Applications of Chinese torreya essential oil in preparing anti-inflammatory medicines and cosmetics

A technology of anti-inflammatory drugs and cosmetics, applied in the field of natural medicinal chemistry, can solve the problems of anti-inflammatory use of Torreya essential oil, etc.

Inactive Publication Date: 2016-09-07
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no use of Torreya essential oil in anti-inflammation in the present technology

Method used

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  • Applications of Chinese torreya essential oil in preparing anti-inflammatory medicines and cosmetics
  • Applications of Chinese torreya essential oil in preparing anti-inflammatory medicines and cosmetics
  • Applications of Chinese torreya essential oil in preparing anti-inflammatory medicines and cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Extraction of fresh Torreya aril essential oil by distillation and cold pressing:

[0019] Fresh torreya aril refers to the green torreya cortex that has been stored at room temperature for no more than 1 day. To extract essential oil from fresh torreya aril, the method of first cutting the cortex into small pieces and adding 2 to 3 times of water to carry out water distillation for 2 to 4 hours, Or use a screw cold press to squeeze the juice, after the obtained juice is centrifugally precipitated by a centrifuge (the centrifuge speed is 5000 rpm, and the time is 20 minutes), the supernatant is distilled, and the distillate is separated by an oil-water separator The essential oil of fresh Torreya arils is available. The oil yield of Torreya essential oil obtained from fresh Torreya arils is 0.35-0.45% (w / w, wet basis weight).

[0020] Carbon dioxide supercritical extraction of fresh Torreya aril essential oil:

[0021] 300g arils were chopped into 5×5mm or mashed into...

Embodiment 2

[0036] The present invention adopts Torreya essential oil as the active ingredient of the anti-inflammatory product. In order to confirm the anti-inflammatory effect of Torreya essential oil described in the present invention, the present invention carries out anti-inflammatory activity research on the essential oil obtained from the distillation of Torreya aril, The specific methods and results are as follows:

[0037] 1. The effect on mouse paw swelling caused by egg white:

[0038] Principle: subcutaneous injection of fresh egg white into the left toes of mice can induce swelling of the toes, which is similar to egg white stimulating the local production of a large amount of PGE 2 , histamine, malondialdehyde and other inflammatory stimuli.

[0039] Male ICR mice of 18-22 g were selected and divided into 6 groups. The details of the groups are shown in Table 1, with 10 mice in each group. Except for the indomethacin group, which was only intragastrically administered once...

Embodiment 3

[0052] Obtain Torreya quinquefolium essential oil by embodiment 1, make capsule by conventional capsule preparation method.

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Abstract

The invention belongs to the fields of natural medicines and cosmetics, and discloses applications of Chinese torreya essential oil in preparing medicines for treating inflammation-related diseases, and applications of Chinese torreya essential oil as the functional component in the cosmetics, so that the anaphylactic reaction of the cosmetics is reduced, and the anti-inflammatory repairing capacity of the skin is improved. The animal inflammation experiment proves that no matter after Chinese torreya essential oil is taken orally or externally applied, the mouse acute inflammation caused by egg white can be obviously inhibited, and in addition, the mouse acute inflammation caused by carrageenin also can be obviously inhibited. Chinese torreya essential oil is prepared from Chinese torreya aril through a distillation method, a cold pressing method, a solvent extraction method or a CO2 supercritical extraction method. The requirements for the quality of the Chinese torreya essential oil are as follows: the colourless or chartreuse liquid adopted has the characteristic aroma of Chinese torreya fruits, and has the relative density (at 20 DEG C / 20 DEG C) being 0.850-0.860, and the sum of the contents of the characteristic components alpha-pinene and limonene is greater than or equal to 30%. The invention discloses the novel applications of Chinese torreya essential oil in preparing the anti-inflammatory medicines or cosmetics. In addition, by comparing the advantages and disadvantages of different extraction methods of Chinese torreya essential oil, the invention provides a preferable preparation method of Chinese torreya essential oil.

Description

Technical field: [0001] The invention relates to the fields of natural medicinal chemistry and cosmetics, in particular to the application of Torreya torreya essential oil extracted from Torreya torreya aril as a raw material in anti-inflammatory medicine and cosmetics. Background technique: [0002] Torreya grandis (Torreya grandis), also known as Torreya grandis, Torreya grandis, etc., is an evergreen tree of the genus Torreya in the Taxaceae family. my country's Zhejiang, Jiangsu, Anhui, Fujian and other provinces, the main production areas are Zhuji, Shengzhou, Shaoxing, Dongyang, Pan'an and other places in the Kuaiji Mountain area of ​​Zhejiang Province. Torreya is a multi-purpose precious tree species that integrates food, medicine, oil, wood and ornamental greening. The fruit of Torreya torreya has been favored and affirmed all the time, but the thicker fleshy aril part of the outer layer of the seed, which accounts for 50-60% of the fresh weight of the seed, has not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/13A61P29/00A61K8/92A61Q19/00A61P37/08
CPCA61K36/13A61K8/922A61K9/0014A61K2236/331A61K2236/37A61K2236/53A61Q19/00
Inventor 杜芝芝李志坚顾健龙赵云丽张红霞骆冠军
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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