9 results about "Endothelial repair" patented technology

The application discloses a controllable degradation high-corrosion-resistance medical magnesium-aluminum alloy blood vessel stent and a preparation method thereof. The method comprises the following steps: subjecting magnesium alloy ingots containing Al, Zn, Ca and Mn to homogenization treatment, hot extrusion, cold drawing and recrystallization annealing to obtain low-aluminum magnesium-aluminum alloy microtubular materials containing aluminum second-phase non-continuous discrete distribution; after laser cutting, deburring, electrochemical polishing and surface activation, an inner layer rich in MgF2 and an outer layer rich in calcium and phosphorus are sequentially constructed; a polydopamine interface anchoring layer is formed, and a degradable polymer sealing liquid containing a heparinized hyaluronic acid-REDV peptide composite active component is coated to form an active flexible sealing layer after solidification. The stent obtained by the application has good corrosion resistance, controllable degradation, mechanical support retention capacity and endothelial repair promotion performance.

The invention discloses an application of a traditional Chinese medicine composition in preparation of drugs for treating cardiovascular and cerebrovascular diseases in cooperation with blood pricking therapy, and relates to the technical field of traditional Chinese medicine, the traditional Chinese medicine composition comprises a Xuesaitong injection, a ginkgo dipyridamole injection, a salvia miltiorrhiza injection, an astragalus membranaceus injection, a Xiaoyao pill oral preparation and a pulse-activating decoction oral liquid; according to the application of the traditional Chinese medicine composition in preparation of the medicine for treating cardiovascular and cerebrovascular diseases in cooperation with the blood pricking therapy, the traditional Chinese medicine composition has the effects of reducing the weight of thrombus, improving hemorheology and promoting vascular endothelial repair on the basis of the traditional Chinese medicine logic of first dissolving, then clearing and expanding, then removing blood stasis and descending, then purging outwards, then warming and consolidating and finally tonifying internally; the composition is obviously superior to the combination of any two or three injections, and is also superior to the simultaneous administration group of four injections; sequential administration is combined with blood pricking to form a closed loop of'drug internal dissolution-external diarrhea-rerepair ', blood pricking is carried out after the salvia miltiorrhiza injection is infused, the defect that the effect is limited when traditional Chinese medicine is independently applied is overcome, and the scheme is easy to popularize.

The embodiment of the invention relates to the technical field of medical coating materials, in particular to a method for forming an active coating on the surface of a degradable plugging device and the degradable plugging device, and the method comprises the following steps: preparing a perfluorohexane liposome loaded with stromal cell-derived factor-1 alpha (SDF-1 alpha); preparing nano particles of the polylactic acid-glycolic acid copolymer, the rapamycin and the nitric oxide donor; preparing a methacryloyl gelatin-tannic acid hydrogel carrier; mixing the liposome and the nanoparticles into the hydrogel carrier; and soaking the degradable plugging device in the mixture obtained in the previous step, and carrying out photo-crosslinking treatment on the mixture, so that an active coating is formed on the surface of the degradable plugging device. Therefore, comprehensive consideration of'implantation early endothelial repair-implantation later cardiac muscle tissue remodeling 'is realized, controllable sequential repair of the degradable plugging device on the heart defect part is ensured, and the endogenous function repair effect of the heart of a patient is improved.

The invention discloses a magnetic induction power generation intravascular stent, a treatment system and a control method thereof, and relates to the technical field of vascular intervention medical instruments. The system comprises a stent serving as an implantation unit and an in-vitro unit, the stent body is of a tubular woven structure, and a closed loop composed of conductive fibers is integrated in the stent body and used for cutting magnetic induction lines for power generation. The in-vitro unit comprises a magnetic field generating device for generating a rotating magnetic field, a driving device and a processing unit. The invention further provides a control method of the system, and the output current of the support is dynamically controlled by adjusting magnetic field parameters. Energy is transmitted through wireless magnetic induction, so that the stent generates controllable electrical stimulation on local blood vessels on the premise that a built-in battery is not needed, the problems that an existing electrified stent is short in power supply service life, uncontrollable in parameter and high in biological safety risk are effectively solved, vascular endothelial repair can be accurately promoted, abnormal proliferation of smooth muscle cells is inhibited, and the vascular endothelial repair rate is increased. The problem of restenosis in the stent is effectively prevented and treated.

The invention discloses a piezoelectric composite intravascular stent and a preparation method and application thereof, and belongs to the technical field of biomedical materials and medical instruments.The piezoelectric composite intravascular stent comprises a stent body, and the stent body is of a tubular structure formed by weaving piezoelectric composite fibers; the piezoelectric composite fiber comprises a substrate material and a piezoelectric enhancement component, the substrate material comprises a fluorine polymer piezoelectric material, the piezoelectric enhancement component is lead-free piezoelectric ceramic nanoparticles, and the lead-free piezoelectric ceramic nanoparticles comprise at least one of barium titanate, potassium niobate and zinc oxide. The mass ratio of the lead-free piezoelectric ceramic nanoparticles in the piezoelectric composite fiber is 1%-10%; the stent body can generate output voltage of 50mV-100mV under the action of blood flow shearing force, and is used for promoting vascular endothelial repair and inhibiting proliferation and migration of vascular smooth muscle cells. The problems that a traditional intravascular stent cannot regulate and control the vascular repair process through electrical stimulation, application of existing piezoelectric materials cannot meet the characteristic requirements of the intravascular stent, and then postoperative intravascular restenosis is difficult to prevent and treat can be solved.

The invention belongs to the technical field of biological medicine, and particularly relates to a noninvasive controllable flexible biological electronic patch for treating diabetic erectile dysfunction. The erectile dysfunction related to diabetes is difficult to recover due to long-term damage of a cavernous body microenvironment, traditional oral administration or cavernous body injection treatment has poor targeting, non-uniform distribution and complication risk, and long-term curative effect is difficult to realize. The invention provides a flexible and attachable bioelectronic patch which is used for noninvasively, painlessly and controllably adjusting an erectile tissue microenvironment. The device synergistically promotes local vascular active factor expression and endothelial repair through mild electrical stimulation, realizes uniform transdermal delivery of drug molecules, shows high delivery efficiency and cell activity, and significantly improves cavernous body blood flow and cell functions. In an in-vitro cell model and a diabetic animal model, the device shows better vascular regeneration and function recovery effects than traditional medicine or injection therapy.

This invention relates to the field of biomimetic nanozymes and their preparation technology, disclosing a biomimetic nanozyme, its preparation method, and its applications. A peptide-functionalized biomimetic nanozyme (HRPL) is obtained by loading rapamycin onto HMPB nanozymes, coating the surface with a platelet membrane, and functionalizing it with the integrin-binding peptide LXW7. The binding of the platelet membrane to the LXW7 peptide enables targeted delivery to the site of endothelial injury, promoting endothelial repair and re-epithelialization. In an acidic inflammatory microenvironment, HRPL releases rapamycin, inhibiting smooth muscle cell proliferation and migration, and preventing restenosis. HRPL also scavenges reactive oxygen species, reducing oxidative stress and local inflammation, thereby improving the vascular microenvironment. The therapeutic effect was evaluated using a typical rat carotid balloon injury model. This dual-targeting mechanism not only promotes endothelial repair but also reduces restenosis and inflammation, showing significant clinical therapeutic potential. Especially after stent implantation, HRPL helps improve prognosis, reduce complications, and restore vascular homeostasis.

The invention aims to apply cryptochlorogenic acid as a raw material to senescence, migration and tubulation of vascular endothelial cells based on vascular injury pathology, and is used for treating Alzheimer's disease. The Alzheimer disease medicine containing cryptochlorogenic acid is prepared based on vascular endothelial repair, the active ingredient in the medicine is cryptochlorogenic acid, and the medicine is used for inhibiting senescence of vascular endothelial cells, recovering migration ability of the vascular endothelial cells and recovering tubulation ability of the vascular endothelial cells; inhibiting hippocampus CA1 cell atrophy of the animal model with Alzheimer's disease; the damage of Alzheimer's disease serum to a vascular endothelial cell barrier is inhibited.

The present invention discloses a preparation method and application of a responsive anticoagulant hydrogel material that releases NO, comprising: providing methacryloyl-recombinant collagen; providing methacryloyl-recombinant hyaluronic acid; providing caffeic acid arginine amide-modified hyaluronic acid; and obtaining a responsive anticoagulant hydrogel material that releases NO using methacryloyl-recombinant collagen, methacryloyl-recombinant hyaluronic acid, and caffeic acid arginine amide-modified hyaluronic acid as raw materials. The prepared hydrogel material has the advantages of antibacterial, promoting endothelial cell proliferation, inhibiting smooth muscle cell proliferation, anti-inflammatory, promoting angiogenesis, and inhibiting thrombosis. Arginine can act as an endogenous NO donor in the blood to release NO molecules, thereby promoting vascular endothelial repair. The introduced NO molecules give the hydrogel material good anticoagulant properties, and is expected to be used in the preparation of artificial vascular anticoagulant coatings.