Novel pharmaceutical composition of compound amino acid injection 18AA-I and application of pharmaceutical composition

Abstract

The invention provides a novel pharmaceutical composition of a compound amino acid injection (18AA-I). The pharmaceutical composition disclosed by the invention is applicable to the preparation of medicines for patients whose body's metabolic needs for amino acid cannot be satisfied due to insufficient protein intake, absorption obstacle and the like, for improving nutritional status of postoperative patients and for preventing or treating such nervous system diseases as metabolic acidosis, hepatic coma or cerebral trauma, cerebral hypofunction, neurasthenia, minor epilepsy and the like; therefore, the obtained finished product is more adaptive to new people or is well targeted and is better in clinical safety in clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, it is provided for patients whose amino acids cannot meet the metabolic needs of the body, such as insufficient protein intake and malabsorption. A new pharmaceutical composition of compound amino acid injection (18AA-I) which is also used to improve the nutritional status of patients after surgery, as well as its preparation and use. The product of the present invention is more suitable for patients who need to supplement 18AA-I amino acid injection under many diseases or symptoms such as metabolic acidosis or hyperchloremic metabolic acidosis, and the product of the present invention has wider safety in clinical use Or more or updated indications or adapted populations, etc. Background technique [0002] Protein is the main component of cell structure. The basic unit of protein structure is amino acid. The human body needs to take in a certain amount of protein every day to mee...

AI Technical Summary

Problems solved by technology

We found that the injection of the existing compound amino acid injection (18AA-I) in the case of a variety of different diseases, including prone to metabolic acidosis, also has defects or insufficient or unsatisfactory or hidden dangers of varying degrees. In the case of close days or more and more emphasis on individualized treatment, this greatly reduces the safety and convenience or adaptability of medication; when using tyrosine in the preparation of composition solutions, it is relatively difficult to prepare because of its low solubility. Trouble, switching to acetyltyrosine or N-acetyl-L-tyrosine makes it easier to prepare the solution; other salts of this medicine that are different from calcium chloride are beneficial to change the shortcomings of the prior art, including Irritant, etc., provide a new combination of calcium salts, such as calcium glutamate or L-calcium glutamate, or calcium gluconate, or calcium glucoheptonate, or calcium lactate, or calcium acetate, or calcium glycerophosphate, Or calcium fructonate etc., therefore, the present invention provides the new pharmaceutical composition of new novel compound amino acid injection (18AA-I) for clinical, provides the preparation of new pharmaceutical composition, provides new better than existing preparation Pharmaceutical composition preparations not only reduce adverse reactions in different situations, improve clinical treatment effects, provide new options for clinics, and meet clinical needs in different situations

Images