Supercharge Your Innovation With Domain-Expert AI Agents!

Method for preparing pharmaceutic adjuvant Eudragit RS100 particle

A technology of pharmaceutical excipients and microparticles, which is used in pharmaceutical formulations, microcapsules, drug delivery and other directions to achieve the effects of easy control, stable and effective treatment of blood drug concentration, and improvement of bioavailability

Inactive Publication Date: 2016-09-21
HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among various microencapsulation technology methods, it is a new challenge to prepare drug particles with small particle size and uniform distribution

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing pharmaceutic adjuvant Eudragit RS100 particle
  • Method for preparing pharmaceutic adjuvant Eudragit RS100 particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Preparation of Eudragit RS100 spherical particles.

[0012] In this example, Eudragit RS100 polymer spherical particles were prepared by supercritical fluid forced dispersion solution technology. The device for preparing particles is a supercritical fluid forced dispersion solution technology (SEDS) device, such as figure 1 Shown.

[0013] (1) First, weigh 80 mg of Eudragit RS100 and dissolve it in 10 ml of N,N dimethylformamide solvent, then add a certain quality of PVP to fully dissolve it.

[0014] (2) The temperature in the water bath is controlled by the heater to the accuracy of ±0.1℃. CO provided by the cylinder 2 The plunger pump is injected into the entire device, and the ISCO pump controls the pressure of the system. After rising to the set pressure, it is accurate to ±0.1MPa, and the device pressure and temperature are stabilized for 30 minutes.

[0015] (3) Then, open and adjust CO 2 Under the condition that the pressure of the ISCO pump control system does not cha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for preparing a pharmaceutic adjuvant Eudragit RS100 particle. The method processes the Eudragit RS100 polymer solution of polyvinylpyrrolidone (A) added a dispersing agent (B) by solution-enhanced dispersion by supercritical technology to obtain the polymer particle, and is used for preparing slow / controlled-release particle pharmaceutic preparation. The medicine can be performed microparticulation (microencapsulation) by means of the method condition of preparing particle by the pharmaceutic adjuvant controlled-release packing material Eudragit RS100, the side effects of pharmaceutical medicine and the frequency of taking medication are reduced, and the use ratio of the medication in vivo is improved.

Description

Technical field [0001] The invention relates to a method for preparing slow / controlled release coating material polymer particles in the medical field. Background technique [0002] The microencapsulation of drugs is to use natural or synthetic medicinal polymer materials as capsule materials to disperse or encapsulate drugs in the materials to form particles. Compared with other sustained-release and controlled-release preparation technologies (such as matrix-type controlled-release tablets, coated sustained-release technology, osmotic pump formulations, etc.), the slow / controlled release of drug particles is easy to adhere due to the small particle size of the drug particles. It can increase the contact area and contact time between the drug and the site of action, and has high bioavailability; at the same time, it can reduce the interaction and compatibility changes of the compound drug; not only can control the release rate of the drug, but also modify the surface of the drug...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/50A61K47/32
CPCA61K9/1635A61K9/0002A61K9/50A61K47/32
Inventor 王辉甄崇礼卢建红
Owner HANGZHOU INST OF ADVANCED MATERIAL BEIJING UNIV OF CHEM TECH
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com