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A multifunctional anticancer traditional Chinese medicine nanocarrier and its application

A nano-carrier and multi-functional technology, which can be used in anti-tumor drugs, pharmaceutical formulations, drug combinations, etc., and can solve problems such as expensive, difficult to control dispersion, and cumbersome steps

Active Publication Date: 2019-07-23
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composite nano-drug carrier needs to first prepare graphene oxide whose dispersion is difficult to control, and then graft transferrin through complex methods. Not only the method is complicated and the steps are cumbersome, but also the use of transferrin to provide iron source is expensive.

Method used

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  • A multifunctional anticancer traditional Chinese medicine nanocarrier and its application
  • A multifunctional anticancer traditional Chinese medicine nanocarrier and its application
  • A multifunctional anticancer traditional Chinese medicine nanocarrier and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0045] 1. Dissolve 0.3g of ferrocene in 30mL of acetone, after ultrasonic dispersion, add 1.5mL of aqueous hydrogen peroxide solution with a mass concentration of 30% dropwise, and stir magnetically at a speed of 1000r / min for 30min to obtain a mixed solution; The mixed solution was transferred to a 40mL autoclave, heated to 210°C under airtight conditions, and kept for 48 hours. After the reaction, cooled to room temperature to obtain a black powder; the black powder was washed three times with acetone and ethanol respectively, and vacuum Dry in an oven for 6 hours to obtain carbon-coated superparamagnetic ferric oxide nanoparticles.

[0046] The carbon-coated superparamagnetic ferric oxide nanoparticles prepared in step 1 are scanned by electron microscope, and the results are shown in Figure 4 . Figure 4 The 200,000-fold transmission electron micrograph of the carbon-coated superparamagnetic ferriferric oxide nanoparticles prepared for the embodiment of the present inven...

Embodiment 2

[0056] In the acetone solution of dihydroartemisinin, add the multifunctional anti-cancer traditional Chinese medicine nano-carrier of the present invention (coated 15 times), and ultrasonically disperse evenly to obtain a mixed solution; add 5 mL of deionized water dropwise to the mixed solution under stirring conditions, The dropping rate was controlled at 0.1-1mL / min. After the dropping, the stirring reaction was continued at 37°C for 24 hours at a stirring speed of 1000r / min. The acetone was completely volatilized, washed with deionized water and centrifuged to remove unloaded dihydroartemisinin. Vacuum-dry at 40°C for 6 hours to obtain drug-loaded particles.

[0057] The mass ratio of dihydroartemisinin, multifunctional anti-cancer traditional Chinese medicine nano-carrier and acetone is (0.04-0.1):(0.05-0.1):(7-8).

[0058] Infrared spectroscopic analysis was carried out on the drug-loaded particles, and the results can be found in Figure 9 . Depend on Figure 9 It c...

Embodiment 3

[0060] Add 5 mL of physiological saline to 11.15 mg of dihydroartemisinin and 25 mg of the drug-loaded particles prepared in Example 3, and disperse evenly by ultrasonication.

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Abstract

The invention discloses a multifunctional traditional Chinese medicinal anticancer nano-carrier and an application thereof, wherein the multifunctional traditional Chinese medicinal anticancer nano-carrier is in the form of carbon-coated superparamagnetic ferroferric oxide nanoparticles covered by an iron-based porous metal organic frame. The iron-based porous metal organic frame has a capacity of efficiently loading dihydroartemisinin; meanwhile, the iron-based porous metal organic frame, which covers the surfaces of the carbon-coated superparamagnetic ferroferric oxide nanoparticles, is degradable in a tumor cell slightly acidic environment, so that ferric ions and the dihydroartemisinin are synchronously released; the ferric ions are further reduced into bivalent ferrous ions by virtue of ferric reductase in cell, and the bivalent ferrous ions are capable of catalyzing the dihydroartemisinin to generate free radicals, so that the tumor cells are killed.

Description

[0001] 1. Technical field [0002] The invention relates to a multifunctional anticancer traditional Chinese medicine nano carrier and its application, belonging to the technical field of anticancer drug carriers. [0003] 2. Background technology [0004] Cancer is one of the biggest disease threats facing human beings. The incidence of cancer has been on the rise in the past 30 years. According to the report of the World Health Organization (WHO), the average annual new cancer cases in China are about 2.2 million, and the number of cancer deaths is about 1.6 million. In the past 20 years, the mortality rate of cancer in China has increased by nearly 30%, ranking first among the causes of death. [0005] Chemotherapy is still one of the main means of tumor treatment. At present, the vast majority of anticancer drugs widely used in clinical practice are still artificially synthesized. These drugs have serious toxic and side effects while treating cancer. It is an important to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/52A61K47/69A61K31/366A61P35/00
CPCA61K31/366
Inventor 陈乾旺汪冬冬陈汝慧
Owner UNIV OF SCI & TECH OF CHINA
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