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Compound amino acid injection 18AA-V pharmaceutical composition and application thereof

A 18AA-V, compound amino acid technology, applied in the direction of drug combination, drug delivery, medical preparations containing active ingredients, etc., can solve problems such as adverse problems, unusable diseases, acid-base imbalance, etc.

Inactive Publication Date: 2016-02-10
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compound amino acid injection (18AA-V) as an amino acid drug (National Drug Standard WS 1 -(X-324)-2003Z), used for patients with insufficient protein intake, malabsorption and other amino acids that cannot meet the metabolic needs of the body, and also used to improve the nutritional status of patients after surgery, but the existing preparations may be injected into the body in some cases Lead to acid-base imbalance or other adverse reactions or restrictions on indications, etc., resulting in the inability to use some diseases or unexpected adverse problems after use, or restricting the clinical selectivity of the drug or the drug, making It becomes the focus of or object of study in pharmacy or pharmacology or related disciplines

Method used

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  • Compound amino acid injection 18AA-V pharmaceutical composition and application thereof
  • Compound amino acid injection 18AA-V pharmaceutical composition and application thereof
  • Compound amino acid injection 18AA-V pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0252] Embodiment 1, the preparation of compound amino acid injection (18AA-V), prescription:

[0253] L-arginine 23.90g; L-histidine 18.2g; L-leucine 37.9g; L-isoleucine 17.0g; L-lysine acetate 37.69g; L-phenylalanine 28.3g ;L-Threonine 19.7g; L-Valine 13.6g; L-Methionine 10.6g; L-Tryptophan 3.9g; Glycine 32.4g; L-Alanine 18.8g; L-Proline L-tyrosine 10.0g; L-tyrosine 1.1g; L-serine 6.7g; L-cysteine ​​3.035g; L-aspartic acid 11.5g; L-glutamic acid 19.7g; Xylitol 500.0g; Sodium bisulfite 5.0 grams;

[0254]

[0255] Preparation Process:

[0256]Weigh each raw material and auxiliary material according to the prescription; add 8000ml of water for injection into the dispensing tank, heat to boil, repeatedly vacuumize and replace with nitrogen to reduce the oxygen content in the dispensing tank, and then fill the tank with nitrogen during the whole process. Add raw and auxiliary materials sequentially between 96°C and 85°C: xylitol, antioxidant (sodium bisulfite), L-tyrosine,...

Embodiment 2

[0258] Embodiment 2, the preparation of compound amino acid injection (18AA-V), prescription:

[0259] L-arginine 23.898 grams;

[0260] L-histidine 18.2 grams;

[0261] L-leucine 37.9g;

[0262] L-isoleucine 17.0g;

[0263] L-Lysine acetate 37.7 grams;

[0264] L-phenylalanine 28.3g;

[0265] L-Threonine 19.7g;

[0266] L-valine 13.6g;

[0267] L-methionine 10.6g;

[0268] L-tryptophan 3.9g;

[0269] Glycine 32.4g;

[0270] L-alanine 18.8g;

[0271] L-proline 10.0g;

[0272] L-tyrosine 1.1g;

[0273] L-serine 6.7g;

[0274] L-cysteine ​​3.035 grams;

[0275] L-aspartic acid 11.5g;

[0276] L-glutamic acid 19.7g;

[0277] Xylitol 500.0 grams;

[0278] Edetate calcium sodium 0.5 g (antioxidant);

[0279] 1.5 g tartaric acid (antioxidant)

[0280]

[0281] Preparation Process:

[0282] Weigh each raw material and auxiliary material according to the prescription; add 7500ml of water for injection into the dispensing tank, heat and boil, and repeatedly adopt ...

Embodiment 3

[0284] Embodiment 3, the preparation of compound amino acid injection (18AA-V), prescription:

[0285] L-arginine 25.98g; L-histidine 18.2g; L-leucine 37.9g; L-isoleucine 17.0g; L-lysine acetate 37.7g; L-phenylalanine 28.3g ; L-Threonine 19.7g; L-Valine 13.6g; Methionine 11.5g; L-Tryptophan 3.9g; Glycine 32.4g; L-Alanine 18.8g; L-Proline 11.0 g; L-tyrosine 1.1g; L-serine 6.7g; L-cysteine ​​3.16g; L-aspartic acid 11.5g; L-glutamic acid 19.7g; Sorbitol 500.0g; Edetic acid Calcium sodium 0.5g, citric acid 1g;

[0286]

[0287] Preparation Process:

[0288] Weigh each raw material and auxiliary material according to the prescription; 1), add the prescribed amount of sorbitol into a batching bucket, add 1000ml of water for injection, stir to dissolve, add 0.3 g of activated carbon, stir, heat and boil for 20 minutes, and cool to 65-80°C , nitrogen flow for 20 minutes, stand-by; 2), add 7000ml of water for injection in the concentrated mixing tank, fill nitrogen while heating,...

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Abstract

The invention provides a novel compound amino acid injection (18AA-V) pharmaceutical composition. The pharmaceutical composition has the advantages that the pharmaceutical composition can be used for preparing medicines for treating patients with protein intake insufficiency, malabsorption and the like and with amino acids incapable of meeting organism's metabolism requirements, improving nutritional states of the patients after operations and preventing or treating metabolic acidosis and the like, so that products have new intended populations or are better targeted in clinical application and higher in clinical safety.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, it is provided for patients whose amino acids cannot meet the metabolic needs of the body, such as insufficient protein intake and malabsorption. The pharmaceutical composition of the compound amino acid injection (18AA-V), which is also used to improve the nutritional status of patients after surgery, and its preparation and use. The product of the present invention is more suitable for patients who need to supplement 18AA-V amino acid injection under many diseases or symptoms such as metabolic acidosis or hyperchloremic metabolic acidosis, and the product of the present invention has wider safety in clinical use Or more or updated indications or adapted populations, etc. Background technique [0002] Protein is the main component of cell structure. The basic unit of protein structure is amino acid. The human body needs to take in a certain amount of protein every day to meet th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4172A61K9/08A61P3/02A61P3/12A61K31/198A61K31/405A61K31/401
Inventor 刘力
Owner 刘力
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