30 results about "Endothelial repair" patented technology

The invention relates to an application of amlexanox or salt thereof or a solvate thereof in preparing medicines having a smooth muscle cell inhibiting effect, in particular to an application in medicines for preventing and treating vascular restenosis. The invention also relates to the technical field of medical apparatuses. The amlexanox or the salt or the pharmaceutical composition thereof is distributed on the surface of the medical apparatus, in particular a drug stent. A completely new bio-activity of the amlexanox is discovered, exactly the amlexanox is high in activity of inhibiting smooth muscle cell proliferation; in comparison with currently common smooth muscle cell proliferation inhibitors, the amlexanox also has the characteristic of being low in performance of inhibiting endothelial cell growth; therefore, the amlexanox is especially applicable to medical apparatuses; and the amlexanox can prevent the vascular restenosis occurrence rate, and in addition, the amlexanox can prevent delay of endothelial repair; therefore, the time of taking anti-thrombus and antiplatelet medicines of a patient after an operation can be shortened, and a long-term curative effect can be greatly improved.

The invention belongs to the technical field of genetic engineering, and in particular relates to a fusion protein for promoting endothelial repair and its preparation method and application. The amino acid sequence of the fusion protein promoting endothelial repair of the present invention is shown in SEQ ID NO.1. The fusion protein for promoting endothelial repair provided by the present invention can efficiently and specifically promote the adhesion of endothelial cells and endothelial progenitor cells, can promote the proliferation of endothelial cells, and will not increase the adhesion of smooth muscle cells and endothelial inflammation, and is beneficial to endothelial cells. Cellular tight junctions and NO release, thereby accelerating endothelialization of blood vessels. The fusion protein or its prepared recombinant carrier can be used in the preparation of biomaterials promoting endothelial repair, and has important clinical significance.

The invention relates to a preparation method of blood contact material for improving the biocompatibility and a blood contact material, and relates to the field of biomedical functional materials. The preparation method of the blood contact material for improving the biocompatibility is that the MES, the EDC, the NHS and the water are uniformly mixed and prepared into an activating agent; the base material with the amino-rich coating is immersed in the first mixed solution prepared by the hyaluronic acid solution and the activating agent to carry out the first amine reaction, then is taken out for cleaning with water for a plurality of times to obtain the HA-modified material; the HA-modified material is immersed in a second mixed solution prepared by the selenocysteamine solution and theactivating agent to carry out the second amine reaction, then is taken out for cleaning with water for multiple times, and the blood contact material is obtained. The preparation method can remarkably improve the biocompatibility of the material, so as to reduce the incidence of adverse reaction; the blood contact material has good anti-coagulation, smooth muscle hyperplasia, and endothelial repair function and biocompatibility.

The invention discloses a construction method of an enzyme-reponsive multifunctional nano-coating. The construction method comprises the following steps: firstly, immobilizing avidin molecules to the surface of dopamine-coated stainless steel; then, on the basis of specific recognition and binding effects between avidin and biotin, immobilizing biotinylated heparin / PEI nanoparticles to the surface of a material, and further binding high-concentration avidin molecules to residual biotin on the surface of a nanoparticle coating, so that a novel biotin binding site is introduced; then, continuing to assemble biotinylated enzyme-responsive polypeptide to the surfaces of the nanoparticles on the basis of an interaction between the biotin and the avidin; and finally, by virtue of an EDC / NHS / MES coupling agent, immobilizing SDF-1[alpha] to an amino terminal of the polypeptide in a covalent mode, so that the multifunctional nano-coating, which has a matrix metalloproteinase 9 responsive characteristic, is constructed. According to the construction method provided by the invention, by constructing a multifunctional layer, which has anti-coagulating and endothelial regeneration inducing capacities, on a titanium surface, blood compatibility and a damaged endothelial repair capacity of the material can be obviously improved.

The present invention relates to the field of therapy and prophylaxis of vascular tissue damage and / or complications and / or disease of vascular tissue by vascular regeneration and endothelium repair. The inventors have found that administration of an androgen receptor agonist alleviates one or more adverse vascular diseases and / or vascular complications thereof or adverse effects of androgen deficiency, with implications for prophylactic and therapeutic interventions.