A thermosensitive gel matrix and its preparation method and application
A temperature-sensitive gel matrix and a technology for preparing drugs, which are used in pharmaceutical formulations, medical preparations with inactive ingredients, and aerosol delivery, etc., can solve the problems of fast drug release rate, easy depolymerization, and no research reports on Soluplus temperature-sensitive gel. , to achieve the effect of convenient administration
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0046] Example 1: Comparison of the gelation temperature of Soluplus and Poloxamer 407 systems with the same solid content
[0047] Reagents required: Soluplus, Poloxamer 407, 50 mM phosphate buffer.
[0048] Preparation of 50mM phosphate buffer: weigh NaH 2 PO 4 7.8g, add 1000mL degassed water for injection to dissolve, and then adjust the pH to 7.4 with NaOH.
[0049] Precisely weigh 20 g each of Soluplus and Poloxamer 407, add 50 mM phosphate buffer to 100 g, and disperse at 4°C to prepare a dispersion system with a solid content of 20%. Using the overturning method, put the test product in the glass bottle, start to heat up from a water bath at 15°C, the temperature rise rate is 1.0°C / min, and maintain 2min at each temperature point, tilt the glass bottle at 60°, until the test sample remains stagnant for 30s The temperature is the gelation temperature.
[0050] From figure 1 It can be seen that the Soluplus blank gel with 20% solid content is a light blue opalescent n...
Embodiment 2
[0051] Example 2: Comparison of the gelation temperature of Soluplus and Poloxamer 407 systems with different solid contents
[0052] Reagents required: Soluplus, Poloxamer 407, water.
[0053] Accurately weigh the appropriate amount of Soluplus and Poloxamer 407 respectively, add water to 100g each, and disperse at 4°C to prepare a dispersion system. Using the flipping method, put the test product in the glass bottle, start to heat up from a water bath at 15°C, the temperature rise rate is 1.0°C / min, and maintain each temperature point for 2min, tilt the glass bottle at 60°, until the test sample remains stagnant for 30s The temperature is the gelation temperature.
[0054] The results showed that if the concentration of Soluplus is lower than 5%, it will not gel even if the temperature reaches 70°C; if the concentration is greater than 50%, it will become jelly at 15°C and cannot be injected. If the concentration of poloxamer 407 is lower than 15%, it cannot gel at 70°C; i...
Embodiment 3
[0055] Example 3: Comparison of the gelation temperature of Soluplus and Poloxamer 407 systems in different media
[0056] Reagents required: Soluplus, Poloxamer 407, water, 50 mM phosphate buffer, 0.9 wt% NaCl solution, isotonic phosphate buffer.
[0057] The preparation method of 50mM phosphate buffer solution is the same as that in Example 1.
[0058] Preparation of isotonic phosphate buffer: weigh 8g of NaCl, KH 2 PO 4 0.2g, Na 2 HPO 4 12H 2 Add 2.9g of O and 0.2g of KCl into the container, then add 1000mL of degassed purified water to dissolve, and adjust the pH to 7.4 with NaOH.
[0059] Accurately weigh the appropriate amount of Soluplus and Poloxamer 407 respectively, add different media to 100g, and disperse at 4°C to prepare a dispersion system. Using the flipping method, put the test product in the glass bottle, start to heat up from a water bath at 15°C, the temperature rise rate is 1.0°C / min, and maintain each temperature point for 2min, tilt the glass bott...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More