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Medicine for reducing body injuries caused by influenza virus infection

An influenza virus infection and drug technology, applied in the fields of immunology and epidemiology, can solve the problems of rare research reports and achieve the effect of strong clinical significance

Inactive Publication Date: 2016-07-20
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few research reports on the antiviral aspects of natural plant extracts in clinical research on influenza and influenza virus

Method used

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  • Medicine for reducing body injuries caused by influenza virus infection
  • Medicine for reducing body injuries caused by influenza virus infection
  • Medicine for reducing body injuries caused by influenza virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Medicines for Reducing Influenza Virus Infection-Induced Body Damage, Its Preparation Method and Application

[0024] The emulsion provided in this example for alleviating body damage caused by influenza virus infection is obtained by adding diallyl disulfide (DADS) into sterile corn oil, stirring for about 10 minutes, and dissolving completely.

[0025] 1. Infection of mice with influenza virus: Male C57BL / 6 mice aged 2-3 months and weighing about 25 g were randomly divided into control group, experimental group 1, experimental group 2, and experimental group 3, with 10 mice in each group. After mild ether anesthesia, the mice in the control group and the three experimental groups were inoculated with 50 μl (3000 pfu) of influenza virus WSN virus solution nasally. After the mice in the control group were inoculated with the virus, the mice were inoculated with 0.1 mL of corn oil. After the mice in the three experimental groups were inoculated with the virus, ...

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Abstract

The invention provides a medicine for reducing body injuries caused by influenza virus infection.The effective ingredient is diallyl disulfide.According to the medicine, it is indicated that the diallyl disulfide has the protective effect on mice subjected to influenza virus infection for the first time, the found mechanism has high clinical significance, and a firm foundation is laid for optimizing prevention measures and treatment methods of influenza.

Description

technical field [0001] The invention relates to the fields of immunology and epidemiology, in particular to a medicine for alleviating body damage caused by influenza virus infection. Background technique [0002] Influenza is one of the most common infectious diseases in humans. Influenza viruses continue to mutate as they circulate among poultry, livestock, and humans. The threat of new recombinant viruses that cross species barriers is always present. [0003] In order to further study the pathogenic mechanism of influenza virus, it is usually necessary to construct an animal model of influenza virus infection in BALB / c. The influenza virus isolated directly from the infected human body does not effectively infect mice at first, and needs to be continuously passaged in mice. Change the virulence and pathogenicity of the strain to make a mouse lung-adapted strain, so as to establish a mouse infection model of influenza virus. Some virulent strains do not need to carry out...

Claims

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Application Information

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IPC IPC(8): A61K31/105A61P29/00A61P31/16A61P39/00A23L33/10
CPCA61K31/105A23V2002/00A23V2200/30A23V2250/212
Inventor 李向东郭仰东姚建飞
Owner CHINA AGRI UNIV
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