Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medical application of bavachalcone and analogue thereof

A kind of usage and pharmaceutical technology, applied in the field of medicine, can solve the problem of limited function of repairing damaged endothelium

Inactive Publication Date: 2016-09-28
SHANGHAI UNIV OF T C M
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mature vascular endothelial cells are limited by proliferation and division, and their function of repairing damaged endothelium is limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical application of bavachalcone and analogue thereof
  • Medical application of bavachalcone and analogue thereof
  • Medical application of bavachalcone and analogue thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1. The role of psoralen chalcone in promoting the differentiation of bone marrow stem cells into endothelial progenitor cells in vitro

[0049] 1.1 Purpose: To observe whether psoralen chalcone can promote the differentiation of bone marrow stem cells into endothelial progenitor cells and endothelial cells in the state of cell culture.

[0050] 1.2 Experimental materials:

[0051] 1.2.1 Reagents

[0052] Psoralen chalcone monomer was purchased from Shanghai Yousi Biotechnology Co., Ltd. (No. 566 Yueluo Road, Baoshan District, Shanghai), and its purity was higher than 99.8%; GBM-2 medium was purchased from Lonza Company of the United States; white blood cell separation fluid -1083, Triton-100, and gelatin were purchased from Sigma, USA; antibodies: CD34 (ab185732), vWF (ab6994), anti-rabbit IgG antibody from donkey (ab150073, FITC-labeled fluorescence) were purchased from Abcam, USA; streptomycin and penicillin , American Life Company;

[0053] 1.2.2 Experime...

Embodiment 2

[0087] Example 2. Psoralen chalcone promotes the mobilization of endothelial progenitor cells in the circulating blood of rats

[0088] 2.1 Purpose: To observe whether psoralen chalcone can promote the increase of circulating endothelial progenitor cells in rats.

[0089] 2.2 Experimental materials:

[0090] 2.2.1 Reagents

[0091]Psoralen chalcone monomer was purchased from Shanghai Yousi Biotechnology Co., Ltd. (No. 566 Yueluo Road, Baoshan District, Shanghai), and its purity was higher than 99.8%; GBM-2 medium was purchased from Lonza Company of the United States; white blood cell separation fluid -1083, Triton-100, gelatin, and sodium carboxymethylcellulose (CMC-Na) were purchased from Sigma, USA; antibodies: CD34 (ab187284), CD31 (ab33858) were purchased from Abcam, USA.

[0092] 2.2.2 Experimental animals

[0093] Wistar rats, male, 8 weeks old, healthy. Purchased from Shanghai Xipuer-Bikay Experimental Animal Co., Ltd., animal license number: SYXK (Shanghai) 2013-0...

Embodiment 3

[0108] Example 3. Psoraleachalcone promotes blood flow recovery in ischemic tissue

[0109] 3.1 Purpose: To observe whether psoralen chalcone can promote capillary neogenesis by increasing circulating endothelial progenitor cells, and further improve blood circulation in ischemic limbs.

[0110] 3.2 Experimental materials:

[0111] 3.2.1 Reagents

[0112] Psoralen chalcone monomer was purchased from Shanghai Yousi Biotechnology Co., Ltd. (No. 566, Yueluo Road, Baoshan District, Shanghai), and its purity was higher than 99.8%; sodium carboxymethylcellulose (CMC-Na), purchased from Sigma Company of the United States; penicillin, urethane, sodium pentobarbital, paraformaldehyde, etc. were purchased from Sinopharm.

[0113] 3.2.2 Experimental animals

[0114] Wistar rats, male, 8 weeks old, healthy. Purchased from Shanghai Xipuer-Bikay Experimental Animal Co., Ltd., animal license number: SYXK (Shanghai) 2013-0058. Animal feed The irradiated mouse feed was from Shanghai Shili...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to the field of medicine, in particular to a medical use of psoralenchalcone and its analogues, which are compounds with the structure of formula (I), or their pharmaceutical Acceptable salts, tautomers, stereoisomers or prodrugs above: Among them, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 each independently selected from the group consisting of hydrogen, ORa, OCOORa, OCONRaR b 、OSO 2 Ra and OSO 3 Ra; the Ra and R b each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted C6-C30 aryl group, and substituted or unsubstituted C1-C30 heteroaryl group; the psoralen chalcone and its analogues are used to prepare medicines or health care products for promoting vascular endothelial repair and / or angiogenesis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the medical application of psoraleachalcone and its analogues. Background technique [0002] Vascular endothelial injury is the initiating factor of atherosclerosis, and vascular injury may also lead to extremity ischemia, coronary heart disease and other diseases. Mature vascular endothelial cells are limited by proliferation and division, and their function of repairing damaged endothelium is limited. Recent studies have found that there are endothelial progenitor cells (Endothelial Progenitor Cells, EPCs) in the peripheral blood in vivo, which can differentiate into endothelial cells and further repair damaged blood vessels or participate in angiogenesis. Endothelial progenitor cells are precursor cells that can specifically home to the injured area and directly differentiate and proliferate into vascular endothelial cells (ECs). After birth, EPCs participate in angiogenesis and have...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A23L33/10A23L33/105A61P9/12A61P9/10A61P3/10
CPCA61K31/12A23V2002/00A23V2200/326A23V2200/328A23V2250/2132
Inventor 许锦文凌霜倪荣镇
Owner SHANGHAI UNIV OF T C M
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com