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Guaifenesin Anhydrous Swallow Taste-Masked Granules

A technology of guaifenesin and taste-masking granules, which can be applied in the fields of ether/alcetal active ingredients, drug combinations, nervous system diseases, etc., and can solve the problems that have not yet been studied and reported on anhydrous swallowing or anhydrous swallowing granules , Affect drug compliance and other issues, to achieve the effect of improving drug compliance and increasing the applicable population

Active Publication Date: 2020-04-14
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The guaifenesin pharmaceutical preparations in the prior art are mainly syrups, granules and tablets. On the one hand, there are bitter and peculiar smells after taking the medicine, which affects the compliance of the medicine after taking the medicine. On the other hand, the existing oral solid preparations of guaifenesin When taking the medicine, it is necessary to drink water to smooth the throat. For some patients who are inconvenient to drink water, the application of the medicine is limited.
[0006] At present, in the prior art oral solid preparations, especially granules, there is no research and report on anhydrous swallowing or anhydrous swallowing of granules

Method used

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  • Guaifenesin Anhydrous Swallow Taste-Masked Granules
  • Guaifenesin Anhydrous Swallow Taste-Masked Granules
  • Guaifenesin Anhydrous Swallow Taste-Masked Granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Guaifenesin Anhydrous Swallowing Taste-Masking Granules

[0034] The composition of the guaifenesin anhydrous swallow taste-masking granule unit preparation is as follows:

[0035] Composition list:

[0036]

[0037] making process:

[0038] The drug-loaded pills are prepared by extrusion and spheronization. The drug-loaded pills are respectively coated with a taste-masking layer and a smooth layer. Each layer is packaged by a fluidized bed, and the coated pellets are mixed with flavoring materials to make a semi-finished product. Concrete preparation process is as follows:

[0039] 1. Preparation of loaded pills:

[0040] The drug-loaded pellets are prepared by extrusion and spheronization.

[0041] 1.1 Preparation of the adhesive: the prescription amount of povidone K25 was prepared into an aqueous solution with a concentration of 15% (w / w) for later use.

[0042] 1.2 Preparation of soft materials: put the prescribed amount of microcrystalline cellu...

Embodiment 2

[0066] Example 2: Guaifenesin Anhydrous Swallowing Taste-Masked Granules

[0067] 1. Prescription composition and preparation process parameters of drug-loaded pills:

[0068]

[0069]

[0070] 2. The preparation and packaging process of the taste-masking layer solution

[0071]

[0072]

[0073] 3. The preparation and packaging process of the smooth layer solution

[0074]

[0075]

[0076] 4. Experiments on the influence of weight gain of each layer on release rate:

[0077] (1) Test on the influence of the increase in the weight of the taste-masking layer on the release rate: the results are as follows in Table 3-4 and figure 2

[0078] 1.1 Release in water: See Table 3 for the results.

[0079] Table 3 Release degree in water

[0080]

[0081] The results show that the sample with a weight gain of 7.3% in the taste-masking layer, the release rate in water exceeds the limit requirement due to the thin coating film, and the other samples with weigh...

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PUM

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Abstract

The invention provides a gualfenesin water-free deglutible odor masking granule, which is prepared by mixing guaifenesin coated pellets and flavoring materials, wherein the guaifenesin coated pellets are prepared by sequentially coating a specific odor masking layer and a specific smooth layer on medicine carrying pellets. The gualfenesin water-free deglutible odor masking granule has the advantages that on one hand, the bitter taste and the foreign odor of medicine are covered and masked; on the other hand, unexpectedly, a patient can swallow the gualfenesin water-free deglutible odor masking granule without drinking water in the taking process, so that the medicine use compliance is effectively improved; the applicable user groups of the patients are increased; the medicine taking by children is particularly facilitated; test results prove that the granule is coated by the odor masking layer and the smooth layer, but the main medicine of gualfenesin can be fast released and absorbed in the body; the medicine can be fast released after being orally taken into the gastrointestinal system; and the coated odor masking layer and the coated smooth layer cannot influence medicine release or absorption.

Description

technical field [0001] The present invention relates to a guaifenesin pharmaceutical preparation, in particular, it provides a guaifenesin anhydrous swallow taste-masking granule, the patient takes the granule without water to assist smooth swallowing, and adopts anhydrous swallowing method Taking medicine belongs to the field of pharmaceutical preparations. Background technique [0002] Guaifenesin is 3-(2-methoxyphenoxy)propane-1,2-diol, white or off-white crystalline powder, slightly soluble in water and soluble in ethanol. [0003] After oral administration, it stimulates the gastric mucosa, reflexively increases bronchial secretion, and dilutes sputum. It also has antiseptic and antiseptic effects. This product also has antitussive, antispasmodic, and anticonvulsant effects. It is used for chronic bronchitis with phlegm cough, lung abscess, bronchiectasis, and secondary asthma. Often used in combination with other antitussive and antiasthmatic drugs. It is used when ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/09A61K47/36A61P11/10A61P11/00A61P11/14A61P1/06A61P25/08A61P11/06
Inventor 王锦刚蒋海松朱德志朱广辉
Owner COSCI MED TECH CO LTD