiltration, reverse osmosis concentration, vacuum concentration, refrigeration, centrifugation and finished oral liquid preparation, and the obtained liquid is the traditional-Chinese-medicine oral liquid for treating child hyperactivity.The visceral dysfunction problem is solved by balancing yin and yang, the taste is relatively good, and the traditional-Chinese-medicine oral liquid is suitable for being taken by children; meanwhile, the active ingredients in the raw medicinal materials can be leached as far as possible, and the curative effect is remarkable.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicine oral liquid, and in particular relates to a preparation method of traditional Chinese medicine oral liquid for treating ADHD in children. Background technique [0002] Hyperkinetic syndrome (hyperkineticsyndromeofchildhood) is a common problem of abnormal behavior in children. Modern medicine calls it mild brain dysfunction or minimal brain dysfunction syndrome (minimal braindysfunction, MBD). Because the intelligence of these children is normal or basically normal, but they have defects in learning, behavior and emotion, manifested as inattention, short attention, excessive activities, and emotional impulsiveness, which affects the normal life and study of children. According to relevant statistics, the prevalence of ADHD in children accounts for about 1-10% of the total number of children. [0003] Western medicine mainly uses antidepressants, antipsychotics,...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61K9/08A61K47/26A61P25/14A61K35/02
CPCA61K36/8964A61K9/0095A61K35/02A61K36/076A61K36/57A61K36/638A61K36/69A61K36/71A61K36/756A61K36/79A61K36/804A61K36/884A61K36/888A61K36/8945A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 王进波王震
Owner LIAONING ORIENTAL PHARMA
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