Application of liver protecting Buzure particles to preparation of medicament for treating cholestatic jaundice

A technology of hot granules and liver protection, applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effects of alleviating weight loss, high safety in animal experiments, and simple ingredients

Inactive Publication Date: 2016-09-07
新疆维吾尔药业有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no ideal drug for the treatment of cholestatic jaundice, therefore, the drug for the treatment of cholestatic jaundice needs further research

Method used

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  • Application of liver protecting Buzure particles to preparation of medicament for treating cholestatic jaundice
  • Application of liver protecting Buzure particles to preparation of medicament for treating cholestatic jaundice
  • Application of liver protecting Buzure particles to preparation of medicament for treating cholestatic jaundice

Examples

Experimental program
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Effect test

Embodiment 1

[0043] The cholestatic jaundice model of SD rats was established by one-time gavage of 1-naphthyl isothiocyanate. After 72 hours of poisoning, the blood, liver, pathological sections and other indicators of the rats were observed to evaluate the effect of the tested drug on the cholestatic jaundice. The pharmacodynamic effects of jaundice and its characteristics or advantages compared with similar drugs.

[0044] 1. Experimental materials

[0045] Animals: 60 SD rats, SPF grade, weighing 220-250 g, half male and half male, provided by Hubei Experimental Animal Research Center, animal license number: SCXK (E) 2008-0005.

[0046] Instruments: centrifuge, 96-well plate, 1.5ml Eppendorf tube, 5ml Eppendorf tube, 10ml Eppendorf tube, weighing balance, surgical instruments, microplate reader, light microscope.

[0047] Reagents and drugs: 1-naphthyl isothiocyanate, provided by Beijing Bailingwei Technology Co., Ltd., Lot: LSA0N13; formaldehyde, provided by Sinopharm Chemical Reagen...

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Abstract

The invention discloses liver protecting Buzure particles. The liver protecting Buzure particles comprise celery seeds, cichorium inrybus seeds, cuscuta chinensis seeds, celery roots, fennel root bark, cichorium inrybus roots and fennel. The liver protecting Buzure particles are used for treating cholestatic jaundice. The liver protecting Buzure particles have a good treatment effect on the cholestatic jaundice, and can also treat liver cold, stomachache, spleen blocking hypochondriac pain, joint bone pain, rheumatic diseases and urinary system diseases.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to Hugan Buzure Granules and its application in the preparation of medicines for treating cholestatic jaundice. Background technique [0002] Jaundice (jaundice) is a common symptom and sign, and its occurrence is caused by the increase of serum bilirubin concentration due to bilirubin metabolism disorder. There are many diseases that cause jaundice, but they are most common in liver diseases and biliary tract diseases. Others such as certain blood system diseases, pancreatic diseases, obstetrical diseases, and neonatal diseases (congenital jaundice) can also cause jaundice. Cholestatic jaundice refers to the obvious increase of total bilirubin due to cholestasis, especially the jaundice of direct bilirubin. and drugs etc. Cholestatic jaundice has a long course of disease and is difficult to treat. The main symptoms are jaundice and skin itching. [0003] At present, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/39A61K9/16A61P1/16
CPCA61K36/23A61K9/1605A61K36/28A61K36/39A61K2300/00
Inventor 王学海尹强许勇尹海龙马璇穆丹丹刘秋云章宝才黄璐刘腊才努尔拉江·帕合尔丁刘子甲
Owner 新疆维吾尔药业有限责任公司
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