Pharmaceutical composition containing Chinese herbal medicines and used for preventing dental caries

A technology of composition and Chinese herbal medicine, which is applied in the direction of drug combination, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of insignificant antibacterial effect, high production cost, and difficulty in determining active ingredients, and achieve no reproductive toxicity , Human body safety and non-toxic effect

Inactive Publication Date: 2016-08-24
QINGDAO UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing formulas containing multiple Chinese herbal ingredients are complicated, the active ingredients are difficult to determine, the production cost is high, and the antibacterial effect is not significant. Therefore, it is necessary to develop a Chinese medicine formula with definite antibacterial effect and simple formula for preventing dental caries

Method used

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  • Pharmaceutical composition containing Chinese herbal medicines and used for preventing dental caries
  • Pharmaceutical composition containing Chinese herbal medicines and used for preventing dental caries
  • Pharmaceutical composition containing Chinese herbal medicines and used for preventing dental caries

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Experimental program
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Effect test

Embodiment

[0021] 1 Test materials and reagents

[0022] 1.1 Phellodendron Phellodendron was purchased from Shenzhen China Resources Sanjiu Pharmaceutical Co., Ltd. The active antibacterial component of the original drug, berberine hydrochloride, contained 4.81%, and it was made into a 1:12 extract when used.

[0023] 1.2 Folium Folium extract was purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd., the main active ingredient indirubin content was 1.05%, and it was made into a 1:5 extract when used.

[0024] 1.3 Dental caries indicator bacteria Streptococcus mutans (ATCC35668) and Lactobacillus (ATCC4546) were purchased from Beijing Yuding Xinjie Technology Co., Ltd.

[0025] 1.4 Brain heart infusion agar medium was purchased from Qingdao High-tech Park Haibo Biotechnology Co., Ltd., and MRS medium was purchased from Qingdao Nisaixinhe Biotechnology Co., Ltd.

[0026] 2 Test methods and results

[0027] 2.1 Antibacterial ring test of single antibacterial substance

[002...

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Abstract

The invention provides a pharmaceutical composition containing Chinese herbal medicines and used for preventing dental caries. The pharmaceutical composition consists of Cortex Phellodendri and Folium Isatidis according to the weight ratio of (0.9-1.1): (0.9-1.1). The pharmaceutical composition can be prepared into collutory, and has good inhibition effect on cariogenic bacteria lactobacillus and streptococcus mutans, particularly, Cortex Phellodendri and Folium Isatidis are matched with each other, the action concentration Cortex Phellodendri and Folium Isatidis which are combined is lower than the action concentration of Cortex Phellodendri and Folium Isatidis which are used independently, and therefore, the synergistic effect is achieved by matching Cortex Phellodendri with Folium Isatidis. The raw materials used in the pharmaceutical composition are extracted from plants, do not contain any chemical addition agents, do not irritate mucosa, do not have reproduction toxicity and is safe and non-toxic to human bodies.

Description

technical field [0001] The invention belongs to the field of preventive medicine and relates to a pharmaceutical composition containing Chinese herbal medicine for preventing dental caries. Background technique [0002] Dental caries is a common and frequently-occurring disease of human beings. It is the third disease that needs to be prevented and treated after cardiovascular disease and cancer. 60% to 90% of children and adults in the world have suffered from dental caries. In 2010, more than 5 billion people in the world suffered from dental caries, and the incidence rate of dental caries in China was as high as 70% to 80%, and it was as high as 90% in infants and young children. The prerequisite for the occurrence of dental caries is the growth and acid production of cariogenic bacteria. Cariogenic bacteria are the resident microorganisms in the oral cavity. Among them, Streptococcus mutans and Lactobacillus are closely related to dental caries, and can ferment a variety...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P1/02A61P31/04
CPCA61K36/315A61K36/756A61K2300/00
Inventor 王斌鲁晓晴李万通王海涛闫志勇
Owner QINGDAO UNIV
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