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Layered vascular stent forming system and method based on electrostatic direct writing and electrospinning technology

An electrospinning technology and a vascular stent technology, which are applied in the fields of mechanical manufacturing and biomanufacturing, can solve problems such as three-layer structures that are difficult to stent, and achieve the effects of high stent strength, improved efficiency, and easy control

Active Publication Date: 2018-03-02
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these traditional methods have obtained more successful vascular stents or stents with a vascular network, it is difficult to achieve a three-layer structure of the stent in the current process for preparing vascular stents.

Method used

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  • Layered vascular stent forming system and method based on electrostatic direct writing and electrospinning technology
  • Layered vascular stent forming system and method based on electrostatic direct writing and electrospinning technology
  • Layered vascular stent forming system and method based on electrostatic direct writing and electrospinning technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] see Figure 1 ~ Figure 3, a layered vascular stent forming system based on electrostatic direct writing and electrospinning technology, comprising a feeding system I, a spinning collection system II, a three-axis motion platform 3, a power supply 4 and a computer control system 5, characterized in that: The feeding system I is arranged on the Z-axis slider of the three-axis moving platform 3; the spinning collection system II is fixedly installed on the XY-axis platform of the three-axis moving platform 3, so that the syringe needle 14 of the feeding system I The axis is perpendicular to the axis of the mandrel 22 of the spinning collection system II; the positive pole of the power supply 4 is connected to the metal part of the syringe needle 14, and the negative pole is connected to the metal part of the mandrel 22; the computer control system 5 and the three-axis motion platform 3 Electrically connected to control the three-dimensional movement of the three-axis motio...

Embodiment 2

[0032] This embodiment is basically the same as Embodiment 1, and the special features are as follows:

[0033] Described feeding system 1 comprises micropump controller 11, micropump actuator 12, syringe piston barrel 13 and syringe needle 14; Described micropump actuator 12 is fixed on the Z-axis slide block of three-axis motion platform 3 , the Z-axis slider drives the micropump actuator 12 to move along the Z-axis direction, the syringe piston cylinder 13 is fixedly mounted on the micropump actuator 12, the syringe needle 14 is fixed on the bottom end of the syringe piston cylinder 13, and the micropump The actuator 12 is connected and driven by the micropump controller 11 to push the syringe piston cylinder 13 to extrude the spinning material.

[0034] The spinning collection system II consists of a stepper motor 21, a mandrel 22, a spinning collection frame 23, a shaft coupling 24, a first bearing end cover 25, a deep groove ball bearing 26, a sleeve 27 and a second bear...

Embodiment 3

[0037] A layered vascular stent forming method based on electrostatic direct writing and electrospinning technology, using the above-mentioned layered vascular stent forming system based on electrostatic direct writing and electrospinning technology to operate, the operation steps are as follows:

[0038] 1) The innermost layer of the shaped vascular stent: adjust the distance between the syringe needle 14 and the mandrel 22 to meet the conditions for electrospinning, the positive pole of the power supply 4 is connected to the metal part of the syringe needle 14, and the negative pole is connected to the mandrel 22 The metal part, so that a high-voltage electric field is formed between the syringe needle 14 and the mandrel 22. Under the joint action of the thrust of the micropump actuator 12 and the electrostatic field force, the syringe needle 14 ejects nano-scale fiber filaments, and at the same time The motor 21 drives the mandrel 22 to rotate at a constant rate, and the XY ...

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Abstract

The invention discloses a layered intravascular stent forming system and method based on an electrostatic direct writing and electrospinning technology. The system comprises a feeding system, a spinning fiber collection system, a three-axis movement platform, a power source and a computer control system. The feeding system drives extrusion of materials through a micro pump execution mechanism. The spinning fiber collection system receives electrospinning fire through rotation of a stepping motor and drive of the three-axis movement platform. The three-axis movement platform drives the spinning fiber collection system to receive electrospinning fiber. The power source forms a high voltage electric field between an injector needle and a core shaft, and electrospinning and electrostatic direct writing processes are achieved. The computer control system drives the three-axis movement platform to move. The advantages of electrostatic direct writing and advantages of electrospinning are combined, electrospinning and the electrostatic direct writing are carried out successively, and finally an intravascular stent of a three-layer structure with good mechanical performance is formed.

Description

technical field [0001] The invention relates to a layered vascular stent forming system and method based on electrostatic direct writing and electrospinning technology, which can realize the preparation of a layered vascular stent and is applied in the technical fields of mechanical manufacturing and biomanufacturing. Background technique [0002] In recent years, cardiovascular disease has gradually become an important factor that threatens health. Due to the lack of suitable autologous blood vessels, a large number of patients need artificial blood vessel transplantation every year. The construction of functional tissue vascular scaffolds has broad application prospects. [0003] The inner diameter of blood vessels in the human body ranges from 5 microns to 25 mm, and the walls of larger blood vessels have an obvious three-layer structure: intima, media and adventitia. The intima is a single layer of endothelial cells attached to the basement membrane; the media is compos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D5/00A61F2/07
CPCA61F2/07A61F2240/001D01D5/0061D01D5/0076
Inventor 刘媛媛蒋维健谢明亮孙振林胡庆夕
Owner SHANGHAI UNIV
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