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Vasodilator formulation and method of use

A technology of vasodilator and preparation, applied in the field of local vasodilator preparation

Inactive Publication Date: 2016-08-17
ATP INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] While many currently available topical vasodilator formulations increase or enhance blood flow to some extent, there remains an ongoing interest in identifying new formulations that provide longer-lasting vasodilatory effects without undesired side effects

Method used

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  • Vasodilator formulation and method of use
  • Vasodilator formulation and method of use
  • Vasodilator formulation and method of use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0173] A topical vasodilator formulation comprising 2.5% arginine hydrochloride, 0.25% black pepper essential oil, and 0.25% peppermint essential oil was prepared according to the following formulation (Table 1) to provide a formulation suitable for use, eg, in a pump device.

[0174] The formulation can be used to enhance the muscle and / or vascular lines of a subject, especially a bodybuilder.

[0175] Approximately 5% blue ear grass extract (providing 50% 20-hydroxyecdysterone) and 2.5% arginine hydrochloride were micronized to form a powder and combined with a humectant ethanol. In a separate vessel, form the base by heating the oil phase in the vessel to 60 degrees and then heating the water phase in a separate vessel to 60 degrees. The oil and water phases are then combined to form an emulsion. Micronized powder was added to the base using geometric dilution: 5% blue ear grass extract (providing 50% of 20-hydroxyecdysterone) and 2.5% arginine hydrochloride. The black pe...

Embodiment 2

[0179] A topical vasodilator formulation comprising 2.5% arginine hydrochloride, 0.25% black pepper essential oil and 0.25% peppermint essential oil was prepared according to the following formulation (Table 2) to provide a formulation suitable for use in, eg, a pump device.

[0180] The present formulation may be used in the treatment of a disease, disorder or condition associated with a reduction and / or impairment of blood flow in a subject, in particular peripheral blood flow, suitably diabetes mellitus.

[0181] Approximately 5% blue ear grass extract (providing 50% 20-hydroxyecdysterone) and 2.5% arginine hydrochloride were micronized to form a powder and combined with a humectant ethanol. The base was formed by heating the oil phase to 60 degrees in a container and then the water phase to 60 degrees in a separate container. The oil and water phases are then combined to form an emulsion. Micronized powder 5% blue ear grass extract (providing 50% 20-hydroxyecdysterone) an...

Embodiment 3

[0185] A topical vasodilator formulation comprising 2.5% arginine hydrochloride, 0.25% black pepper essential oil and 0.25% peppermint essential oil was prepared according to the following formulation (Table 3) to provide a formulation suitable for use in, eg, a pump device.

[0186] The formulations are useful in the treatment of diseases, disorders or conditions associated with a reduction and / or impairment of blood flow in a subject, in particular the treatment of erectile dysfunction and female sexual dysfunction.

[0187] Approximately 5% blue ear grass extract (providing 50% 20-hydroxyecdysterone) and 2.5% arginine hydrochloride were micronized to form a powder and combined with a humectant ethanol. The base was formed by heating the oil phase to 60 degrees in a container and then the water phase to 60 degrees in a separate container. The oil and water phases are then combined to form an emulsion. A micronized powder of 5% blue ear grass extract (providing 50% of 20-hyd...

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Abstract

A topically admimstrable vasodilator formulation comprises arginine and / or one or more derivatives thereof, black pepper extract and / or one or more components or derivatives thereof; and peppermint extract and / or one or more components or derivatives thereof. The formulation may further comprise rosemary oil, a penetration enhancers, an ecdysteroid and / or one or more other agents that enhance the vasodilator activity of the formulation. The valodilalor formulation may be suitable for treating or preventing a disease, disorder or condition associated with a decrease and / or impairment of blood flow in a subject by topically administration to the subject.

Description

technical field [0001] The present invention relates to topical vasodilator formulations and methods of treatment and / or use. The formulations are useful in a wide range of cosmetic and / or therapeutic applications such as enhancing muscle definition and aiding in the therapeutic management of diabetes. Background technique [0002] Approaches to improving blood flow to the skin are numerous and include systemic and topical approaches. Subjects experience many beneficial effects through improved local blood flow, as impairment of local blood flow leads to a variety of negative outcomes, among which are cold hands and feet, hair loss, leg ulcers, certain forms of impotence, and a variety of others illness. [0003] Arginine is a naturally occurring amino acid that participates in many important biochemical reactions essential to the normal physiological function of a subject. This amino acid is present in most proteins consumed in the human daily diet and can be metabolized...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K36/534A61K36/67A61P9/08
CPCA61K31/198A61K36/534A61K9/0014A61K45/06A61Q7/00A61K47/06A61K47/10A61K47/12A61K47/22A61K9/107A61K8/44A61K2800/5922A61K36/67A61K8/9789A61K8/9794A61P9/08A61K2300/00A61K8/062A61K8/678A61K31/355A61K36/185A61K36/53A61K47/46A61K2800/592A61Q19/08
Inventor M·莱格
Owner ATP INST
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