Pharmaceutical composition for treatment of gastric cancer and application of pharmaceutical composition for treatment of gastric cancer

A composition and drug technology, applied in the field of medicine, can solve problems such as large side effects and unsustainable drug effect, and achieve the effects of inhibiting growth, improving drug safety, and reducing bleeding risk.

Inactive Publication Date: 2016-08-10
QINGDAO YUNTIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the technical deficiencies of the existing drugs for treating gastric cancer, which have relatively large side effects and unsustainable drug effects, the present invention provides a pharmaceutical composition for treating gastric cancer, which consists of lenvatinib and rhein

Method used

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  • Pharmaceutical composition for treatment of gastric cancer and application of pharmaceutical composition for treatment of gastric cancer
  • Pharmaceutical composition for treatment of gastric cancer and application of pharmaceutical composition for treatment of gastric cancer
  • Pharmaceutical composition for treatment of gastric cancer and application of pharmaceutical composition for treatment of gastric cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 compound tablet

[0020]

[0021] Preparation process: mix rhein and lenvatinib with auxiliary materials microcrystalline cellulose and starch evenly, add an appropriate amount of 15% starch slurry to make a soft material, and then granulate through a 16-mesh sieve. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0022] The preparation of embodiment 2 compound tablet

[0023]

[0024] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0025] The preparation of embodiment 3 compound dispersible tablets

[0026]

[0027]

[0028] Preparation process: Weigh rhein and lenvatinib according to the prescription quantity, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60% ethanol solution as Adhesive, micronized silica gel as flow aid, granulated in one step by fluidized bed, and then compressed into tablets.

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Abstract

The invention belongs to the technical field of medicines and relates to a pharmaceutical composition for treatment of gastric cancer and application of the pharmaceutical composition for treatment of gastric cancer. The pharmaceutical composition for treatment of gastric cancer is provided to overcome technical defects of strong side effects and poor efficacies of existing medicines for treating gastric cancer and is composed of lenvatinib and rhein. The two medicinal active components have a remarkable synergistic effect on inhibition of in-vivo proliferation of human gastric cancer MGC-803.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating gastric cancer and its application, belonging to the technical field of medicine. Background technique [0002] At present, cancer is one of the major diseases that seriously affect human health and threaten human life. Together with cardiovascular and cerebrovascular diseases and accidents, cancer constitutes the top three causes of death in all countries in the world today. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. There are three main ways to treat cancer in the world. One is to use surgical resection to remove the diseased tissue to prevent the spread of cancer cells; the other is to use chemotherapy or radiotherapy to kill cancer cells; the third is to use drugs to treat it. Adopt the method for surgical excision to increase patient's misery, hurt its vitality, and expen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/192A61P35/00
CPCA61K31/47A61K31/192A61K2300/00
Inventor 王传秀
Owner QINGDAO YUNTIAN BIOTECH
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