Multi-spray head biological 3D printing equipment capable of batching and mixing materials automatically and control method for multi-spray head biological 3D printing equipment

Abstract

The invention discloses multi-spray head biological 3D printing equipment capable of batching and mixing materials automatically and a control method for the multi-spray head biological 3D printing equipment, and belongs to the field of tissue engineering and biological 3D printing. Pneumatic supplies of pneumatic material pressing tanks are connected with the inlets of solenoid directional valves; the outlets of the solenoid directional valves are connected with spray heads; when the pneumatic supplies supply pressure and the solenoid directional valves are electrified, biological materials in the pneumatic material pressing tanks can be pressed into a material mixing cylinder in proportions, and are mixed uniformly through a stirrer in a material mixing tank assembly. The material mixing tank assembly is connected with the pneumatic supplies and the inlets of the solenoid directional valves; the outlets of the solenoid directional valves are connected with the spray heads; when the pneumatic supplies supply the pressure and the solenoid directional valves are electrified, the biological materials in the pneumatic material pressing tanks can be pressed out from the spray heads; and the spray heads complete printing work according to a preset route under the cooperated movement of a moving top beam and a material taking driving arm. The multi-spray head biological 3D printing equipment capable of batching and mixing the materials automatically and the control method for the multi-spray head biological 3D printing equipment have the advantages that the materials can be batched and mixed quickly and automatically; multiple printing requirements can be met by the spray heads; printing performance can be played better; flexible control is easy to realize; the printing efficiency is improved.

Description

technical field [0001] The invention relates to a multi-nozzle biological 3D printing device with automatic batching and mixing, which is used for printing cells and biological materials, and belongs to the field of tissue engineering technology and biological 3D printing. Background technique [0002] For the treatment of damaged large soft tissues and internal organs, human tissue and organ transplantation is an extremely effective treatment method. However, due to the shortage of organ donor sources, immune rejection and other problems, there are insurmountable difficulties in the practical application of organ transplantation. The proposal of tissue engineering has opened up a new way to solve the above problems. Tissue engineering is to attach living cells to biomaterial matrices or prepared scaffolds by a certain method to construct functional tissue substitutes. Then the constructed tissue substitutes are cultured and implanted into the patient's body to replace the...

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Problems solved by technology

[0004] Chinese patent (application number 2010101932132) relates to a multi-nozzle injection device for a complex organ precursor three-dimensional controlled forming machine; Chinese patent (application number 201010193223.6) relates to a multi-nozzle injection device for a complex organ precursor three-dimensional controlled forming machine; The Chinese patent (Application No. 200910099785.0) relates to a turntable multi-nozzle complex organ precursor three-dimensional controlled forming system. The above three patents are applied to the controlled assembly of various cell materials, and their common feature is the use of multiple nozzles (nozzles) The same), when working, by switching between each other, the work efficiency is low. Although it is a variety of materials, it is not easy to mix the materials evenly when printing one by one

Chinese patent (201210065932.5) relates to a single-nozzle injection device for multi-material source delivery for a three-dimensional controlled assembly machine for cells. A single nozzle is used to realize multi-material source printing. Although it can realize multi-material source switching on demand, it cannot perform proportional batching and Mixing materials, there are also situations where the stored material sources are less and inconvenient to replace

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