Process method for extracting rhynchophylline from uncaria rhynchophylla

A process method and technology of urticine, applied in the field of plant active ingredient extraction, can solve problems such as restricting research, development and application of plant active active ingredients, inability to apply industrialized production practices, poor water solubility of active ingredients, etc. The speed of diffusion, the shortening of extraction time, the effect of improving solubility

Inactive Publication Date: 2016-09-21
唐翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, many domestic and foreign scholars have continuously explored and optimized the extraction process of plant effective active ingredients, and some new extraction and separation technologies have emerged, such as microwave, ultrasonic, ultrafine pulverization, supercritical, etc. Although these new Technology has made significant progress compared with traditional technology, but the problems of poor water solubility and low utilization of active ingredients have not been fundamentally solved, and some technologies are limited to laboratory research due to special equipment, and cannot be applied to industrial production practice
It can be seen that the imperfection of extraction technology has always been a key issue restricting the further research, development and application of effective plant active ingredients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A process for extracting rhynchophylline from Uncaria, specifically comprising the following steps:

[0021] (1) Take the traditional Chinese medicine Uncaria uncaria, crush it, and pass through a 30-mesh sieve to obtain Uncaria powder;

[0022] (2) Put Uncaria powder and sodium carbonate in a planetary mill or vibratory mill for 20 minutes in a weight ratio of 95:5 to obtain mixed micropowder;

[0023] (3) Put the mixed micropowder and 65% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g:8ml, and conduct ultrasonic countercurrent extraction for 20 minutes under the action of ultrasonic waves with a frequency of 50KHz, a power of 400w, and a temperature of 20°C , filter the extract, collect the filtrate and filter residue; repeat the ultrasonic countercurrent extraction of the filter residue twice, repeat the filtration, and finally combine all the filtrates to obtain the total filtrate; ...

Embodiment 2

[0028] A process for extracting rhynchophylline from Uncaria, specifically comprising the following steps:

[0029] (1) Take the traditional Chinese medicine Uncaria uncaria, crush it, and pass through a 50-mesh sieve to obtain Uncaria powder;

[0030] (2) Put Uncaria powder and sodium carbonate in a planetary mill or vibratory mill for 30 minutes in a weight ratio of 96:4 to obtain mixed micropowder;

[0031] (3) Put the mixed micropowder and 60% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 10ml, and perform ultrasonic countercurrent extraction for 15 minutes under the action of ultrasonic waves with a frequency of 60KHz, a power of 450w, and a temperature of 30°C , filter the extract, collect the filtrate and filter residue; repeat the ultrasonic countercurrent extraction of the filter residue 3 times, repeat the filtration, and finally combine all the filtrates to obtain the total filtra...

Embodiment 3

[0036] A process for extracting rhynchophylline from Uncaria, specifically comprising the following steps:

[0037] (1) Take the traditional Chinese medicine Uncaria uncaria, crush it, and pass through a 50-mesh sieve to obtain Uncaria powder;

[0038] (2) Put Uncaria powder and sodium carbonate in a planetary mill or vibratory mill for 10 minutes in a weight ratio of 98:2 to obtain mixed micropowder;

[0039] (3) Put the mixed micropowder and 55% ethanol into a single-stage continuous countercurrent ultrasonic extraction machine according to the material-to-liquid ratio of 1g: 12ml, and conduct ultrasonic countercurrent extraction for 30 minutes under the action of ultrasonic waves with a frequency of 80KHz, a power of 300w, and a temperature of 10°C , filter the extract, collect the filtrate and filter residue; repeat the ultrasonic countercurrent extraction of the filter residue twice, repeat the filtration, and finally combine all the filtrates to obtain the total filtrate...

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Abstract

The invention discloses a process method for extracting rhynchophylline from uncaria rhynchophylla. The process method comprises the steps that the uncaria rhynchophylla is pretreated, mixing grinding is carried out through the micro cutting interaction technology; ethanol extraction is carried out in a single-stage continuous countercurrent ultrasonic extractor; a sample is fed to a resin chromatographic column; eluant is dried, and the rhynchophylline is obtained. Compared with the prior art, the rhynchophylline is extracted with the assistance of the micro cutting assisted interaction technology, the solubility of the rhynchophylline in an ethanol solution can be effectively improved in a submicron powder state, and the eduction rate of the rhynchophylline is further increased. In the rhynchophylline ethanol extraction process, under the action of ultrasonic waves, the continuous countercurrent extraction technology is adopted in assistance, the permeating dissolving and dispersing speed in the rhynchophylline extraction process can be increased, the extraction time is shortened, the use amount of a solvent can be reduced, and the method for extracting rhynchophylline is high in efficiency and low in consumption.

Description

technical field [0001] The invention belongs to the technical field of extraction of plant effective components, and in particular relates to a process for extracting rhynchophylline from Uncaria uncaria. Background technique [0002] Natural plants are increasingly favored by people because of their rich resources, less toxic and side effects, no drug resistance, and no harmful residues. The ingredients contained in natural plants are very complex, which can be divided into active ingredients, ineffective ingredients and toxic ingredients. Active ingredients include terpenoids, glycosides, organic acids and trace elements. There are many extraction methods for effective active ingredients of natural plants, and the traditional extraction methods mainly include decoction, dipping, and reflux extraction. The decoction method is convenient and easy, but there are many impurities in the decoction liquid, which is prone to mildew and corruption, and some heat-labile or volatil...

Claims

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Application Information

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IPC IPC(8): C07D471/20
CPCC07D471/20
Inventor 唐翔
Owner 唐翔
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